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|Home team||Away Team|
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The Bulls have included Francois Hougaard and Johann Sadie in their line-up for Saturday's clash with the Reds.
Hougaard missed the third round defeat to the Blues due to suspension but he returns to replace the benched Jano Vermaak.
Sadie, who was absent from the previous two matches after suffering from a shoulder injury, replaces Francois Venter at outside centre.
Coach Frans Ludeke has admitted the Reds will be the biggest challenge his side has faced so far this season.
"They are the champions and that will be how high the bar will be set. We will have to deliver a championship performance if we want to beat them," he said.
"The effort against the Blues was below par and we know that. We worked hard to be accurate on the weekend and to create and convert chances."
The Reds have made several changes ahead of Saturday's clash, with a first start for fly-half Dallan Murphy.
The 23-year-old will earn his second Super Rugby cap, making his debut in 2011 against the Chiefs, after successful campaigns as captain of Brothers and various Queensland A squads.
Coach Ewan McKenzie said: "Dallan has been in our system for a long time and we have every confidence in his ability to get the job done. We've played around with our options at fly-half this year but Dallan is a natural number 10 so I'm looking forward to seeing what he can offer."
The 2011 Super Rugby champions have made seven changes following their 22-27 loss to the Sharks last weekend, bringing a revamped side to Pretoria.
McKenzie has transformed the Reds' front-row with Hooker Saia Faingaa making his first start of the year, moving Greg Holmes to tight-head and Ben Daley promoted from the bench to loose-head.
Luke Morahan steps in for suspended winger Digby Loane, while forwards Rob Simmons and Jake Schatz regain their spots at lock and number eight respectively.
Ben Tapuai moves to inside centre, with Jono Lance at outside centre, and outside back Nathan Eyres-Brown could earn his Super Rugby debut after being put on the bench.
Bulls: 15 Zane Kirchner, 14 Akona Ndungane, 13 Johann Sadie, 12 Wynand Olivier, 11 Bjorn Basson, 10 Morné Steyn, 9 Francois Hougaard, 8 Pierre Spies (c), 7 Jacques Potgieter, 6 CJ Stander, 5 Juandré Kruger, 4 Flip van der Merwe, 3 Werner Kruger, 2 Chiliboy Ralepelle, 1 Dean Greyling.
Replacements: 16 Willie Wepener, 17 Frik Kirsten, 18 Wilhelm Steenkamp, 19 Arno Botha, 20 Jano Vermaak, 21 Louis Fouché, 22 JJ Engelbrecht.
Reds: 15 Rod Davies, 14 Dom Shipperley, 13 Jono Lance, 12 Ben Tapuai, 11 Luke Morahan, 10 Dallan Murphy, 9 Will Genia, 8 Jake Schatz, 7 Beau Robinson, 6 Scott Higginbotham, 5 James Horwill (c), 4 Rob Simmons, 3 Greg Holmes, 2 Saia Faingaa, 1 Ben Daley.
Replacements: 16 James Hanson, 17 James Slipper, 18 Radike Samo, 19 Van Humphries, 20 Liam Gill, 21 Nick Frisby, 22 Nathan Eyres-Brown.
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|Friday 24th May|
|08:35||Chiefs vs Crusaders|
|10:40||Melbourne Rebels vs Waratahs|
|Saturday 25th May|
|08:35||Blues vs Brumbies|
|10:40||Western Force vs Highlanders|
|16:00||Southern Kings vs Cheetahs|
|16:05||Stormers vs Reds|
|18:10||Sharks vs Bulls|
|Friday 31st May|
|08:35||Crusaders vs Waratahs|
|10:40||Brumbies vs Hurricanes|
|Saturday 1st June|
|08:35||Highlanders vs Blues|
|10:40||Reds vs Melbourne Rebels|
|16:05||Stormers vs Southern Kings|
|18:10||Cheetahs vs Bulls|
|Friday 7th June|
|10:40||Brumbies vs Melbourne Rebels|
|Sunday 9th June|
|07:05||Western Force vs Waratahs|
|Friday 28th June|
|08:35||Chiefs vs Hurricanes|
|Saturday 29th June|
|08:35||Highlanders vs Crusaders|
|14:00||Sharks vs Blues|
|16:05||Bulls vs Southern Kings|
|18:10||Stormers vs Cheetahs|
|Friday 5th July|
|08:35||Crusaders vs Chiefs|
|Saturday 6th July|
|08:35||Hurricanes vs Highlanders|
|14:00||Cheetahs vs Blues|
|16:05||Southern Kings vs Stormers|
|18:10||Bulls vs Sharks|
|Saturday 18th May|
|Cheetahs 27 - 13 Reds|
|Bulls 35 - 18 Highlanders|
|Waratahs 28 - 22 Brumbies|
|Crusaders 23 - 3 Blues|
|Friday 17th May|
|Western Force 13 - 23 Sharks|
|Melbourne Rebels 30 - 21 Stormers|
|Hurricanes 12 - 17 Chiefs|
|Saturday 11th May|
|Southern Kings 34 - 27 Highlanders|
|Waratahs 21 - 15 Stormers|
|Blues 36 - 32 Melbourne Rebels|
|Friday 10th May|
|Cheetahs 34 - 39 Hurricanes|
|Reds 32 - 17 Sharks|
|Chiefs 22 - 21 Western Force|
|Sunday 5th May|
|Brumbies 23 - 30 Crusaders|
|Saturday 4th May|
|Bulls 48 - 14 Hurricanes|
|Southern Kings 10 - 72 Waratahs|
|Western Force 11 - 11 Reds|
|Highlanders 25 - 22 Sharks|
|Friday 3rd May|
|Melbourne Rebels 33 - 39 Chiefs|
|Blues 18 - 17 Stormers|
|Sunday 28th April|
|Crusaders 30 - 26 Melbourne Rebels|
|Saturday 27th April|
|Cheetahs 26 - 12 Southern Kings|
|Bulls 30 - 19 Waratahs|
|Brumbies 41 - 7 Western Force|
|Chiefs 37 - 29 Sharks|
Read the thoughts and opinions of Stuart Barnes with skysports.com