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Gloucester head coach Bryan Redpath has been boosted by the return of captain Mike Tindall for Saturday's Aviva Premiership clash with Harlequins.
Tindall returns after being rested for the visit of Rovigo last weekend and will partner Henry Trinder in the midfield.
Trinder is set for a third start in a row as he proves to be a more than able alternative for injured duo Eliota Fuimaono-Sapolu and Tim Molenaar.
Welsh international fly-half Nicky Robinson is back at No.10 and Charlie Sharples is preferred to Lesley Vainikolo on the wing.
In the pack, there are just two changes from the side that started against the Italians last weekend with Nick Wood and Brett Deacon both restored to the starting line-up.
With Gloucester currently in fifth place in the table and Harlequins in seventh, but level on points, there is plenty at stake as the sides meet for the first time this season.
Redpath admitted that he respects the visitors and the quality in their side but that Gloucester are focussing on their own game.
"Quins are a dangerous side. They've got probably one of the best eight, nine and ten combinations in the Premiership and you can't disregard that," he said.
"But we've got to focus on what we are and how we impose ourselves on Harlequins. We have to execute well, we have to defend well. If we do that, then we'll be in the game.
"It could be quite open. That's the nature of the two sides, we both like to play and to attack. It could come down to who defends worst, loses the game."
Meanwhile, after back-to-back wins in the league, Harlequins will be keen to continue their winning ways in the competition when they go to Kingsholm.
There are a number of changes to the side that earned a bonus point win against Cavalieri Prato last week in the Amlin Challenge Cup.
Up front, Joe Marler, Chris Brooker and John Andress make up the front-row, with Tomas Vallejos and George Robson combining in the second row. Will Skinner, the only player remaining from last week's pack, is joined by Nick Easter and captain, Chris Robshaw.
Nick Evans takes his place back in the driving seat, linking once again with Danny Care at scrum-half. Gonzalo Camacho and Tom Williams retain their places on the wings, along with George Lowe in the centre. Jordan Turner-Hall returns to join Lowe in the centres after a two-week injury absence and Mike Brown finalises the starting line-up at full-back.
The absence of James Johnston from the match day squad is due to the sudden and tragic death of his sister.
Gloucester: 15 Olly Morgan, 14 Charlie Sharples, 13 Mike Tindall (capt), 12 Henry Trinder, 11 James Simpson-Daniel, 10 Nicky Robinson, 9 Dave Lewis, 8 Brett Deacon, 7 Andy Hazell, 6 Alasdair Strokosch, 5 Alex Brown, 4 Jim Hamilton, 3 Paul Doran-Jones, 2 Scott Lawson, 1 Nick Wood.
Replacements: 16 Olivier Azam, 17 Alasdair Dickinson, 18 Pierre Capdevielle, 19 Dave Attwood, 20 Luke Narraway, 21 Jordi Pasqualin, 22 Freddie Burns, 23 Lesley Vainikolo.
Harlequins: 15 Mike Brown, 14 Tom Williams, 13 George Lowe, 12 Jordan Turner-Hall, 11 Gonzalo Camacho, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Will Skinner, 6 Chris Robshaw (capt), 5 George Robson, 4 Tomas Vallejos, 3 John Andress, 2 Chris Brooker, 1 Joe Marler.
Replacements: 16 Joe Gray, 17 Ceri Jones, 18 Mark Lambert, 19 Peter Browne, 20 Tom Guest, 21 Karl Dickson, 22 Rory Clegg, 23 Ollie Smith.
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|Friday 20th December|
|20:00||Sale Sharks vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:00||Saracens vs Leicester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|15:00||Leicester vs Bath|
|Sunday 5th January|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Bath vs Newcastle|
|15:00||Exeter vs Northampton|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|15:00||Leicester vs Gloucester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
|Sunday 27th October|
|Newcastle 13 - 11 London Irish|
|Wasps 22 - 12 Leicester|
|Saturday 26th October|
|Northampton 41 - 20 Saracens|
|Exeter 40 - 6 Worcester|
|Harlequins 24 - 3 Sale Sharks|
|Friday 25th October|
|Bath 15 - 13 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com