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Exiles v Newcastle: Teams
Player to watch: Steve Jones - The former Border Reivers player only arrived at Kingston Park in the summer but has found himself handed the job of filling in at No 10 in the absence of Jonny Wilkinson and Toby Flood. After only 32 points in 21 appearances for the Scottish side, the pressure will be on Jones to deliver.
Match fact: The Exiles have won six out of their past seven games at the Madjeski Stadium, while the Falcons have not tasted victory on the road since beating Sale on November 17, 2006.
Betting: For the latest Guinness Premiership odds, click here.
At the Madejski Stadium, Sunday September 23, KO 3pm
London Irish are boosted by the return to fitness of captain Bob Casey and fly-half Shane Geraghty for the visit of Newcastle Falcons to the Madejski Stadium.
Casey missed the season-opening defeat at Harlequins due to a leg injury, but is fit to take his place in the second-row against Newcastle.
Geraghty - who has been rehabilitating a leg injury suffered while training with England back in June - is ready to feature in the starting line-up after being an unused replacement last week.
Casey, Geraghty and Dan Murphy are the three changes to the XV that lost at Twickenham, while Jeremy Staunton switches to inside centre to accommodate Geraghty.
Kieran Roche, Tonga Lea'aetoa and Nils Mordt all drop down to the replacements bench.
Falcons flying high
Newcastle director of rugby John Fletcher is refusing to get carried away after his side opened up their campaign with victory over Sale.
The Falcons overcame the 2006 champions 33-12 at Kingston Park, but Fletcher insists there are still areas for his side to work on.
He told the club's official website: "I expected a win, I thought we would win and we did win, but that's what the players are paid to do so you won't see us singing and dancing about it.
"Naturally a victory brings confidence, and winning is a habit so it's good to get off to a start like that so early in the season.
"It was a good start, not a perfect one, but to get five points from the game puts us in reasonable spirits going in to this weekend.
"Tactically we played much better, but there are still a lot of areas where we can improve so we're not patting ourselves on the back after one win."
Fletcher has been forced to make three changes - with Toby Flood teaming up with the England squad in France, while Mark Mayerhofler and Andy Buist have been ruled out through injury.
Steve Jones has been handed the task of filling Flood's boots, with Tom Dillon and Andy Perry replacing Mayerhofler and Buist respectively.
Newcastle do welcome John Rudd back on to the wing after he was forced to miss the win over Sale with an ankle injury, while South African No 8 Russell Winter is named on the bench.
London Irish: 15 Delon Armitage, 14 Topsy Ojo, 13 Mark Ireland, 12 Jeremy Staunton, 11 Tomas De Vedia, 10 Shane Geraghty, 9. Paul Hodgson; 1 Dan Murphy, 2 David Paice, 3 Faan Rautenbach, 4 Nick Kennedy, 5 Bob Casey (capt), 6 Declan Danaher, 7 Richard Thorpe, 8 Phil Murphy
Replacements: 16 Casey Dunning, 17 Stuart Mackie, 18 Tonga Lea'aetoa, 19 Kieran Roche, 20 Steffon Armitage, 21 Warren Fury, 22 Nils Mordt
Newcastle: 15 Matthew Burke, 14 Tom May, 13 Tom Dillon, 12 Joe Shaw, 11 John Rudd, 10 Steve Jones, 9 James Grindal, 1 Joe McDonnell, 2 Matt Thompson, 3 Micky Ward, 4 Andy Perry, 5 Mark Sorenson, 6 Geoff Parling, 7 Ben Woods, 8 Phil Dowson (capt)
Replacements: 16 Andy Long, 17 David Wilson, 18 Russell Winter, 19 Brent Wilson, 20 Lee Dickson, 21 Adam Dehaty, 22 Ollie Phillips
|Click here for more betting|
|Friday 28th November|
|19:45||Bath vs Harlequins|
|Saturday 29th November|
|15:00||Leicester Tigers vs Wasps|
|16:30||Exeter vs Saracens|
|Sunday 30th November|
|13:00||London Irish vs Gloucester|
|14:30||London Welsh vs Northampton|
|15:15||Newcastle Falcons vs Sale Sharks|
|Saturday 20th December|
|14:00||Sale vs Exeter|
|15:00||Gloucester vs Bath|
|15:00||Saracens vs London Welsh|
|15:00||Harlequins vs Newcastle|
|15:00||Northampton vs Leicester|
|Sunday 21st December|
|14:00||Wasps vs London Irish|
|Friday 26th December|
|15:00||London Irish vs London Welsh|
|Saturday 27th December|
|14:00||Sale vs Leicester|
|15:00||Bath vs Exeter|
|15:00||Newcastle vs Saracens|
|15:00||Gloucester vs Wasps|
|15:00||Harlequins vs Northampton|
|Saturday 3rd January|
|15:00||Exeter vs Gloucester|
|15:00||Saracens vs London Irish|
|15:00||Leicester vs Bath|
|15:00||Northampton vs Newcastle|
|Sunday 4th January|
|14:00||Wasps vs Sale|
|14:30||London Welsh vs Harlequins|
|Saturday 10th January|
|14:00||Sale vs Northampton|
|Sunday 23rd November|
|London Welsh 5 - 26 Leicester Tigers|
|Saracens 24 - 31 Northampton|
|Saturday 22nd November|
|London Irish 23 - 33 Bath|
|Exeter 31 - 15 Wasps|
|Friday 21st November|
|Newcastle Falcons 20 - 10 Gloucester|
|Harlequins 12 - 16 Sale Sharks|
|Sunday 16th November|
|Wasps 71 - 7 London Welsh|
|Leicester Tigers 21 - 21 Saracens|
|Saturday 15th November|
|Bath 23 - 14 Newcastle Falcons|
|Sale Sharks 36 - 8 London Irish|
|Friday 14th November|
|Gloucester 15 - 22 Harlequins|
|Northampton 18 - 24 Exeter|
|Sunday 12th October|
|Wasps 29 - 22 Bath|
|Saturday 11th October|
|Northampton 43 - 10 Sale Sharks|
|Saracens 28 - 21 Gloucester|
|Exeter 44 - 24 London Irish|
|London Welsh 3 - 23 Newcastle|
|Friday 10th October|
|Leicester 22 - 16 Harlequins|
Read the thoughts and opinions of Phil Edwards with skysports.com