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Alesana Tuilagi and Louis Deacon return to the Leicester line-up for Sunday's Guinness Premiership trip to Adams Park where they face old rivals Wasps.
Samoan wing Tuilagi is back in action following a knee injury, while England international lock Deacon makes his first senior appearance of the season after overcoming a back problem.
Aaron Mauger captains the team, and George Chuter returns from England duty to claim a place in the front row, with Deacon joining fellow international Ben Kay at lock.
There is a place on the bench for prop Marcos Ayerza after his recovery from an arm injury, and Ben Youngs returns to the squad after playing in England's opening game of the U20 Six Nations Championship last weekend. Ayoola Erinle is also included in the matchday 22 against his former club.
Martin Corry's position among the replacements is subject to the outcome of an independent disciplinary committee hearing in Dublin on Friday.
Making his 17th appearance since joining the club at the start of the season, Serge Betsen will lead a side bolstered by the inclusion of England's Danny Cipriani, Simon Shaw and Tim Payne.
Joining Payne in the front row, Pat Barnard makes his return to action on Sunday after recovering from a neck injury sustained against Newcastle Falcons back in November. In the second row George Skivington, fresh from the England Saxons, joins Shaw, and Dan Leo and John Hart are named alongside captain Betsen in the back row.
Wasps' only defeat in their last four games in the Guinness Premiership came at Sale at the end of December, while Leicester Tigers have not won away from home in the Premiership since a 19-17 victory at Worcester in September.
The Londoners have won the last three encounters between the two clubs since Leicester's 34-24 win in the semi-finals of the EDF Energy Cup at Millennium Stadium, Cardiff, on 22 March 2008.
The Tigers have visited Adams Park on seven previous occasions and have lost only once, on their first ever visit in December 2002.
Wasps: 15 Mark Van Gisbergen, 14 Chris Bishay, 13 Dominic Waldouck, 12 Josh Lewsey, 11 Tom Voyce, 10 Danny Cipriani, 9 Mark Robinson, 8 John Hart, 7 Serge Betsen (c), 6 Dan Leo, 5 George Skivington, 4 Simon Shaw, 3 Pat Barnard, 2 Rob Webber, 1 Tim Payne.
Replacements: 16 Joe Ward, 17 Tom French, 18 Richard Birkett, 19 Hugo Ellis, 20 Joe Simpson, 21 Dave Walder, 22 Rob Hoadley.
Leicester: 15 Scott Hamilton, 14 Matt Smith, 13 Seru Rabeni, 12 Aaron Mauger (c), 11 Alesana Tuilagi, 10 Sam Vesty, 9 Julien Dupuy, 8 Jordan Crane, 7 Ben Woods, 6 Craig Newby, 5 Ben Kay, 4 Louis Deacon, 3 Dan Cole, 2 George Chuter, 1 Boris Stankovich.
Replacements: 16 Mefin Davies, 17 Marcos Ayerza, 18 Martin Corry, 19 Brett Deacon, 20 Ben Youngs, 21 Ayoola Erinle, 22 Johne Murphy.
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|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale Sharks vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com