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Exiles v Newcastle: Teams
Player to watch: Steve Jones - The former Border Reivers player only arrived at Kingston Park in the summer but has found himself handed the job of filling in at No 10 in the absence of Jonny Wilkinson and Toby Flood. After only 32 points in 21 appearances for the Scottish side, the pressure will be on Jones to deliver.
Match fact: The Exiles have won six out of their past seven games at the Madjeski Stadium, while the Falcons have not tasted victory on the road since beating Sale on November 17, 2006.
Betting: For the latest Guinness Premiership odds, click here.
At the Madejski Stadium, Sunday September 23, KO 3pm
London Irish are boosted by the return to fitness of captain Bob Casey and fly-half Shane Geraghty for the visit of Newcastle Falcons to the Madejski Stadium.
Casey missed the season-opening defeat at Harlequins due to a leg injury, but is fit to take his place in the second-row against Newcastle.
Geraghty - who has been rehabilitating a leg injury suffered while training with England back in June - is ready to feature in the starting line-up after being an unused replacement last week.
Casey, Geraghty and Dan Murphy are the three changes to the XV that lost at Twickenham, while Jeremy Staunton switches to inside centre to accommodate Geraghty.
Kieran Roche, Tonga Lea'aetoa and Nils Mordt all drop down to the replacements bench.
Falcons flying high
Newcastle director of rugby John Fletcher is refusing to get carried away after his side opened up their campaign with victory over Sale.
The Falcons overcame the 2006 champions 33-12 at Kingston Park, but Fletcher insists there are still areas for his side to work on.
He told the club's official website: "I expected a win, I thought we would win and we did win, but that's what the players are paid to do so you won't see us singing and dancing about it.
"Naturally a victory brings confidence, and winning is a habit so it's good to get off to a start like that so early in the season.
"It was a good start, not a perfect one, but to get five points from the game puts us in reasonable spirits going in to this weekend.
"Tactically we played much better, but there are still a lot of areas where we can improve so we're not patting ourselves on the back after one win."
Fletcher has been forced to make three changes - with Toby Flood teaming up with the England squad in France, while Mark Mayerhofler and Andy Buist have been ruled out through injury.
Steve Jones has been handed the task of filling Flood's boots, with Tom Dillon and Andy Perry replacing Mayerhofler and Buist respectively.
Newcastle do welcome John Rudd back on to the wing after he was forced to miss the win over Sale with an ankle injury, while South African No 8 Russell Winter is named on the bench.
London Irish: 15 Delon Armitage, 14 Topsy Ojo, 13 Mark Ireland, 12 Jeremy Staunton, 11 Tomas De Vedia, 10 Shane Geraghty, 9. Paul Hodgson; 1 Dan Murphy, 2 David Paice, 3 Faan Rautenbach, 4 Nick Kennedy, 5 Bob Casey (capt), 6 Declan Danaher, 7 Richard Thorpe, 8 Phil Murphy
Replacements: 16 Casey Dunning, 17 Stuart Mackie, 18 Tonga Lea'aetoa, 19 Kieran Roche, 20 Steffon Armitage, 21 Warren Fury, 22 Nils Mordt
Newcastle: 15 Matthew Burke, 14 Tom May, 13 Tom Dillon, 12 Joe Shaw, 11 John Rudd, 10 Steve Jones, 9 James Grindal, 1 Joe McDonnell, 2 Matt Thompson, 3 Micky Ward, 4 Andy Perry, 5 Mark Sorenson, 6 Geoff Parling, 7 Ben Woods, 8 Phil Dowson (capt)
Replacements: 16 Andy Long, 17 David Wilson, 18 Russell Winter, 19 Brent Wilson, 20 Lee Dickson, 21 Adam Dehaty, 22 Ollie Phillips
|Click here for more betting|
|Friday 27th March|
|19:45||Northampton vs Wasps|
|Saturday 28th March|
|15:00||London Irish vs Newcastle Falcons|
|15:00||Leicester Tigers vs Exeter|
|15:15||Saracens vs Harlequins|
|Sunday 29th March|
|14:00||Sale Sharks vs Gloucester|
|14:30||London Welsh vs Bath|
|Friday 10th April|
|19:45||Newcastle vs Bath|
|Saturday 11th April|
|15:00||Harlequins vs Gloucester|
|15:15||Saracens vs Leicester|
|Sunday 12th April|
|14:00||Exeter vs Northampton|
|14:30||London Welsh vs Wasps|
|15:00||London Irish vs Sale|
|Friday 24th April|
|19:45||Bath vs London Irish|
|Saturday 25th April|
|14:00||Sale vs Harlequins|
|15:00||Gloucester vs Newcastle|
|15:00||Leicester vs London Welsh|
|15:15||Northampton vs Saracens|
|Sunday 26th April|
|14:00||Wasps vs Exeter|
|Friday 8th May|
|19:45||Harlequins vs Bath|
|Saturday 9th May|
|14:00||Sale vs Newcastle|
|15:00||Northampton vs London Welsh|
|15:00||Gloucester vs London Irish|
|15:15||Wasps vs Leicester Tigers|
|Sunday 10th May|
|14:00||Saracens vs Exeter|
|Saturday 16th May|
|15:30||Exeter vs Sale|
|Sunday 8th March|
|Newcastle Falcons 12 - 16 Leicester Tigers|
|Wasps 17 - 26 Saracens|
|Saturday 7th March|
|Gloucester 33 - 33 Northampton|
|Exeter 74 - 19 London Welsh|
|Harlequins 26 - 20 London Irish|
|Friday 6th March|
|Bath 12 - 3 Sale Sharks|
|Sunday 1st March|
|Wasps 32 - 21 Gloucester|
|Saturday 28th February|
|Exeter 16 - 6 Bath|
|Saracens 22 - 17 Newcastle Falcons|
|Leicester Tigers 28 - 8 Sale Sharks|
|London Welsh 12 - 50 London Irish|
|Friday 27th February|
|Northampton 17 - 13 Harlequins|
|Sunday 22nd February|
|London Irish 6 - 12 Leicester Tigers|
|Saturday 21st February|
|Bath 13 - 21 Northampton|
|Harlequins 21 - 32 Exeter|
|Gloucester 48 - 10 London Welsh|
|Sale Sharks 14 - 10 Saracens|
|Friday 20th February|
|Newcastle 23 - 23 Wasps|
|Sunday 15th February|
|Wasps 37 - 6 Harlequins|
|London Welsh 12 - 52 Sale|
|Saracens 34 - 24 Bath|
|Saturday 14th February|
|Exeter 46 - 17 Newcastle|
|Friday 13th February|
|Leicester 18 - 15 Gloucester|
|Northampton 15 - 9 London Irish|
Read the thoughts and opinions of Phil Edwards with skysports.com