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There will be a repeat of the 2011 Aviva Premiership final on Saturday when Leicester and Saracens clash for a place in this season's Twickenham showpiece.
Leicester have not enjoyed the best of times against Saracens in recent years - with Mark McCall's men having won three in a row at Welford Road, including a six-try rout earlier in the season, as well as the final last year.
However the Tigers will be buoyed by the return of Ben Youngs, George Skivington and Graham Kitchener to the squad, while George Chuter will make his 200th starting appearance for the club.
Saracens welcome back Charlie Hodgson, Will Fraser and Matt Stevens to their line-up.
Hodgson's inclusion means Owen Farrell starts in the centres, Chris Wyles moves to the wing and James Short drops to the bench.
"It's a massive match," said McCall.
"We've had a very good week of preparation but we know it is going to be a very tough game and we will have to be at our best to get the result we want.
"Leicester have a phenomenal semi-final record but we have had some excellent performances in recent weeks with wins against London Irish, Newcastle Falcons and Exeter Chiefs so we are really looking forward to the match."
Leicester: 15 Geordan Murphy (capt), 14 Horacio Agulla, 13 Manusamoa Tuilagi, 12 Anthony Allen, 11 Alesana Tuilagi, 10 Toby Flood, 9 Ben Youngs, 8 Thomas Waldrom, 7 Julian Salvi, 6 Steve Mafi, 5 Geoff Parling, 4 George Skivington, 3 Dan Cole, 2 George Chuter, 1 Marcos Ayerza.
Replacements: 16 Tom Youngs, 17 Logovi'i Mulipola, 18 Martin Castrogiovanni, 19 Graham Kitchener, 20 Craig Newby, 21 Sam Harrison, 22 Billy Twelvetrees, 23 Scott Hamilton.
Saracens: 15 Alex Goode, 14 David Strettle, 13 Owen Farrell, 12 Brad Barritt, 11 Chris Wyles, 10 Charlie Hodgson, 9 Neil de Kock, 8 Ernst Joubert, 7 Will Fraser, 6 Jackson Wray, 5 Mouritz Botha, 4 Steve Borthwick (capt), 3 Matt Stevens, 2 Schalk Brits, 1 Rhys Gill.
Replacements: 16 Jamie George, 17 John Smit, 18 Carlos Nieto, 19 Hugh Vyvyan, 20 George Kruis, 21 Richard Wigglesworth, 22 Adam Powell, 23 James Short.
|Click here for more betting|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Saracens vs Worcester|
|15:00||Exeter vs Harlequins|
|15:00||Gloucester vs London Irish|
|15:00||Sale vs Leicester|
|15:00||Wasps vs Newcastle|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Leicester vs Saracens|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
Read the thoughts and opinions of Stuart Barnes with skysports.com