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Northampton boss Jim Mallinder has rejigged his side ahead of the Aviva Premiership clash with London Irish at Franklin's Gardens on Saturday.
Although the Saints beat Gloucester in their first match of the season, the trip to Harlequins a week later ended in a 26-13 defeat.
Mallinder has responded by shuffling his back division, with Jon Clarke moving from centre to full-back to replace Greg Tonks and Paul Diggin returning on the wing.
Tom May moves off the wing to take Clarke's place in the midfield, while Ryan Lamb replaces Stephen Myler at fly-half.
Brett Sharman and Tom Mercey come into the front row for Andy Long and Brian Mujati respectively, while the rest of the pack remains unchanged.
Mallinder says that the Saints need to reduce their error count if they are to bounce back with victory over the Exiles.
"We were not good enough at the Stoop and made far too many mistakes against what is a very good Harlequins outfit," he said.
"We will have to cut those out if we are to get a good result against a tough London Irish team tomorrow."
London Irish coach Toby Booth has made two changes to the starting XV that were edged out 30-29 by Sale last Friday.
Adam Thompstone will start on the wing after coming off the bench against the Sharks, while Ed Siggery is handed a full competitive debut at blindside flanker.
New signing Bryn Evans has been named as a replacement after arriving from New Zealand and academy prospect Anthony Watson is also included on the bench.
Booth said: "We have been competitive in the opening two games and there have been positives to come out of them; however, we want to be winning close encounters when they are there for the taking."
Northampton: 15 Jon Clarke, 14 Paul Diggin, 13 Tom May, 12 James Downey, 11 Noah Cato, 10 Ryan Lamb, 9 Martin Roberts, 8 Phil Dowson (c), 7 Ben Nutley, 6 Calum Clark, 5 Christian Day, 4 Samu Manoa, 3 Tom Mercey, 2 Brett Sharman, 1 Alex Waller.
Replacements: 16 Andy Long, 17 Paul Doran Jones, 18 Brian Mujati, 19 Mark Sorenson, 20 James Craig, 21 Stuart Commins, 22 Stephen Myler.
London Irish: 15 Tom Homer, 14 Topsy Ojo, 13 Jonathan Joseph, 12 Steve Shingler, 11 Adam Thompstone, 10 Dan Bowden, 9 Darren Allinson, 8. Chris Hala'ufia, 7 Alex Gray, 6 Ed Siggery, 5 Matt Garvey, 4 Nick Kennedy, 3 Leo Halavatau, 2 David Paice, 1 Clarke Dermody (c).
Replacements: 16 James Buckland, 17 Max Lahiff, 18 Mark George, 19 Bryn Evans, 20 Dave Sisi, 21 Guy Armitage, 22 Anthony Watson, 23 Paul Hodgson.
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|Friday 20th December|
|20:00||Sale Sharks vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:00||Saracens vs Leicester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|15:00||Leicester vs Bath|
|Sunday 5th January|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Bath vs Newcastle|
|15:00||Exeter vs Northampton|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|15:00||Leicester vs Gloucester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
|Sunday 27th October|
|Newcastle 13 - 11 London Irish|
|Wasps 22 - 12 Leicester|
|Saturday 26th October|
|Northampton 41 - 20 Saracens|
|Exeter 40 - 6 Worcester|
|Harlequins 24 - 3 Sale Sharks|
|Friday 25th October|
|Bath 15 - 13 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com