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Harlequins have made two enforced changes to their starting XV for the Gloucester's visit to the Stoop on Saturday.
Sam Smith will play on the wing in place of Ross Chisholm, who will be sidelined for a number of weeks with an ankle injury.
Joe Marler is unavailable after being given a three-week ban for striking, meaning Mark Lambert is brought into the line-up at prop. The rest of the pack remains unchanged from last Friday's win over Northampton.
Quins will be looking to continue a run of form that has seen them win five of their last six matches in all competitions, with their only defeat in that period being a 13-16 defeat to Saracens in May.
Gloucester hand a first start to Australian hooker Nathan Charles as coach Bryan Redpath makes several changes to the line-up that comfortably defeated Worcester.
Charles will start in the front row alongside Nick Wood and Rupert Harden, who comes into the team for Dario Chistolini at tighthead.
With Will James banned for one match, Tom Savage keeps his place at lock, with Alex Brown joining him in the second row having missed out at home to the Warriors last weekend.
Brett Deacon will make his first start of the season at No. 8 and Matt Cox moves to openside flanker as Andy Hazell is absent due to a thumb injury.
There are also changes in the backs, with Henry Trinder starting at outside centre in place of Jonny May, who is dropped to the bench, while Freddie Burns is preferred to Tim Taylor at fly-half.
Harlequins: 15 Mike Brown, 14 Sam Smith, 13 George Lowe, 12 Jordan Turner-Hall, 11 Ugo Monye, 10 Nick Evans, 9 Karl Dickson, 8 Chris York, 7 Luke Wallace, 6 Chris Robshaw (c), 5 George Robson, 4 Ollie Kohn, 3 Tim Fairbrother, 2 Joe Gray, 1 Mark Lambert.
Replacements: 16 Chris Brooker, 17 Darryl Marfo, 18 James Johnston, 19 Charlie Matthews, 20 Joe Trayfoot, 21 Richard Bolt, 22 Rory Clegg, 23 Charlie Walker.
Gloucester: 15 Olly Morgan, 14 Charlie Sharples, 13 Henry Trinder, 12 Lesley Vainikolo, 11 Tom Voyce, 10 Freddie Burns, 9 Nick Runciman, 8 Brett Deacon, 7 Matt Cox, 6 Peter Buxton (c), 5 Alex Brown, 4 Tom Savage, 3 Rupert Harden, 2 Nathan Charles, 1 Nick Wood.
Replacements: 16 Darren Dawidiuk, 17 Dan Murphy, 18 Dario Chistolini, 19 Dave Lyons, 20 Gareth Evans, 21 Dan Robson, 22 Tim Taylor, 23 Jonny May.
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|Friday 20th December|
|19:45||Sale vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:15||Saracens vs Leicester|
|Sunday 22nd December|
|14:00||Gloucester vs Worcester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|Sunday 5th January|
|14:00||Leicester vs Bath|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Exeter vs Northampton|
|15:00||Bath vs Newcastle|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
Read the thoughts and opinions of Stuart Barnes with skysports.com