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Cardiff Blues will go into their final pool game knowing victory against Calvisano will see them qualify as top seeds in the last eight.
After their brilliant victory against Gloucester, Dai Young has made one change with Ben Blair coming in for Tom James - who was sent off early on in last week's match against Gloucester.
Blair, the Blues leading run scorer returns to the side after recovering from a broken thumb. He is restored at full back with Leigh Halfpenny moving to the wing in place of Jones.
Cardiff are the only unbeaten side in the competition with five wins from five, whereas their oppositions Calvisano have yet to accrue a win or a point.
But Young is expecting the Italians to come out all guns blazing. He said: "I know they would love to come and spoil the party.
"Our attitude is to win first and then start thinking about bonus points. There is still work to be done.
"We know from last season that when you get the chance of a home draw you have to nail it.
"Two missed opportunities to score tries against Bristol last year really hurt us and made the difference between playing Toulouse in France or Cardiff.
"I am not saying we would have beaten Toulouse at home, but we would have had a better chance. Now we have to use the Toulouse game as an experience as we move into another quarter-final."
Despite their position in the pool, the Italians will be fielding a strong team.
Welsh prop Ben Evans is set to feature with Italian hooker Leonardo Ghiraldini and number eight Alessandro Zanni.
Meanwhile, in the backs New Zealander Gerard John Fraser will start ahead of Luke McClean, who joins Paul Griffen among the substitutes.
Cardiff Blues: 15 Ben Blair, 14 Leigh Halfpenny, 13 Tom Shanklin, 12 Jamie Roberts, 11 Gareth Thomas, 10 Nicky Robinson, 9 Jason Spice, 8 Andy Powell, 7 Martyn Williams (c), 6 Maama Molitika, 5 Scott Morgan, 4 Deiniol Jones, 3 Gary Powell, 2 Gareth Williams, 1 Gethin Jenkins.
Replacements: 16 Taufa'ao Filise, 17 T Rhys Thomas, 18 Bradley Davies, 19 Xavier Rush, 20 Darren Allinson, 21 Ceri Sweeney, 22 Jamie Robinson.
Calvisano: 15 Ben Smith, 14 Ludovico Nitoglia, 13 Matteo Pratichetti, 12 Garcia Gonzalo, 11 Daniele Forcucci, 10 Gerard John Fraser, 9 Pino Patelli, 8 Alessandro Zanni, 7 Aaron Persico, 6 Filippo Cristiano, 5 Cameron Treloar, 4 Peter Sidoli, 3 Ben Evans, 2 Leonardo Ghiraldini, 1 Alistair McKenzie.
Replacements: 16 Gabriel Bocca, 17 Alejandro Moreno, 18 Luca Beccaris, 19 Matteo Galluppi, 20 Paul Griffen, 21 Nanni Raineri, 22 Luke McLean.
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|Friday 6th December|
|20:00||Castres vs Ospreys|
|20:00||Cardiff Blues vs Glasgow|
|Saturday 7th December|
|18:00||Northampton vs Leinster|
|13:35||Exeter vs Toulon|
|13:35||Zebre vs Saracens|
|13:35||Clermont Auvergne vs Scarlets|
|15:40||Racing Metro 92 vs Harlequins|
|18:00||Ulster vs Benetton Treviso|
|Sunday 8th December|
|15:00||Toulouse vs Connacht|
|15:00||Leicester vs Montpellier|
|12:45||Munster vs Perpignan|
|13:00||Edinburgh vs Gloucester|
|Friday 13th December|
|20:00||Ospreys vs Castres|
|20:00||Glasgow vs Cardiff Blues|
|Saturday 14th December|
|18:00||Leinster vs Northampton|
|13:35||Toulon vs Exeter|
|15:00||Saracens vs Zebre|
|18:00||Connacht vs Toulouse|
|15:40||Scarlets vs Clermont Auvergne|
|13:35||Benetton Treviso vs Ulster|
|15:40||Perpignan vs Munster|
|Sunday 15th December|
|12:45||Harlequins vs Racing Metro 92|
|15:00||Montpellier vs Leicester|
|15:00||Gloucester vs Edinburgh|
|Saturday 11th January|
|TBC||Ospreys vs Northampton|
|Sunday 20th October|
|Clermont Auvergne 23 - 16 Harlequins|
|Glasgow 20 - 16 Exeter|
|Northampton 27 - 16 Ospreys|
|Perpignan 31 - 14 Edinburgh|
|Saturday 19th October|
|Scarlets 26 - 26 Racing Metro 92|
|Munster 26 - 10 Gloucester|
|Leinster 19 - 7 Castres|
|Montpellier 8 - 25 Ulster|
|Cardiff Blues 19 - 15 Toulon|
|Zebre 6 - 33 Connacht|
|Friday 18th October|
|Leicester 34 - 3 Benetton Treviso|
|Saracens 16 - 17 Toulouse|
Read the thoughts and opinions of Stuart Barnes with skysports.com