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Harlequins head into their clash against Newcastle Falcons on Saturday having suffered just one defeat in their last six home matches in all-competitions.
Their last four matches in the Aviva Premiership have all been won by the home side, so they will be favourites to pick up a win against their opponents at Twickenham Stoop.
The Falcons, meanwhile, have slipped to seven straight defeats in the competition and are 11th in the table but well clear of bottom side Worcester.
Harlequins have made three changes to the starting side which beat London Wasps last weekend.
Tom Casson is named at outside centre, partnering Jordan Turner-Hall while Ben Botica starts at fly-half in place of Nick Evans who picked up a foot injury last week.
In the forwards, the front five remain unchanged, while Luke Wallace starts at openside flanker and Maurie Fa'asavalu switches to the blindside. Number eight Nick Easter captains the side.
The Falcons are looking to bounce back from their 24-6 defeat to Bath at The Rec with Scott Lawson returning at hooker exactly a week after winning his 40th cap for Scotland against England in the Calcutta Cup.
The experienced front-rower, 32, is one of five changes to the side with fellow Scot Mike Blair starting for the first time since the turn of the year.
Blair, the most capped Scotland scrum-half of all time, partners former Quins man Rory Clegg at half-back, while Ryan Shortland gets the nod on the wing in place of Sinoti Sinoti who is sidelined with an ankle injury.
"They are a spritely sort of side and they like to move the ball around and hold onto it for long periods," said head coach Peter Russell.
"We have to try and nullify that by bringing the kind of defensive game we showed down at Bath."
Harlequins: 15 Lindsay-Hague, 14 Smith, 13 Casson, 12 Turner-Hall, 11 Monye, 10 Botica, 9 Dickson; 1 Lambert, 2 Ward, 3 Doran Jones, 4 Kennedy, 5 Matthews, 6 Fa'asavalu, 7 Wallace, 8 Easter.
Replacements: 16 Gray, 17 Marfo, 18 Sinckler, 19 Guest, 20 Trayfoot, 21 Stuart, 22 Grimoldby, 23 Sackey.
Newcastle: 15 Cato, 14 Tait, 13 Tiesi, 12 Helleur, 11 Shortland, 10 Clegg, 9 Blair; 1 Vickers, 2 Lawson, 3 Brookes, 4 MacLeod, 5 McKenzie, 6 Welch (c), 7 Saull, 8 Wilson.
Replacements: 16 McGuigan, 17 Strain, 18 Tomaszczyk, 19 Tomes, 20 Hogg, 21 Fury, 22 Hodgson, 23 Powell.
|Click here for more betting|
|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale Sharks vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Phil Edwards with skysports.com