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Top 14 leaders Toulon host Biarritz this weekend before fourth-placed Castres face the unenviable task of travelling to Clermont.
The weekend's action kicks off when Racing Métro take their six-game winning streak to Montpellier.
Perpignan are knocking on the door of the play-offs zone and will expect to break into the top six with a home victory over flagging Grenoble.
Elsewhere, Toulouse are at home to Bordeaux-Bègles, who came desperately close to upsetting the champions earlier this season while Bayonne visit relegation-threatened Agen.
Stade Français will play their last ever match at Stade Charléty against bottom-of-the-standings Mont-de-Marsan.
Rugby Club Toulonnais v Biarritz Olympique
Stade Felix Mayol, Toulon
Biarritz have not won at Stade Mayol in eight years and with Clermont next on the menu, things are not looking great for the Basques.
Nine points off the play-off berths, Biarritz look to have missed the boat for Heineken Cup qualification and will have to aim for place in Europe's top division via a defence of their Amlin Challenge Cup title, which they won in a dour final against Toulon last year.
The leaders, who impressed in their victory over Toulouse last week, are unlikely to do their visitors any favours either as they look to retain their slender lead over Clermont.
Beyond being without a handful of internationals, versatile ex-Springbok forward Danie Rossouw has arrived in Toulon but is not yet registered to play. Delon Armitage is suspended while Joe Van Niekerk and Juan Martin Fernandez Lobbe are injured.
Biarritz will be without suspended scrum-half Dimitri Yachvili, who can count himself very lucky to have been banned for just one week for stamping.
Stade Toulousain v Union Bordeaux-Bègles
Stade Ernest Wallon, Toulouse
Bordeaux-Bègles were able to breath a sigh of relief as they climbed out of the relegation zone last week but a return is on the cards against a Toulouse side that has been bolstered by the return of a number of players.
Prop Jean-Baptiste Poux, loose forward Grégory Lamboley, fly-half Luke McAlister, wing Yves Donguy and centre Yannick Jauzion all return from injury for the champs. Gary Botha has returned to South Africa to recover from injury though.
This fixture last year saw Toulouse win 56-6 but the champions had to work very hard for a two-point in over UBB earlier this season.
Having lost three of their last four games, victory is vital for Toulouse if they hope to secure a home play-off as automatic semi-final qualification now seems out of their reach.
UBB have rested centre Julien Rey but welcome back Tongan Andrew Mailei.
SU Agen v Aviron Bayonnais
Stade Armandie, Agen
Back in the red zone with five rounds to play, Agen can no longer afford to drop points at home.
Win-less in their last three games, Bayonne have not travelled well this season with their only win away from home coming down the road at Biarritz.
Bayonne are without experienced fly-half Benjamin Boyet and there is some doubt over the fitness of scrum-half Cédric Garcia. Centre Manu Ahotaeiloa is back for the Basques.
Stade Français Paris v Stade Montois
Stade Charléty, Paris
Stade Français lost for the first time in the capital this season against Clermont last week at the Stade de France. This week they return to Stade Charléty for the final time as their last two home games are at the national stadium before the move back to the refurbished Stade Jean-Bouin next season.
In a game between the two worst defences in France and with Stade playing for little more than pride, it should be a high-scoring affair.
USA Perpignan v FC Grenoble
Stade Aimé Giral, Perpignan
Perpignan are one of the in-form sides at the moment while Grenoble have won just once in their last five starts.
USAP are pushing for a place in the play-offs and with one of the best home record in the league, they will expect to win despite missing four internationals (Guirado, Mas, Vahaamahina and Hook).
The Catalan injury list features Farid Sid, Robins Tchale Watchou, Jérémy Castex, Jean-Pierre Pérez and Sofiane Guitoune
The hosts do however welcome back Adrien Planté and Jerome Schuster.
South African number eight Shaun Sowerby returns to the Grenoble starting XV.
ASM Clermont Auvergne v Castres Olympique
Parc des Sports Marcel Michelin, Clermont Ferrand
The big one this weekend goes down at fortress Marcel-Michelin, where the hosts' home record is the best in Europe.
Castres arrive full of confidence though following their wins over Toulon and Montpellier and are gunning for Toulouse, who are just two points ahead of them.
Only the very brave would dare bet against Clermont on home soil even if they are without eight players on international duty: Zirakashvili and Kolelishvili (Georgia), Bardy (Portugal) and well as Domingo, Debaty, Kayser, Parra and Fofana (France). Julien Malzieu is the only injury absentee.
Les Jaunards have closed the gap on Toulon and are now within striking distance of the championship lead.
|Click here for more betting|
|Saturday 22nd March|
|15:00||Bayonne vs Bordeaux-Begles|
|15:00||Clermont Auvergne vs Toulon|
|15:00||Grenoble vs Racing Metro Paris|
|15:00||Oyonnax vs Montpellier|
|15:00||Stade Francais vs Toulouse|
|15:00||Perpignan vs Biarritz|
|15:00||Castres vs Brive|
|Saturday 29th March|
|15:00||Biarritz vs Castres|
|15:00||Bordeaux-Begles vs Perpignan|
|15:00||Brive vs Clermont Auvergne|
|15:00||Montpellier vs Bayonne|
|15:00||Oyonnax vs Grenoble|
|15:00||Stade Francais vs Racing Metro Paris|
|15:00||Toulon vs Toulouse|
|Saturday 12th April|
|15:00||Bayonne vs Stade Francais|
|15:00||Clermont Auvergne vs Castres|
|15:00||Grenoble vs Montpellier|
|15:00||Bordeaux-Begles vs Toulon|
|15:00||Perpignan vs Oyonnax|
|15:00||Racing Metro Paris vs Biarritz|
|15:00||Toulouse vs Brive|
|Saturday 19th April|
|15:00||Biarritz vs Brive|
|15:00||Castres vs Montpellier|
|15:00||Oyonnax vs Toulouse|
|15:00||Stade Francais vs Bordeaux-Begles|
|Sunday 2nd March|
|Biarritz 8 - 11 Bayonne|
|Saturday 1st March|
|Toulouse 37 - 9 Perpignan|
|Brive 31 - 6 Grenoble|
|Racing Metro Paris 25 - 15 Castres|
|Toulon 64 - 10 Oyonnax|
|Bordeaux-Begles 26 - 16 Clermont Auvergne|
|Friday 28th February|
|Montpellier 19 - 10 Stade Francais|
|Sunday 23rd February|
|Bayonne 9 - 15 Toulon|
|Saturday 22nd February|
|Castres 29 - 27 Toulouse|
|Bordeaux-Begles 25 - 9 Racing Metro Paris|
|Grenoble 20 - 22 Biarritz|
|Perpignan 12 - 6 Brive|
|Stade Francais 29 - 26 Oyonnax|
|Clermont Auvergne 42 - 16 Montpellier|
|Saturday 15th February|
|Brive 28 - 12 Stade Francais|
|Biarritz 6 - 16 Toulouse|
|Montpellier 50 - 19 Perpignan|
|Racing Metro Paris 18 - 8 Bayonne|
|Toulon 19 - 13 Castres|
|Friday 14th February|
|Grenoble 16 - 13 Clermont Auvergne|
|Saturday 8th February|
|Bayonne 9 - 6 Brive|
|Castres 17 - 16 Oyonnax|
|Perpignan 19 - 19 Racing Metro Paris|
|Toulon 33 - 20 Biarritz|
|Toulouse 12 - 15 Montpellier|
Read the thoughts and opinions of Stuart Barnes with skysports.com