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Alesana Tuilagi and Louis Deacon return to the Leicester line-up for Sunday's Guinness Premiership trip to Adams Park where they face old rivals Wasps.
Samoan wing Tuilagi is back in action following a knee injury, while England international lock Deacon makes his first senior appearance of the season after overcoming a back problem.
Aaron Mauger captains the team, and George Chuter returns from England duty to claim a place in the front row, with Deacon joining fellow international Ben Kay at lock.
There is a place on the bench for prop Marcos Ayerza after his recovery from an arm injury, and Ben Youngs returns to the squad after playing in England's opening game of the U20 Six Nations Championship last weekend. Ayoola Erinle is also included in the matchday 22 against his former club.
Martin Corry's position among the replacements is subject to the outcome of an independent disciplinary committee hearing in Dublin on Friday.
Making his 17th appearance since joining the club at the start of the season, Serge Betsen will lead a side bolstered by the inclusion of England's Danny Cipriani, Simon Shaw and Tim Payne.
Joining Payne in the front row, Pat Barnard makes his return to action on Sunday after recovering from a neck injury sustained against Newcastle Falcons back in November. In the second row George Skivington, fresh from the England Saxons, joins Shaw, and Dan Leo and John Hart are named alongside captain Betsen in the back row.
Wasps' only defeat in their last four games in the Guinness Premiership came at Sale at the end of December, while Leicester Tigers have not won away from home in the Premiership since a 19-17 victory at Worcester in September.
The Londoners have won the last three encounters between the two clubs since Leicester's 34-24 win in the semi-finals of the EDF Energy Cup at Millennium Stadium, Cardiff, on 22 March 2008.
The Tigers have visited Adams Park on seven previous occasions and have lost only once, on their first ever visit in December 2002.
Wasps: 15 Mark Van Gisbergen, 14 Chris Bishay, 13 Dominic Waldouck, 12 Josh Lewsey, 11 Tom Voyce, 10 Danny Cipriani, 9 Mark Robinson, 8 John Hart, 7 Serge Betsen (c), 6 Dan Leo, 5 George Skivington, 4 Simon Shaw, 3 Pat Barnard, 2 Rob Webber, 1 Tim Payne.
Replacements: 16 Joe Ward, 17 Tom French, 18 Richard Birkett, 19 Hugo Ellis, 20 Joe Simpson, 21 Dave Walder, 22 Rob Hoadley.
Leicester: 15 Scott Hamilton, 14 Matt Smith, 13 Seru Rabeni, 12 Aaron Mauger (c), 11 Alesana Tuilagi, 10 Sam Vesty, 9 Julien Dupuy, 8 Jordan Crane, 7 Ben Woods, 6 Craig Newby, 5 Ben Kay, 4 Louis Deacon, 3 Dan Cole, 2 George Chuter, 1 Boris Stankovich.
Replacements: 16 Mefin Davies, 17 Marcos Ayerza, 18 Martin Corry, 19 Brett Deacon, 20 Ben Youngs, 21 Ayoola Erinle, 22 Johne Murphy.
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|Friday 2nd May|
|19:45||Bath vs Northampton|
|Saturday 3rd May|
|15:00||Saracens vs Worcester|
|15:00||Wasps vs Newcastle|
|15:00||Gloucester vs London Irish|
|15:15||Sale vs Leicester|
|Sunday 4th May|
|14:00||Exeter vs Harlequins|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Leicester vs Saracens|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 20th April|
|Newcastle 18 - 23 Saracens|
|Northampton 36 - 21 London Irish|
|Saturday 19th April|
|Wasps 38 - 30 Gloucester|
|Bath 32 - 20 Worcester|
|Exeter 12 - 55 Sale|
|Friday 18th April|
|Harlequins 24 - 20 Leicester|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
Read the thoughts and opinions of Stuart Barnes with skysports.com