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Saracens will welcome back international duo Chris Wyles and Michael Tagicakibau for the visit of Harlequins on Sunday.
Wyles and Tagicakibau have been away playing for the USA and Fiji respectively but they return to the starting XV.
With Kameli Ratuvou ruled out for six months, Tagicakibau has been named in the centres with Wyles starting at full-back.
Sarries also welcome back South African trio Mouritz Botha, Jacques Burger and Ernst Joubert to the pack with Scotland international Kelly Brown named on the bench.
Harlequins have opted against tinkering with their starting XV despite the return of their international contingent.
Quins toppled Leeds Carnegie 51-18 last time out, so Nick Easter, Danny Care and Gonzalo Camacho have to settle for a place on the bench.
Saracens: 15 Chris Wyles, 14 David Strettle, 13 Michael Tagicakibau, 12 Brad Barritt, 11 James Short, 10 Owen Farrell, 9 Richard Wigglesworth, 8 Ernst Joubert, 7 Andy Saull, 6 Jacques Burger, 5 Mouritz Botha, 4 Steve Borthwick (capt), 3 Carlos Nieto, 2 Schalk Brits, 1 Deon Carstens.
Replacements: 16 Jamie George, 17 Rhys Gill, 18 Petrus du Plessis, 19 George Kruis, 20 Kelly Brown, 21 Neil de Kock, 22 Nils Mordt, 23 Noah Cato.
Harlequins: 15 Mike Brown, 14 George Lowe, 13 Ollie Smith, 12 Jordan Turner-Hall, 11 Tom Williams, 10 Nick Evans, 9 Karl Dickson, 1 Joe Marler, 2 Joe Gray, 3 James Johnston, 4 Tomas Vallejos, 5 George Robson, 6 Chris Robshaw (c), 7 Will Skinner, 8 Tom Guest
Replacements: 16 Chris Brooker, 17 Ceri Jones, 18 Mark Lambert, 19 Ollie Kohn, 20 Nick Easter, 21 Danny Care, 22 Rory Clegg, 23 Gonzalo Camacho
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|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Saracens vs Worcester|
|15:00||Exeter vs Harlequins|
|15:00||Gloucester vs London Irish|
|15:00||Sale vs Leicester|
|15:00||Wasps vs Newcastle|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Leicester vs Saracens|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
Read the thoughts and opinions of Stuart Barnes with skysports.com