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Stephen Jones will make his competitive debut for London Wasps this weekend, having been named in the No.10 jersey to take on London Irish.
There are five changes in all to the starting line-up for Wasps, following two narrow defeats. The side have now slipped to five successive defeats in Aviva Premiership action since their 26- 24 victory over Gloucester on April 1.
Jones will direct a backline with one other change in it, with Andrea Masi coming in as a direct replacement for Chris Bell who suffered a deep cut to the head last time out.
There are three changes up front with Ashley Johnson, T Rhys Thomas and Joe Launchbury all starting.
Wasps director of rugby Dai Young said: "London Irish present a potent attacking threat and we will need to step it up in defence to try and keep them out.
"Like us, they are a new looking squad, still finding their feet but home games are vital in this league and we want to get off to a winning start at Adams Park."
Meanwhile, opposite number Brian Smith has named an unchanged London Irish side for the clash at Adams Park.
His side have also tripped up twice in the opening two rounds, conceding 40 points on both occasions.
Declan Danaher will captain the side for the second time this season.
Smith added: "Wasps have a strong squad and will be excited to be back at home. There was a big improvement from our first game last weekend and we will be looking for the same level of improvement tomorrow afternoon."
London Irish have won just once before at Adams Park, triumphing 56-37 back on April 30 in 2006.
Wasps: 15 Hugo Southwell (c), 14 Tom Varndell, 13 Elliot Daly, 12 Andrea Masi, 11 Christian Wade, 10 Stephen Jones, 9 Joe Simpson, 8 Ashley Johnson, 7 Jonathan Poff, 6 Joe Launchbury, 5 Marco Wentzel, 4 Tom Palmer, 3 Fabio Staibano, 2 T Rhys Thomas, 1 Tim Payne.
Replacements:16 Tom Lindsay, 17 Simon McIntyre, 18 Zak Taulafo, 19 James Haskell, 20 Billy Vunipola, 21 Charlie Davies, 22 Nick Robinson, 23 Tommy Bell.
London Irish: 15 Tom Homer, 14 Topsy Ojo, 13 Jonathan Joseph, 12 Sailosi Tagicakibau, 11 Marland Yarde, 10 Steve Shingler, 9 Tomás O'Leary, 8 Jon Fisher, 7 Ofisa Treviranus, 6 Declan Danaher (c), 5 Bryn Evans, 4 George Skivington, 3 Leo Halavatau, 2 Scott Lawson, 1 Max Lahiff.
Replacements: 16 Brian Blaney, 17 Halani Aulika, 18 John Ryan, 19 Kieran Low, 20 Alex Gray, 21 Anthony Watson, 22 Shane Geraghty, 23 Jack Moates.
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|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com