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Scotland international Nikki Walker will make his debut for Worcester in their Aviva Premiership clash with Gloucester at Sixways on Saturday.
After signing in the summer and missing the opening weeks of the season through injury, the 30-year-old has now been declared fully fit and goes straight into the starting line-up.
Worcester make two further changes following the defeat to Leicester last time out, with Joe Carlisle coming in at inside centre and Matt Kvesic selected at No. 8.
"Nikki had a very strong pre-season with us until he injured his shoulder, a blow which was hard for him to take after missing a lot of rugby over the last 12 months," head coach Richard Hill said.
"However, he has returned to training and made a big impression. I'm excited to see him get his full debut for Warriors.
"We also bring Joe Carlisle into inside centre, where he has operated so well off the bench this season, and Matt Kvesic at No. 8, after his showing as a replacement against Tigers. I know both will be keen to grasp the big opportunity given to them.
"I've got absolutely no doubt that with the squad of players we've assembled and the way they're training and trying to play, we will get better and better throughout the course of this season.
"However, for the coaches, players, supporters and owners, a win would be huge in the derby. We are all excited about the game and playing in front of a superb atmosphere inside Sixways."
Gloucester director of rugby Nigel Davies makes only one change to his match-day squad, with Shane Monahan replacing the injured Charlie Sharples on the right wing.
There is plenty of rotation within the 22, however, as Billy Twelvetrees moves to fly-half and Mike Tindall is promoted from the bench to inside centre.
Front-row duo Rupert Harden and Huia Edmonds also move from the bench to the starting line-up, swapping places with Darren Dawidiuk and Shaun Knight respectively.
Davies knows that his side will have a fight on their hands at Sixways despite his side's opponents having started their season with two defeats.
"We're still a team that is evolving," he said.
"We've got a lot work to do and we know that it's going to be a real dog fight. What I can assure everybody is that we'll hang in there and be in that fight.
"There are elements of the game that we have to focus on and we know that, if we get those right, then we'll be in control of the game. If we don't, they will.
"We know exactly where we are, we know exactly what we have to do and we know how tough a game this is going to be."
Worcester: 15 Chris Pennell, 14 Nikki Walker, 13 Alex Grove, 12 Joe Carlisle, 11 David Lemi, 10 Andy Goode, 9 Shaun Perry, 8 Matt Kvesic, 7 Sam Betty, 6 Chris Jones, 5 Dean Schofield (c), 4 James Percival, 3 John Andress, 2 Aleki Lutui, 1 Matt Mullan.
Replacements: 16 Ollie Hayes, 17 Ceri Jones, 18 James Currie, 19 Craig Gillies, 20 Semisi Taulava, 21 Jonny Arr, 22 Josh Matavesi, 23 Josh Drauniniu.
Gloucester: 15 Jonny May, 14 Shane Monahan, 13 Henry Trinder, 12 Mike Tindall, 11 James Simpson-Daniel, 10 Billy Twelvetrees, 9 Dan Robson, 8 Ben Morgan 7 Andy Hazell, 6 Tom Savage, 5 Jim Hamilton (c), 4 Will James, 3 Rupert Harden, 2 Huia Edmonds, 1 Nick Wood.
Replacements: 16 Darren Dawidiuk, 17 Dan Murphy, 18 Shaun Knight, 19 Sione Kalamafoni, 20 Akapusi Qera, 21 Dave Lewis, 22 Freddie Burns, 23 Rob Cook.
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|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Wasps vs Newcastle|
|15:00||Exeter vs Harlequins|
|15:00||Sale vs Leicester|
|15:00||Saracens vs Worcester|
|15:00||Gloucester vs London Irish|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Harlequins vs Bath|
|15:15||Leicester vs Saracens|
|15:15||Worcester vs Gloucester|
|15:15||Northampton vs Wasps|
|15:15||London Irish vs Sale|
|Saturday 19th April|
|Wasps 38 - 30 Gloucester|
|Bath 32 - 20 Worcester|
|Exeter 12 - 55 Sale|
|Friday 18th April|
|Harlequins 24 - 20 Leicester|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
Read the thoughts and opinions of Stuart Barnes with skysports.com