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Harlequins return to Aviva Premiership action against London Irish on Saturday at the Stoop and welcome back Matt Hopper from England Saxons duty.
It will be the first home league assignment for Conor O'Shea's men since beating Newcastle at the end of November last year.
Ross Chisholm retains his place at full-back from last weekend's high-scoring defeat at Cardiff Blues, alongside Sam Smith and the returning Tom Williams who line up on the wings.
Hopper returns from Saxons duty to partner Tom Casson in the centre, outside half-back pairing Nick Evans and Danny Care.
Mark Lambert, Joe Gray and James Johnston all return to provide the foundation of the scrum. Olly Kohn again partners George Robson in the second row, with Robson taking over the captaincy from Chris Robshaw who will lead England in Rome.
Tom Guest, Luke Wallace and Nick Easter provide the back row, with the likes of Tomas Vallejos, Will Skinner, Rory Clegg and George Lowe providing back-up from the bench.
The Exiles have made five changes from the side that beat Gloucester last weekend for the trip across the capital.
Topsy Ojo is back on the wing with Jonathan Joseph partnering Shontayne Hape in the centres.
Up front, David Paice and Faan Rautenbach are installed in the front row with Kieran Roche taking his place in the back three alongside Richard Thorpe and Matt Garvey.
"It is important that we continue the momentum we gained from last weekend and play with the attacking intent we have shown in recent weeks," stated London Irish head coach Toby Booth.
"Points are crucial at this time of the season as we continue to push for a play-off position. The players have prepared well this week despite the weather and are ready for the contest."
Harlequins: 15 Ross Chisholm, 14 Tom Williams, 13 Matt Hopper, 12 Tom Casson, 11 Sam Smith, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Luke Wallace, 6 Tom Guest, 5 George Robson (c), 4 Olly Kohn, 3 James Johnston, 2 Joe Gray, 1 Mark Lambert
Replacements: 16 Chris Brooker, 17 Aston Croall, 18 Tim Fairbrother, 19 Tomas Vallejos, 20 Will Skinner, 21 Karl Dickson, 22 Rory Clegg, 23 George Lowe.
London Irish:: 15 Tom Homer, 14 Topsy Ojo, 13 Jonathan Joseph, 12 Shontayne Hape, 11 Sailosi Tagicakibau, 10 Dan Bowden, 9 Darren Allinson, 1 Clarke Dermody (capt), 2 David Paice, 3 Faan Rautenbach, 4 Nick Kennedy, 5 Bryn Evans, 6 Matt Garvey, 7 Kieran Roche, 8 Richard Thorpe
Replacements: 16 Brian Blaney, 17 Max Lahiff, 18 Paulica Ion, 19 Ed Siggery, 20 Marland Yarde, 21 Delon Armitage, 22 Adrian Jarvis, 23 Ross Samson.
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|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com