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Bath have named club captain Stuart Hooper in their side to face Bath in Friday's Aviva Premiership clash.
Hooper will partner Dave Attwood in the second row, with Josh Ovens set to make his first Premiership start of the season on the blindside flank.
Former Army back Semesa Rokoduguni will also appear in the competition for the first time, partnering Matt Banahan in the centres, with Kyle Eastmond returning to the wing.
Michael Claassens and Stephen Donald will also return to renew their half-back partnership.
Harlequins have made seven changes to the starting line-up that beat Bath in the LV=Cup - with New Zealand international Nick Evans returning to action.
Evans, fit again after an ankle problem, will team up with scrum-half Karl Dickson.
Ugo Monye, George Robson and Jordan Turner-Hall are all free to start after being released by England, while Luke Wallace and Tom Guest join Nick Evans in the back-row.
On the bench, Jordan Burns is in line to make his first senior appearance for the club.
Bath: 15 Nick Abendanon, 14 Kyle Eastmond, 13 Semesa Rokoduguni, 12 Matt Banahan, 11 Tom Biggs, 10 Stephen Donald, 9 Michael Claassens, 1 Charlie Beech, 2 Lee Mears, 3 Anthony Perenise, 4 Stuart Hooper (c), 5 Dave Attwood, 6 Josh Ovens, 7 Guy Mercer, 8 Simon Taylor.
Replacements: 16 Brett Sharman, 17 Alan Cotter, 18 Kane Palma-Newport, 19 Dominic Day, 20 Ryan Caldwell, 21 Will Skuse, 22 Mark McMillan, 23 Jack Cuthbert
Harlequins: 15 Tom Williams, 14 Ugo Monye, 13 Matt Hopper, 12 Jordan Turner-Hall, 11 Sam Smith, 10 Nick Evans, 9 Karl Dickson, 1 Mark Lambert, 2 Joe Gray, 3 Will Collier, 4 Olly Kohn, 5 George Robson, 6 Tom Guest, 7 Luke Wallace, 8 Nick Easter (c).
Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Kyle Sinckler, 19 Pete Browne, 20 Joe Trayfoot, 21 Jordan Burns, 22 Rory Clegg, 23 Seb Stegmann
"Having lost out to Harlequins in the LV= Cup last week, this is our chance to learn from the mistakes we made and improve on them at the Rec.
"To test ourselves against the likes of Quins is massive for us, and it's probably the biggest match of our season so far - it's a chance for us to prove we can compete with the best."
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|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com