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London Irish are boosted by the return to fitness of captain Bob Casey and fly-half Shane Geraghty for the visit of Newcastle Falcons to the Madejski Stadium.
Casey missed the season-opening defeat at Harlequins due to a leg injury, but is fit to take his place in the second-row against Newcastle.
Geraghty - who has been rehabilitating a leg injury suffered while training with England back in June - is ready to feature in the starting line-up after being an unused replacement last week.
Casey, Geraghty and Dan Murphy are the three changes to the XV that lost at Twickenham, while Jeremy Staunton switches to inside centre to accommodate Geraghty.
Kieran Roche, Tonga Lea'aetoa and Nils Mordt all drop down to the replacements bench.
Newcastle director of rugby John Fletcher is refusing to get carried away after his side opened up their campaign with victory over Sale.
The Falcons overcame the 2006 champions 33-12 at Kingston Park, but Fletcher insists there are still areas for his side to work on.
He told the club's official website: "I expected a win, I thought we would win and we did win, but that's what the players are paid to do so you won't see us singing and dancing about it.
"Naturally a victory brings confidence, and winning is a habit so it's good to get off to a start like that so early in the season.
"It was a good start, not a perfect one, but to get five points from the game puts us in reasonable spirits going in to this weekend.
"Tactically we played much better, but there are still a lot of areas where we can improve so we're not patting ourselves on the back after one win."
Fletcher has been forced to make three changes - with Toby Flood teaming up with the England squad in France, while Mark Mayerhofler and Andy Buist have been ruled out through injury.
Steve Jones has been handed the task of filling Flood's boots, with Tom Dillon and Andy Perry replacing Mayerhofler and Buist respectively.
Newcastle do welcome John Rudd back on to the wing after he was forced to miss the win over Sale with an ankle injury, while South African No 8 Russell Winter is named on the bench.
London Irish: 15 Delon Armitage, 14 Topsy Ojo, 13 Mark Ireland, 12 Jeremy Staunton, 11 Tomas De Vedia, 10 Shane Geraghty, 9. Paul Hodgson; 1 Dan Murphy, 2 David Paice, 3 Faan Rautenbach, 4 Nick Kennedy, 5 Bob Casey (capt), 6 Declan Danaher, 7 Richard Thorpe, 8 Phil Murphy
Replacements: 16 Casey Dunning, 17 Stuart Mackie, 18 Tonga Lea'aetoa, 19 Kieran Roche, 20 Steffon Armitage, 21 Warren Fury, 22 Nils Mordt
Newcastle: 15 Matthew Burke, 14 Tom May, 13 Tom Dillon, 12 Joe Shaw, 11 John Rudd, 10 Steve Jones, 9 James Grindal, 1 Joe McDonnell, 2 Matt Thompson, 3 Micky Ward, 4 Andy Perry, 5 Mark Sorenson, 6 Geoff Parling, 7 Ben Woods, 8 Phil Dowson (capt)
Replacements: 16 Andy Long, 17 David Wilson, 18 Russell Winter, 19 Brent Wilson, 20 Lee Dickson, 21 Adam Dehaty, 22 Ollie Phillips
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|Friday 20th December|
|20:00||Sale Sharks vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:00||Saracens vs Leicester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|15:00||Leicester vs Bath|
|Sunday 5th January|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Bath vs Newcastle|
|15:00||Exeter vs Northampton|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|15:00||Leicester vs Gloucester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
|Sunday 27th October|
|Newcastle 13 - 11 London Irish|
|Wasps 22 - 12 Leicester|
|Saturday 26th October|
|Northampton 41 - 20 Saracens|
|Exeter 40 - 6 Worcester|
|Harlequins 24 - 3 Sale Sharks|
|Friday 25th October|
|Bath 15 - 13 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com