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London Irish welcome back Alex Corbisiero for Saturday's Aviva Premiership clash with Sale at the Reebok Stadium.
England prop Corbisiero makes his first start for the Exiles since returning from Six Nations duty.
David Paice, who has scored two tries in two games, starts at hooker and Romanian international Paulica Ion replaces Faan Rautenbach. Bob Casey rejoins Nick Kennedy in the second row while Seilala Mapusua captains the side.
"The whole squad is aware of the importance of Saturday's game with Sale Sharks," said London Irish head coach Toby Booth.
"There are only five points separating us for from fourth place, so we go to the Reebok Stadium knowing what we have to do and intend to come away with the right result."
Meanwhile, Carl Fearns has recovered from a knee injury and starts at openside flanker for Sale, while Will Addison makes his first Premiership start.
"This game is another example of the way the club is moving forward," said Sharks head coach Pete Anglesea of the move to Reebok Stadium.
"It's an exciting venture, with our biggest ever crowd for a home game. We're in confident mood, looking forward to successive wins."
Sale Sharks: 15 Nick Macleod, 14 Paul Williams, 13 Chris Bell, 12 Andy Tuilagi, 11Will Addison, 10 Charlie Hodgson (capt), 9Will Cliff, 8 Sisa Koyamaibole, 7 Carl Fearns, 6 James Gaskell, 5 Wame Lewaravu, 4 Sean Cox, 3 Henry Thomas, 2 Neil Briggs, 1 Eifion Lewis Roberts.
Replacements: 16 Marc Jones, 17 Lee Imiolek, 18 Andrew Sheridan, 19 Chris Jones, 20 Neil McMillan, 21 Dwayne Peel, 22 Rob Miller, 23 Kyle Tonetti.
London Irish: 15 Delon Armitage, 14 Topsy Ojo, 13 Elvis Seveali'i, 12 Seilala Mapusua (captain), 11 Tom Homer, 10 Dan Bowden, 9 Paul Hodgson, 8 George Stowers 7 Steffon Armitage, 6 Jamie Gibson, 5 Bob Casey, 4 Nick Kennedy, 3 Paulica Ion, 2 David Paice, 1 Alex Corbisiero.
Replacements: 16 James Buckland, 17 Clarke Dermody, 18 Faan Rautenbach, 19 Gary Johnson, 20 Richard Thorpe, 21 Jonathan Joseph, 22 Chris Malone, 23 Darren Allinson.
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|Saturday 25th May|
|15:00||Leicester vs Northampton|
|Sunday 12th May|
|Saracens 13 - 27 Northampton|
|Saturday 11th May|
|Leicester 33 - 16 Harlequins|
|Saturday 4th May|
|Leicester 32 - 20 London Irish|
|London Welsh 33 - 22 Worcester|
|Harlequins 22 - 19 Northampton|
|Sale 21 - 20 Wasps|
|Exeter 40 - 39 Gloucester|
|Saracens 23 - 14 Bath|
|Sunday 21st April|
|Wasps 24 - 37 Exeter|
|Saturday 20th April|
|Northampton 47 - 7 Sale|
|Gloucester 28 - 23 Saracens|
|London Irish 47 - 28 London Welsh|
|Worcester 26 - 42 Harlequins|
|Bath 27 - 26 Leicester|
|Sunday 14th April|
|Leicester 35 - 16 Wasps|
|Saracens 47 - 17 Worcester|
|London Welsh 14 - 31 Northampton|
|Saturday 13th April|
|Exeter 27 - 6 London Irish|
|Harlequins 23 - 9 Bath|
|Friday 12th April|
|Sale 32 - 9 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com