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Sale will start Danny Cipriani at fly-half for the LV= Cup semi-final clash with Saracens at Welford Road on Sunday.
The stand-off was on the bench for last week's drubbing by Leicester at the same venue, but moves up with Nick MacLeod switching to centre alongside the returning Charlie Ingall.
Andy Powell returns to the base of the scrum while James Gaskell switches to his favoured position at flanker while there are also starting spots for Tommy Taylor and Tom Holmes.
Nick Auterac, Jamie George and Petrus du Plessis make up the Saracens front row while captain Nils Mordt and Ben Spencer are the half-back pairing.
Justin Melck continues his return from injury in the back row while Chris Wyles and Mouritz Botha are also in the side.
Schalk Brits, Matt Stevens, Neil de Kock and Charlie Hodgson are among those named on the replacement's bench.
Saracens have won both league meetings between the two sides while a penalty kick proved to be the difference in Sale's favour in the LV=Cup pool game in Manchester earlier this season.
Sale Sharks: 15 Cameron Shepherd, 14 Tom Brady, 13 Jonny Leota, 12 Nick Macleod, 11 Charlie Ingall, 10 Danny Cipriani, 9 Cillian Willis, 8 Andy Powell, 7 David Seymour, 6 James Gaskell, 5 Tom Holmes, 4 Fraser McKenzie, 3 Henry Thomas, 2 Tommy Taylor, 1 Ross Harrison.
Replacements: 16 Marc Jones, 17 Al Dickinson, 18 Tony Buckley, 19 Andrei Ostrikov, 20 James Doyle, 21 Nathan Fowles, 22 Sam James, 23 Will Addison.
Saracens: 15 Ben Ransom, 14 James Short, 13 Chris Wyles, 12 Adam Powell, 11 Joe Maddock, 10 Nils Mordt, 9 Ben Spencer, 8 Ernst Joubert, 7 Nick Fenton-Wells, 6 Justin Melck, 5 Mouritz Botha, 4 George Kruis, 3 Petrus du Plessis, 2 Jamie George, 1 Nick Auterac.
Replacements: 16 Schalk Brits, 17 Jared Saunders, 18 Matt Stevens, 19 Alistair Hargreaves, 20 Andy Saull, 21 Neil de Kock, 22 Charlie Hodgson, 23 Jack Wilson.
"We have reached this stage in the past and we have not progressed so we want to get into the final as this is a cup we have never won.
"Going into the game it's important that we rely on of some of things that we have done well traditionally as a side. That's a strong defence, winning the territorial battle and taking the points when they are available.
"Sale are a very proud club and you expect them to compete, in every aspect and every phase of the game. It's going to be tough up there, but we are looking forward to it."
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