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Harlequins winger Ugo Monye will make his 200th appearance for the club when they face Connacht at The Stoop in the Heineken Cup.
Having been one of nine Harlequins players named in the England elite playing squads earlier this week, Monye returns on the left wing as one of seven changes to the team that defeated London Welsh last weekend.
Mike Brown has been named at full-back with Matt Hopper and Tom Casson returning to partner in the centres.
Olly Kohn will start in the second row, while Maurie Fa'asavalu joins Nick Easter and captain, Chris Robshaw in the back row.
Named among the replacements, following their involvement against London Welsh, are Charlie Matthews, George Lowe and Tom Guest.
Meanwhile, Connacht head coach Eric Elwood has named three personnel changes to the team that beat Dragons last Saturday.
Having missed out on last weekend's clash, flanker Johnny O'Connor's return from injury has bolstered the back row.
O'Connor has been named at Openside while Eoin McKeon, who this week signed a two year extended contract with the province, moves to number eight, as he replaces the injured George Naoupu.
In the back line, Fetu'u Vainikolo is named at number 11 with Tiernan O'Halloran starting on the right wing.
Matthew Jarvis is to replace Dan Parks at out-half in what will be his third Heineken Cup game. The 22-year-old came off the bench in the back-to-back fixtures against French side Biarritz.
Having returned to training last week following injury, Miah Nikora is named on the bench along with replacement winger James Loxton, who could earn his first Heineken Cup appearance on Saturday afternoon.
Harlequins: 15 Mike Brown, 14 Tom Williams, 13 Matt Hopper, 12 Tom Casson, 11 Ugo Monye, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw (c), 6 Maurie Fa'asavalu, 5 George Robson, 4 Olly Kohn, 3 James Johnston, 2 Joe Gray, 1 Joe Marler.
Replacements: 16 Rob Buchanan, 17 Mark Lambert, 18 Will Collier, 19 Charlie Matthews, 20 Tom Guest, 21 Karl Dickson, 22 Ben Botica, 23 George Lowe.
Connacht: 15 Robbie Henshaw, 14 Tiernan O'Halloran, 13 Eoin Griffin, 12 Dave McSharry, 11 Fetu'u Vainikolo, 10 Matthew Jarvis, 9 Kieran Marmion, 8 Eoin McKeon, 7 Johnny O'Connor, 6 Andrew Browne, 5 Mike McCarthy, 4 Michael Swift, 3 Nathan White (capt), 2 Jason Harris-Wright, 1 Denis Buckley.
Replacements: 16 Ethienne Reynecke, 17 Brett Wilkinson, 18 Ronan Loughney, 19 Mick Kearney, 20 Eoghan Grace, 21 Paul O'Donohoe, 22 Miah Nikora, 23 James Loxton.
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|Saturday 7th December|
|18:00||Northampton vs Leinster|
|15:40||Racing Metro 92 vs Harlequins|
|18:00||Ulster vs Benetton Treviso|
|Sunday 8th December|
|15:00||Toulouse vs Connacht|
|15:00||Leicester vs Montpellier|
|12:45||Munster vs Perpignan|
|13:00||Edinburgh vs Gloucester|
|Friday 13th December|
|20:00||Ospreys vs Castres|
|20:00||Glasgow vs Cardiff Blues|
|Saturday 14th December|
|18:00||Leinster vs Northampton|
|13:35||Toulon vs Exeter|
|15:00||Saracens vs Zebre|
|18:00||Connacht vs Toulouse|
|15:40||Scarlets vs Clermont Auvergne|
|13:35||Benetton Treviso vs Ulster|
|15:40||Perpignan vs Munster|
|Sunday 15th December|
|12:45||Harlequins vs Racing Metro 92|
|15:00||Montpellier vs Leicester|
|15:00||Gloucester vs Edinburgh|
|Saturday 11th January|
|TBC||Ospreys vs Northampton|
|TBC||Castres vs Leinster|
|TBC||Exeter vs Glasgow|
|TBC||Toulon vs Cardiff Blues|
|TBC||Toulouse vs Saracens|
|TBC||Connacht vs Zebre|
|Saturday 7th December|
|Clermont Auvergne 32 - 11 Scarlets|
|Zebre 10 - 39 Saracens|
|Exeter 9 - 14 Toulon|
|Friday 6th December|
|Castres 15 - 9 Ospreys|
|Cardiff Blues 29 - 20 Glasgow|
|Sunday 20th October|
|Clermont Auvergne 23 - 16 Harlequins|
|Glasgow 20 - 16 Exeter|
|Northampton 27 - 16 Ospreys|
|Perpignan 31 - 14 Edinburgh|
|Saturday 19th October|
|Scarlets 26 - 26 Racing Metro 92|
|Munster 26 - 10 Gloucester|
|Leinster 19 - 7 Castres|
|Montpellier 8 - 25 Ulster|
|Cardiff Blues 19 - 15 Toulon|
|Zebre 6 - 33 Connacht|
|Friday 18th October|
|Leicester 34 - 3 Benetton Treviso|
|Saracens 16 - 17 Toulouse|
Read the thoughts and opinions of Stuart Barnes with skysports.com