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The Highlanders will look to climb back into the top-six places when they tackle the Bulls in Dunedin.
After a great start to the season, Jamie Joseph's side have dropped out of the play-off places - and things will not get any easier against the table toppers.
Joseph has made four changes for the clash - with Jamie Mackintosh, Jason Rutledge and Tim Boys replacing the rested Chris King, Andrew Hore and Josh Bekhuis.
In the backs, Mike Delany returns at fly-half in place of Chris Noakes.
The Bulls, who have won eight of their 10 matches, have made three changes - with Wynand Olivier, Dewald Potgieter and Dean Greyling called into the starting XV. Francois Venter, Deon Stegmann and Dawie Steyn all make way.
The match will see Morne Steyn make his 100th Super Rugby appearance for the Bulls - with the Springbok fly-half having passed the magical 1,000-point barrier this season.
The Round 13 clash at Forsyth Barr Stadium will see Steyn become the sixth player from the franchise to reach a century of Super Rugby matches.
Highlanders: 15 Ben Smith, 14 Siale Piutau, 13 Tamati Ellison, 12 Phil Burleigh, 11 Hosea Gear, 10 Mike Delany, 9 Aaron Smith, 8 Nasi Manu, 7 Tim Boys, 6 Adam Thomson, 5 Nick Crosswell, 4 Jarrad Hoeata, 3 Ma'afu Fia, 2 Jason Rutledge, 1 Jamie Mackintosh (capt).
Replacements: 16 Andrew Hore, 17 Bronson Murray, 18 Hoani MacDonald/Josh Bekhuis, 19 Scott Fuglistaller, 20 Jimmy Cowan, 21 Chris Noakes, 22 Kenny Lynn.
Bulls: 15 Zane Kirchner, 14 Akona Ndungane, 13 Johann Sadie, 12 Wynand Olivier, 11 Bjorn Basson, 10 Morne Steyn, 9 Francois Hougaard, 8 Pierre Spies (c), 7 CJ Stander, 6 Dewald Potgieter, 5 Juandre Kruger, 4 Flip van der Merwe, 3 Werner Kruger, 2 Chiliboy Ralepelle, 1 Dean Greyling.
Replacements: 16 Willie Wepener, 17 Rayno Gerber, 18 Wilhelm Steenkamp, 19 Arno Botha, 20 Jano Vermaak, 21 Louis Fouché, 22 JJ Engelbrecht.
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|Friday 24th May|
|08:35||Chiefs vs Crusaders|
|10:40||Melbourne Rebels vs Waratahs|
|Saturday 25th May|
|08:35||Blues vs Brumbies|
|10:40||Western Force vs Highlanders|
|14:00||Southern Kings vs Cheetahs|
|16:05||Stormers vs Reds|
|18:10||Sharks vs Bulls|
|Friday 31st May|
|08:35||Crusaders vs Waratahs|
|10:40||Brumbies vs Hurricanes|
|Saturday 1st June|
|08:35||Highlanders vs Blues|
|10:40||Reds vs Melbourne Rebels|
|16:05||Stormers vs Southern Kings|
|18:10||Cheetahs vs Bulls|
|Friday 7th June|
|10:40||Brumbies vs Melbourne Rebels|
|Sunday 9th June|
|07:05||Western Force vs Waratahs|
|Friday 28th June|
|08:35||Chiefs vs Hurricanes|
|Saturday 29th June|
|08:35||Highlanders vs Crusaders|
|14:00||Sharks vs Blues|
|16:05||Bulls vs Southern Kings|
|18:10||Stormers vs Cheetahs|
|Friday 5th July|
|08:35||Crusaders vs Chiefs|
|Saturday 6th July|
|08:35||Hurricanes vs Highlanders|
|14:00||Cheetahs vs Blues|
|16:05||Southern Kings vs Stormers|
|18:10||Bulls vs Sharks|
|Saturday 18th May|
|Cheetahs 27 - 13 Reds|
|Bulls 35 - 18 Highlanders|
|Waratahs 28 - 22 Brumbies|
|Crusaders 23 - 3 Blues|
|Friday 17th May|
|Western Force 13 - 23 Sharks|
|Melbourne Rebels 30 - 21 Stormers|
|Hurricanes 12 - 17 Chiefs|
|Saturday 11th May|
|Southern Kings 34 - 27 Highlanders|
|Waratahs 21 - 15 Stormers|
|Blues 36 - 32 Melbourne Rebels|
|Friday 10th May|
|Cheetahs 34 - 39 Hurricanes|
|Reds 32 - 17 Sharks|
|Chiefs 22 - 21 Western Force|
|Sunday 5th May|
|Brumbies 23 - 30 Crusaders|
|Saturday 4th May|
|Bulls 48 - 14 Hurricanes|
|Southern Kings 10 - 72 Waratahs|
|Western Force 11 - 11 Reds|
|Highlanders 25 - 22 Sharks|
|Friday 3rd May|
|Melbourne Rebels 33 - 39 Chiefs|
|Blues 18 - 17 Stormers|
|Sunday 28th April|
|Crusaders 30 - 26 Melbourne Rebels|
|Saturday 27th April|
|Cheetahs 26 - 12 Southern Kings|
|Bulls 30 - 19 Waratahs|
|Brumbies 41 - 7 Western Force|
|Chiefs 37 - 29 Sharks|
Read the thoughts and opinions of Stuart Barnes with skysports.com