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Harlequins will look to maintain their perfect start to the new Aviva Premiership season when they host struggling Sale on Saturday.
Quins have so far picked up two bonus-point wins over Wasps and London Welsh to start the defence of their domestic title in fine style.
Conor O'Shea has made three changes to his starting line-up to face the Sharks, including recalling England international Danny Care at scrum-half.
The other two alterations come in the pack - Charlie Matthews joins George Robson in the second row and Nick Easter returns to start at number eight as Tom Guest moves to blindside flanker.
Peter Browne and Rory Clegg will look to make their first appearances of the season from the bench, with Maurie Fa'asavalu covering the back-row.
Quins have an excellent recent record against the Sharks and have not lost to their next opponents at home since May 2008.
Sale, like the hosts, hace made three changes to their squad from last Saturday's loss to Saracens.
Tom Brady comes in for his first game of the season - replacing the injured Will Addison - whilst Mark Easter and Mark Jennings are named on the bench.
"No-one underestimates Harlequins after their first game this season against London Wasps, when you look at the belief they had to be so many points down and come back to win," said Sharks director of rugby Bryan Redpath.
"After winning the Aviva Premiership last season, they merit every credit.
"It's a tough challenge for us on Saturday. After our performance against Saracens, we must build again, showing confidence in our attacking play as much as we have in our defence. We look forward to the game."
Sale's only away win in league action since last December came at Gloucester on April 21. As well as losing to Sarries last week they were thrashed 43-6 by Exeter Chiefs at Sandy Park on opening weekend.
Harlequins: 15 Mike Brown, 14 Tom Williams, 13 George Lowe, 12 Jordan Turner-Hall, 11 Ugo Monye, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw (c), 6 Tom Guest, 5 George Robson, 4 Charlie Matthews, 3 James Johnston, 2 Joe Gray, 1 Joe Marler.
Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Will Collier, 19 Peter Browne, 20 Maurie Fa'asavalu, 21 Karl Dickson, 22 Rory Clegg, 23 Matt Hopper.
Sale: 15 Rob Miller, 14 Tom Brady, 13 Johnny Leota, 12 Sam Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Dwayne Peel, 8 Richie Vernon, 7 David Seymour (c), 6 James Gaskell,5 Kearnan Myall, 4 Richie Gray, 3 Vadim Cobilas, 2 Joe Ward, 1 Eifion Lewis-Roberts.
Replacements: 16 Tommy Taylor, 17 Alasdair Dickinson, 18 Henry Thomas, 19 Fraser McKenzie, 20 Mark Easter, 21 Will Cliff, 22 Nick Macleod, 23 Mark Jennings.
|Click here for more betting|
|Friday 20th December|
|19:45||Sale vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:15||Saracens vs Leicester|
|Sunday 22nd December|
|14:00||Gloucester vs Worcester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|Sunday 5th January|
|14:00||Leicester vs Bath|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Exeter vs Northampton|
|15:00||Bath vs Newcastle|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
Read the thoughts and opinions of Stuart Barnes with skysports.com