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London Irish are boosted by the return to fitness of captain Bob Casey and fly-half Shane Geraghty for the visit of Newcastle Falcons to the Madejski Stadium.
Casey missed the season-opening defeat at Harlequins due to a leg injury, but is fit to take his place in the second-row against Newcastle.
Geraghty - who has been rehabilitating a leg injury suffered while training with England back in June - is ready to feature in the starting line-up after being an unused replacement last week.
Casey, Geraghty and Dan Murphy are the three changes to the XV that lost at Twickenham, while Jeremy Staunton switches to inside centre to accommodate Geraghty.
Kieran Roche, Tonga Lea'aetoa and Nils Mordt all drop down to the replacements bench.
Newcastle director of rugby John Fletcher is refusing to get carried away after his side opened up their campaign with victory over Sale.
The Falcons overcame the 2006 champions 33-12 at Kingston Park, but Fletcher insists there are still areas for his side to work on.
He told the club's official website: "I expected a win, I thought we would win and we did win, but that's what the players are paid to do so you won't see us singing and dancing about it.
"Naturally a victory brings confidence, and winning is a habit so it's good to get off to a start like that so early in the season.
"It was a good start, not a perfect one, but to get five points from the game puts us in reasonable spirits going in to this weekend.
"Tactically we played much better, but there are still a lot of areas where we can improve so we're not patting ourselves on the back after one win."
Fletcher has been forced to make three changes - with Toby Flood teaming up with the England squad in France, while Mark Mayerhofler and Andy Buist have been ruled out through injury.
Steve Jones has been handed the task of filling Flood's boots, with Tom Dillon and Andy Perry replacing Mayerhofler and Buist respectively.
Newcastle do welcome John Rudd back on to the wing after he was forced to miss the win over Sale with an ankle injury, while South African No 8 Russell Winter is named on the bench.
London Irish: 15 Delon Armitage, 14 Topsy Ojo, 13 Mark Ireland, 12 Jeremy Staunton, 11 Tomas De Vedia, 10 Shane Geraghty, 9. Paul Hodgson; 1 Dan Murphy, 2 David Paice, 3 Faan Rautenbach, 4 Nick Kennedy, 5 Bob Casey (capt), 6 Declan Danaher, 7 Richard Thorpe, 8 Phil Murphy
Replacements: 16 Casey Dunning, 17 Stuart Mackie, 18 Tonga Lea'aetoa, 19 Kieran Roche, 20 Steffon Armitage, 21 Warren Fury, 22 Nils Mordt
Newcastle: 15 Matthew Burke, 14 Tom May, 13 Tom Dillon, 12 Joe Shaw, 11 John Rudd, 10 Steve Jones, 9 James Grindal, 1 Joe McDonnell, 2 Matt Thompson, 3 Micky Ward, 4 Andy Perry, 5 Mark Sorenson, 6 Geoff Parling, 7 Ben Woods, 8 Phil Dowson (capt)
Replacements: 16 Andy Long, 17 David Wilson, 18 Russell Winter, 19 Brent Wilson, 20 Lee Dickson, 21 Adam Dehaty, 22 Ollie Phillips
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|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Saracens vs Worcester|
|15:00||Exeter vs Harlequins|
|15:00||Gloucester vs London Irish|
|15:00||Sale vs Leicester|
|15:00||Wasps vs Newcastle|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Leicester vs Saracens|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
Read the thoughts and opinions of Stuart Barnes with skysports.com