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Sale chief Kingsley Jones has named a strong looking line-up for the Heineken Cup clash with Harlequins on Sunday.
The Sharks have Dwayne Peel, Mark Cueto, Lee Thomas and Chris Jones all available for the clash - although Jones is without Dean Schofield and Kristian Ormsby.
Speaking exclusively to skysports.com ahead of the game, Jones said: "I'm really looking forward to it - the Heineken Cup is where everyone wants to be coaching and playing.
"It's a massive tournament, the shop window if you like, a break from the Premiership and although we are up against an English team it's a different tournament and we are back on the road down to London.
"We expect a high-intensity game, they play with tempo, pace, they've got some key players back from injury and into form and it will be a challenge, but that's what we are all about."
Sale have won 11 of the last 15 matches between the sides, and Jones is determined to maintain the club's fine record over Quins.
"To be honest with you, I don't think you can read too much into records. It does give you a bit of confidence as you think 'well we can go down here and win' but on the other side of that it gives Quins the edge by saying 'we want to stop this record'.
"We are confident that we can go down there and get a result but we know we have to be at our best. They are improving a lot, they are one of the most improved sides in the Premiership, probably due to the fact Nick Easter and Danny Care are back, although I understand he is suspended, and Nick Evans is back at 10.
"I have watched their last two or three games and they are playing with a lot of tempo, pace, they can score tries from nothing and it's a big challenge. We can probably play a similar style of rugby at our best and that's probably why we've done well there.
"It's a big game for both teams, Quins will effectively be out if they lose this game."
Will Skinner will return to skipper Harlequins for the visit of Sale.
Skinner joins Chris Robshaw and Nick Easter in the back-row - with Quins making seven changes to the side that beat Leeds.
Lewis Stevenson comes into the second row for the injured James Percival, while Chris Brooker gets the nod ahead of Tani Fuga for the hooker's jersey.
In the backs, George Lowe starts in the centres after Nils Mordt was ruled out through injury, while Ugo Monye has recovered from illness to start on the wing.
Mike Brown is restored to full-back, while Danny Care's suspension means Karl Dickson starts at scrum-half.
Harlequins: 15 Mike Brown, 14 David Strettle, 13 Gonzalo Tiesi, 12 George Lowe, 11 Ugo Monye, 10 Nick Evans, 9 Karl Dickson, 1 Ceri Jones, 2 Chris Brooker, 3 John Andress, 4 Lewis Stevenson, 5 George Robson, 6 Chris Robshaw, 7 Will Skinner, 8 Nick Easter.
Replacements: 16 Tani Fuga, 17 Aston Croall, 18 Mark Lambert, 19 Neil McMillan, 20 Tom Guest, 21 Steve So'oialo, 22 Rory Clegg, 23 Tom Williams.
Sale: 15 Nick Macleod, 14 Mark Cueto, 13 Mathew Tait, 12 Lee Thomas, 11 Ben Cohen, 10 Charlie Hodgson (capt), 9 Dwayne Peel, 8 Sisa Koyamaibole, 7 David Seymour, 6 Carl Fearns, 5 Sean Cox, 4 James Gaskell, 3 Jack Forster, 2 Neil Briggs, 1 Eifion Roberts.
Replacements: 16 Marc Jones, 17 Gavin Kerr, 18 Martin Halsall, 19 Chris Jones, 20 Luke Abraham, 21 Richard Wigglesworth, 22 David Bishop, 23 Oriol Ripol.
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Read the thoughts and opinions of Stuart Barnes with skysports.com