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|Home team||Away Team|
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The Bulls have included Francois Hougaard and Johann Sadie in their line-up for Saturday's clash with the Reds.
Hougaard missed the third round defeat to the Blues due to suspension but he returns to replace the benched Jano Vermaak.
Sadie, who was absent from the previous two matches after suffering from a shoulder injury, replaces Francois Venter at outside centre.
Coach Frans Ludeke has admitted the Reds will be the biggest challenge his side has faced so far this season.
"They are the champions and that will be how high the bar will be set. We will have to deliver a championship performance if we want to beat them," he said.
"The effort against the Blues was below par and we know that. We worked hard to be accurate on the weekend and to create and convert chances."
The Reds have made several changes ahead of Saturday's clash, with a first start for fly-half Dallan Murphy.
The 23-year-old will earn his second Super Rugby cap, making his debut in 2011 against the Chiefs, after successful campaigns as captain of Brothers and various Queensland A squads.
Coach Ewan McKenzie said: "Dallan has been in our system for a long time and we have every confidence in his ability to get the job done. We've played around with our options at fly-half this year but Dallan is a natural number 10 so I'm looking forward to seeing what he can offer."
The 2011 Super Rugby champions have made seven changes following their 22-27 loss to the Sharks last weekend, bringing a revamped side to Pretoria.
McKenzie has transformed the Reds' front-row with Hooker Saia Faingaa making his first start of the year, moving Greg Holmes to tight-head and Ben Daley promoted from the bench to loose-head.
Luke Morahan steps in for suspended winger Digby Loane, while forwards Rob Simmons and Jake Schatz regain their spots at lock and number eight respectively.
Ben Tapuai moves to inside centre, with Jono Lance at outside centre, and outside back Nathan Eyres-Brown could earn his Super Rugby debut after being put on the bench.
Bulls: 15 Zane Kirchner, 14 Akona Ndungane, 13 Johann Sadie, 12 Wynand Olivier, 11 Bjorn Basson, 10 Morné Steyn, 9 Francois Hougaard, 8 Pierre Spies (c), 7 Jacques Potgieter, 6 CJ Stander, 5 Juandré Kruger, 4 Flip van der Merwe, 3 Werner Kruger, 2 Chiliboy Ralepelle, 1 Dean Greyling.
Replacements: 16 Willie Wepener, 17 Frik Kirsten, 18 Wilhelm Steenkamp, 19 Arno Botha, 20 Jano Vermaak, 21 Louis Fouché, 22 JJ Engelbrecht.
Reds: 15 Rod Davies, 14 Dom Shipperley, 13 Jono Lance, 12 Ben Tapuai, 11 Luke Morahan, 10 Dallan Murphy, 9 Will Genia, 8 Jake Schatz, 7 Beau Robinson, 6 Scott Higginbotham, 5 James Horwill (c), 4 Rob Simmons, 3 Greg Holmes, 2 Saia Faingaa, 1 Ben Daley.
Replacements: 16 James Hanson, 17 James Slipper, 18 Radike Samo, 19 Van Humphries, 20 Liam Gill, 21 Nick Frisby, 22 Nathan Eyres-Brown.
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|Friday 18th April|
|08:35||Hurricanes vs Blues|
|10:40||Melbourne Rebels vs Western Force|
|Saturday 19th April|
|08:35||Chiefs vs Crusaders|
|10:40||Waratahs vs Bulls|
|14:00||Sharks vs Cheetahs|
|16:05||Stormers vs Lions|
|Friday 25th April|
|06:35||Blues vs Waratahs|
|08:40||Brumbies vs Chiefs|
|18:10||Sharks vs Highlanders|
|Saturday 26th April|
|08:35||Hurricanes vs Reds|
|10:40||Western Force vs Bulls|
|16:05||Cheetahs vs Stormers|
|Friday 2nd May|
|08:35||Blues vs Reds|
|10:40||Melbourne Rebels vs Sharks|
|Saturday 3rd May|
|08:35||Crusaders vs Brumbies|
|08:35||Chiefs vs Lions|
|10:40||Waratahs vs Hurricanes|
|14:00||Stormers vs Highlanders|
|16:05||Bulls vs Cheetahs|
|Friday 9th May|
|08:35||Chiefs vs Blues|
|10:40||Melbourne Rebels vs Hurricanes|
|Saturday 10th May|
|08:35||Highlanders vs Lions|
|10:40||Brumbies vs Sharks|
|16:05||Cheetahs vs Western Force|
|18:10||Bulls vs Stormers|
|Saturday 12th April|
|Lions 12 - 25 Sharks|
|Cheetahs 31 - 52 Crusaders|
|Western Force 28 - 16 Waratahs|
|Chiefs 22 - 16 Melbourne Rebels|
|Friday 11th April|
|Reds 20 - 23 Brumbies|
|Highlanders 27 - 20 Bulls|
|Saturday 5th April|
|Stormers 11 - 22 Waratahs|
|Lions 7 - 28 Crusaders|
|Cheetahs 43 - 43 Chiefs|
|Reds 29 - 32 Western Force|
|Hurricanes 25 - 20 Bulls|
|Friday 4th April|
|Brumbies 26 - 9 Blues|
|Highlanders 33 - 30 Melbourne Rebels|
|Saturday 29th March|
|Sharks 32 - 10 Waratahs|
|Bulls 34 - 34 Chiefs|
|Reds 22 - 17 Stormers|
|Blues 30 - 12 Highlanders|
|Friday 28th March|
|Melbourne Rebels 32 - 24 Brumbies|
|Crusaders 26 - 29 Hurricanes|
|Saturday 22nd March|
|Bulls 23 - 19 Sharks|
|Lions 23 - 20 Reds|
|Western Force 18 - 15 Chiefs|
|Brumbies 25 - 15 Stormers|
|Blues 40 - 30 Cheetahs|
|Friday 21st March|
|Waratahs 32 - 8 Melbourne Rebels|
Read the thoughts and opinions of Stuart Barnes with skysports.com