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Northampton Saints will be aiming to consolidate their place at the top of the Aviva Premiership table when they host rock-bottom Worcester at Franklin's Gardens on Saturday.
Dean Ryan's troops face a daunting task as the Saints have won their last nine contests in all-competitions and have not been defeated at home in the Premiership for nearly a year.
Meanwhile, relegation-threatened Warriors are still searching for their first win of the league season having lost their last 22 away games. Another loss would break Rotherham's all-time record of defeats from 2000 to 2004.
Saints have made four changes to their starting XV with Lee Dickson returning from England duty to partner Stephen Myler at half-back, with Kahn Fotuali'i dropping to the bench.
Elsewhere Dom Waldouck and Christian Day have picked up leg injuries which have ruled them out of the contest.
Waldouck is replaced by Tom Stephenson, who has scored two tries in his opening two outings for England U20 in the Six Nations.
Day's absence sees Sam Dickinson move up into the second row, with GJ Van Velze starting at number eight and Teimana Harrison taking Van Velze's place on the bench.
Dean Schofield and Leonardo Senatore return to the Warriors starting line-up.
Schofield comes in at lock while Senatore is named at flanker, as director of rugby Dean Ryan makes just two changes to the side which almost defeated Leicester Tigers last Friday.
"The short-term aim for us is to get this group at its best and see if we can compete because we're desperate to fight the challenge of relegation," said Ryan.
"We did a pretty good job against Northampton for 65 minutes when they came to Sixways earlier this season.
"Since then we've proved that as a group we are able to last longer and hopefully we can make things difficult.
"A lot of people did themselves a lot of credit against Leicester last week so they deserve to roll again.
"Saints have huge resources. They've got academy players that step up to Premiership level when players are away on international duty."
Northampton: 15 Wilson, 14 Pisi, 13 Pisi, 12 Stephenson, 11 Elliott, 10 Myler, 9 Dickson; 1 Waller, 2 Haywood, 3 Ma'afu, 4 Manoa, 5 Dickinson, 6 Clark, 7 Dowson (Capt), 8 van Velze.
Replacements: 16 McMillan, 17 Waller, 18 Denman, 19 Nutley, 20 Harrison, 21 Fotuali'i, 22 Hooley, 23 Auagavaia.
Worcester: 15 Pennell, 14 Drauniniu, 13 Grove, 12 Fatiaki, 11 Lemi, 10 Warwick. 9 Arr; 1 Fainga'anuku, 2 Creevy, 3 Andress, 4 Schofield, 5 Galarza, 6 Senatore, 7 Betty, 8 Thomas (Capt).
Replacements: 16 Brooker, 17 Porter, 18 O'Donnell, 19 Percival, 20 de Carpentier, 21 Hodgson, 22 Mieres, 23 Hammond.
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|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Phil Edwards with skysports.com