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There will be a repeat of the 2011 Aviva Premiership final on Saturday when Leicester and Saracens clash for a place in this season's Twickenham showpiece.
Leicester have not enjoyed the best of times against Saracens in recent years - with Mark McCall's men having won three in a row at Welford Road, including a six-try rout earlier in the season, as well as the final last year.
However the Tigers will be buoyed by the return of Ben Youngs, George Skivington and Graham Kitchener to the squad, while George Chuter will make his 200th starting appearance for the club.
Saracens welcome back Charlie Hodgson, Will Fraser and Matt Stevens to their line-up.
Hodgson's inclusion means Owen Farrell starts in the centres, Chris Wyles moves to the wing and James Short drops to the bench.
"It's a massive match," said McCall.
"We've had a very good week of preparation but we know it is going to be a very tough game and we will have to be at our best to get the result we want.
"Leicester have a phenomenal semi-final record but we have had some excellent performances in recent weeks with wins against London Irish, Newcastle Falcons and Exeter Chiefs so we are really looking forward to the match."
Leicester: 15 Geordan Murphy (capt), 14 Horacio Agulla, 13 Manusamoa Tuilagi, 12 Anthony Allen, 11 Alesana Tuilagi, 10 Toby Flood, 9 Ben Youngs, 8 Thomas Waldrom, 7 Julian Salvi, 6 Steve Mafi, 5 Geoff Parling, 4 George Skivington, 3 Dan Cole, 2 George Chuter, 1 Marcos Ayerza.
Replacements: 16 Tom Youngs, 17 Logovi'i Mulipola, 18 Martin Castrogiovanni, 19 Graham Kitchener, 20 Craig Newby, 21 Sam Harrison, 22 Billy Twelvetrees, 23 Scott Hamilton.
Saracens: 15 Alex Goode, 14 David Strettle, 13 Owen Farrell, 12 Brad Barritt, 11 Chris Wyles, 10 Charlie Hodgson, 9 Neil de Kock, 8 Ernst Joubert, 7 Will Fraser, 6 Jackson Wray, 5 Mouritz Botha, 4 Steve Borthwick (capt), 3 Matt Stevens, 2 Schalk Brits, 1 Rhys Gill.
Replacements: 16 Jamie George, 17 John Smit, 18 Carlos Nieto, 19 Hugh Vyvyan, 20 George Kruis, 21 Richard Wigglesworth, 22 Adam Powell, 23 James Short.
|Click here for more betting|
|Saturday 25th May|
|15:00||Leicester vs Northampton|
|Sunday 12th May|
|Saracens 13 - 27 Northampton|
|Saturday 11th May|
|Leicester 33 - 16 Harlequins|
|Saturday 4th May|
|Leicester 32 - 20 London Irish|
|London Welsh 33 - 22 Worcester|
|Harlequins 22 - 19 Northampton|
|Sale 21 - 20 Wasps|
|Exeter 40 - 39 Gloucester|
|Saracens 23 - 14 Bath|
|Sunday 21st April|
|Wasps 24 - 37 Exeter|
|Saturday 20th April|
|Northampton 47 - 7 Sale|
|Gloucester 28 - 23 Saracens|
|London Irish 47 - 28 London Welsh|
|Worcester 26 - 42 Harlequins|
|Bath 27 - 26 Leicester|
|Sunday 14th April|
|Leicester 35 - 16 Wasps|
|Saracens 47 - 17 Worcester|
|London Welsh 14 - 31 Northampton|
|Saturday 13th April|
|Exeter 27 - 6 London Irish|
|Harlequins 23 - 9 Bath|
|Friday 12th April|
|Sale 32 - 9 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com