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England winger Chris Ashton will make his Saracens debut in the London Double Header against London Irish at Twickenham.
Ashton, who made the summer switch from Northampton, is the only new face in the line-up after Alistair Hargreaves picked up an injury in the build-up to the match.
Owen Farrell also suffered a knock in training, so Charlie Hodgson starts at fly-half with Joel Tomkins teaming up with Brad Barritt in the centres.
Mako Vunipola and Petrus du Plessis join Schalk Brits in the front-row, while there is a welcome return to action for Kelly Brown following a lengthy spell out.
"It promises to be an exciting season in the Aviva Premiership and looking around the league, all clubs have strengthened going into the new campaign with quality players joining from all across the globe - proving that this competition is one of the best in the world," said director of rugby Mark McCall.
"The players have worked hard over the summer months in an excellent pre-season that has allowed us to spend time together on and off the field, creating an even stronger bond among the group.
"The objective of the club is to be consistently successful and we are aware that in order for that to be achieved, there will be no substitute for hard work over the coming months - starting at Twickenham on Saturday.
"London Irish have made a number of changes on and off the field. In Brian Smith they have an experienced director of rugby and with the likes of Tomas O'Leary and Shane Geraghty joining their squad, they have also added quality on the pitch which should make for an exciting game."
New Zealand lock Bryn Evans has been handed the London Irish captaincy as Declan Danaher starts the match on the bench.
Evans will partner new signing George Skivington in the second row, with Scott Lawson and Tomas O'Leary also making their debuts.
There is also a start for Jon Fisher, who returns to the club after a season at Bedford, while fellow summer arrivals Halani Aulika, Cai Griffiths and Shane Geraghty named on the bench.
"We've got a fantastic squad on board for the 2012/13 season and we are looking forward to the season ahead," said Smith.
"This squad is very ambitious and we aim to emulate the deeds of our courageous sevens team that won the JP Morgan sevens title over the summer."
Saracens:15 Alex Goode, 14 Chris Ashton, 13 Joel Tomkins, 12 Brad Barritt, 11 Chris Wyles, 10 Charlie Hodgson, 9 Richard Wigglesworth, 8 Ernst Joubert, 7 Will Fraser, 6 Kelly Brown, 5 Mouritz Botha, 4 Steve Borthwick (c), 3 Petrus du Plessis, 2 Schalk Brits, 1 Mako Vunipola.
Replacements: 16 Jamie George, 17 Rhys Gill, 18 Carlos Nieto, 19 Eoin Sheriff, 20 Jackson Wray, 21 Neil de Kock, 22 Nils Mordt, 23 James Short.
London Irish:15 Tom Homer, 14 Topsy Ojo, 13 Jonathan Joseph, 12 Sailosi Tagicakibau, 11 Marland Yarde 10 Steve Shingler, 9 Tomás O'Leary, 8 Jon Fisher 7 Ofisa Treviranus, 6 Jamie Gibson, 5 Bryn Evans (c), 4 George Skivington, 3 Leo Halavatau, 2 Scott Lawson, 1 Max Lahiff.
Replacements: 16 Brian Blaney, 17 Halani Aulika, 18 Cai Griffiths, 19 Kieran Low, 20 Declan Danaher, 21 Alex Gray, 22 Shane Geraghty, 23 Jack Moates.
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|Friday 2nd May|
|19:45||Bath vs Northampton|
|Saturday 3rd May|
|15:00||Saracens vs Worcester|
|15:00||Wasps vs Newcastle|
|15:00||Gloucester vs London Irish|
|15:15||Sale vs Leicester|
|Sunday 4th May|
|14:00||Exeter vs Harlequins|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Leicester vs Saracens|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 20th April|
|Newcastle 18 - 23 Saracens|
|Northampton 36 - 21 London Irish|
|Saturday 19th April|
|Wasps 38 - 30 Gloucester|
|Bath 32 - 20 Worcester|
|Exeter 12 - 55 Sale|
|Friday 18th April|
|Harlequins 24 - 20 Leicester|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
Read the thoughts and opinions of Stuart Barnes with skysports.com