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England flanker Tom Croft returns from injury to take his place on the Leicester bench for the visit of Wasps.
Croft will look to stake a claim for an international recall ahead of the RBS Six Nations clash with France by proving his fitness in the clash.
The Tigers will also welcome back Italy prop Martin Castrogiovanni and Boris Stankovich, but Jordan Crane, Ed Slater, Matt Smith, Julian White, Geordan Murphy, Ben Pienaar and Geoff Parling are all sidelined.
Director of rugby Richard Cockerill said: "We've got four tough games to play during this Six Nations period and, although we made a good start to that run with a win at Leeds last week, we want to keep it going.
"We've had some cracking games against Wasps in recent years and it should be a good contest.
"Julian White has had a bit of an injury but having Castro back softens the blow and I thought Pete Bucknall did an outstanding job for us at Leeds last weekend."
London Wasps coach Shaun Edwards has made five changes to the side in the wake of Tony Hanks' departure.
Mark Van Gisbergen, Nic Berry, Tom Lindsay, Marty Veale and Joe Launchbury all come into the side on the back of the defeat to Gloucester.
Wasps have picked up two wins from their past three visits to Welford Road, while they toppled the Tigers 37-30 at Adams Park earlier in the season.
Leicester: 15 Scott Hamilton, 14 Horacio Agulla, 13 Manu Tuilagi, 12 Anthony Allen, 11 Alesana Tuilagi, 10 Jeremy Staunton, 9 James Grindal, 8 Thomas Waldrom, 7 Ben Woods, 6 Craig Newby (capt), 5 George Skivington, 4 Steve Mafi, 3 Martin Castrogiovanni, 2 George Chuter, 1 Boris Stankovich.
Replacements: 16 Rob Hawkins, 17 Marcos Ayerza, 18 Peter Bucknall, 19 Calum Green, 20 Tom Croft, 21 Sam Harrison, 22 Dan Hipkiss, 23 Billy Twelvetrees.
Wasps: 15 Mark Van Gisbergen, 14 Richard Haughton, 13 Dominic Waldouck, 12 Riki Flutey, 11 Ben Jacob, 10 Dave Walder, 9 Nic Berry, 8 Joe Worsley, 7 Serge Betsen, 6 Joe Launchbury, 5 Richard Birkett (capt), 4 Marty Veale, 3 Ben Broster, 2 Tom Lindsay, 1 Tim Payne.
Replacements: 16 Joe Ward, 17 Shaun Ruwers, 18 Bob Baker, 19 James Cannon, 20 Sam Jones, 21 Joe Simpson, 22 Steve Kefu, 23 Jack Wallace.
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|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Wasps vs Newcastle|
|15:00||Exeter vs Harlequins|
|15:00||Sale vs Leicester|
|15:00||Saracens vs Worcester|
|15:00||Gloucester vs London Irish|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Harlequins vs Bath|
|15:15||Leicester vs Saracens|
|15:15||Worcester vs Gloucester|
|15:15||Northampton vs Wasps|
|15:15||London Irish vs Sale|
|Saturday 19th April|
|Wasps 38 - 30 Gloucester|
|Bath 32 - 20 Worcester|
|Exeter 12 - 55 Sale|
|Friday 18th April|
|Harlequins 24 - 20 Leicester|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
Read the thoughts and opinions of Stuart Barnes with skysports.com