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Stuart Lancaster hands debuts to Kyle Eastmond and Marland Yarde as England aim to complete the double over Argentina on Saturday at Velez Sarsfield.
Rugby league convert Eastmond takes his place in the starting XV at inside centre, while London Irish winger Yarde gets the nod on the left.
Yarde's inclusion means there is no place in the match-day squad for David Strettle, while Eastmond slots into the vacant centre role left by Billy Twelvetrees who was called into the British and Irish Lions squad earlier in the week.
Head coach Lancaster promotes Eastmond from the bench and insists the Bath back has the necessary credentials to terrorise the opposition defence, as England seek their first series win in Argentina since 1981.
"He has got a strong sense of self belief in his own ability which shines through on the training field and he is a dominant player on the field," Lancaster said.
Coincidentally, Northampton's Stephen Myler, who switched codes in 2006, is set to make his international bow from the bench after being named amongst Lancaster's replacements.
England made an impressive start to the two-match Test series with a record 32-3 win in Salta last weekend, the heaviest defeat the Pumas have suffered at the hands of the tourists.
Meanwhile Argentina coach Santiago Phelan has made five changes in personnel as the hosts look to launch a backlash.
Captain Felipe Contempomi has overcome illness to feature in the Pumas half-backs, where he will be joined by Nicolas Vergallo who replaces Martin Landajo at scrum-half.
Gabriel Ascarate comes into the starting line-up at inside centre as Contempomi switches to fly-half while winger Belisario Agulla is preferred on the right with Matias Orlando reduced to the bench.
Up front, Guillermo Roan will take the number one jersey while Rodrigo Baez starts at blindside flanker as Argentina look to strengthen their pack which lost nine line-outs and four scrums in the first Test.
"We must do what we've practiced this week that we didn't do in Salta, play better in the lineouts and scrums," Argentina hooker Martin Garcia Veiga added.
Argentina: 15 Martin Bustos Moyano, 14 Belisario Agulla, 13 Gonzalo Tiesi, 12 Gabriel Ascarate, 11 Manuel Montero, 10 Felipe Contepomi (capt), 9 Nicolas Vergallo, 8 Tomas Leonardi, 7 Benjamin Macome, 6 Rodrigo Baez, 5 Mariano Galarza, 4 Julio Farias Cabello, 3 Maximiliano Bustos, 2 Martin Garcia Veiga, 1 Guillermo Roan.
Replacements: 16 Mauricio Guidone, 17 Pablo Henn, 18 Francisco Gomez Kodela, 19 Esteban Lozada, 20 Tomas De La Vega, 21 Tomas Cubelli, 22 Benjamin Madero, 23 Matias Orlando.
England: 15 Mike Brown, 14 Jonny May, 13 Jonathan Joseph, 12 Kyle Eastmond, 11 Marland Yarde, 10 Freddie Burns, 9 Lee Dickson, 8 Ben Morgan, 7 Matt Kvesic, 6 Tom Wood (capt), 5 Dave Attwood, 4 Joe Launchbury, 3 David Wilson, 2 Rob Webber, 1 Joe Marler.
Replacements: 16 David Paice, 17 Paul Doran Jones, 18 Henry Thomas, 19 Courtney Lawes, 20 Billy Vunipola, 21 Richard Wigglesworth, 22 Stephen Myler, 23 Ben Foden.
"There's definitely going to be a reaction from Argentina and what laid the foundation for our performance last week was our set-piece.
"You only get to see the talent to shine through if you get your fundamentals right: the physicality, the contact area, the defence and the set-piece.
"We will also have to deal with what I am sure will be a highly motivated Argentina side."
|Saturday 30th November|
|Wales 26 - 30 Australia|
|Barbarians 43 - 19 Fiji|
|Sunday 24th November|
|Ireland 22 - 24 New Zealand|
|Saturday 23rd November|
|France 10 - 19 South Africa|
|Scotland 15 - 21 Australia|
|Italy 14 - 19 Argentina|
|Friday 22nd November|
|Wales 17 - 7 Tonga|
|Sunday 17th November|
|Scotland 0 - 28 South Africa|
|Saturday 16th November|
|Ireland 15 - 32 Australia|
|France 38 - 18 Tonga|
|Wales 40 - 6 Argentina|
|England 22 - 30 New Zealand|
|Italy 37 - 31 Fiji|
|Saturday 9th November|
|France 19 - 26 New Zealand|
|Ireland 40 - 9 Samoa|
|Wales 15 - 24 South Africa|
|Scotland 42 - 17 Japan|
|England 31 - 12 Argentina|
|Italy 20 - 50 Australia|
|Saturday 2nd November|
|England 20 - 13 Australia|
|Japan 6 - 54 New Zealand|
Read the thoughts and opinions of Stuart Barnes with skysports.com