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Youngster Hallam Amos return to the Newport Gwent Dragons' starting line-up to face Mogliano at Rodney Parade for their Amlin Cup Challenge match on Sunday.
The Dragons have made 10 changes in all - five in the backs and five in the forwards - to the starting XV on duty for the 33-0 victory away at Mogliano last weekend, their only win from three attempts in Pool 3.
Amos replaces Tom Prydie at full-back and Daniel Evans takes over from Lewis Robling at stand-off.
Tonderai Chavhanga comes in on the wing, while Patrick Leach and Ashley Smith form a new centre pairing.
Props Owen Evans and Dan Way, lock Robert Sidoli and back-row duo Tom Brown and Lewis Evans bolster the pack.
The Welsh region trail pool leaders London Wasps - who beat Bayonne on Thursday in their round-four fixture - by 10 points with a game in hand.
Italian side Mogliano have lost all three of their matches so far, conceding 163 points in the process.
Newport Gwent Dragons: 15 Hallam Amos, 14 Tonderai Chavhanga, 13 Patrick Leach, 12 Ashley Smith, 11 Michael Poole, 10 Daniel Evans, 9 Jonathan Evans; 8 Ieuan Jones, 7 Lewis Evans, 6 Tom Brown, 5 Robert Sidoli, 4 Andrew Coombs, 3 Dan Way, 2 Sam Parry, 1 Owen Evans
Replacements: 16 Hugh Gustafson, 17 Phil Price, 18 Nathan Buck, 19 Adam Jones, 20 Toby Faletau, 21 Wayne Evans, 22 Lewis Robling, 23 Jack Dixon
Mogliano: 15 Vittorio Candiago, 14 Filippo Guarducci, 13 Enrico Ceccato, 12 Tommaso Boni, 11 Ezio Galon, 10 Edoardo Padovani, 9 Enrico Endrizzi; 8 Meyer Swanepoel, 7 Andrea Ceccato, 6 Marco Barbini, 5 Enrico Pavanello, 4 Federico Maso, 3 Massimiliano Ravalle, 2 Ivan Gianesini, 1 A Costa Repetto
Replacements: 16 Nicola Corbanese, 17 Laert Naka, 18 Gianluca Ceneda, 19 Jacopo Bocchi, 20 Amedeo Di Pietro, 21 Alberto Lucchese, 22 Giovanni Benvenuti, 23 Antonio Giabardo
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Read the thoughts and opinions of Stuart Barnes with skysports.com