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Leicester Tigers will be hoping to stop the Harlequins juggernaut in Aviva Premiership action at Welford Road on Saturday.
Quins have a 100 per cent record from their top-flight games this season while the Tigers have 12 points from three outings.
The Tigers have not lost in the regular Premiership season since February, a 19-11 defeat to Exeter - although Quins did pip them to the Premiership title at Twickenham.
Jordan Crane will captain Leicester Tigers on the return to Welford Road for the visit of the champions.
The No.8 runs out at the head of the team in the absence of Geordan Murphy, who suffered a knee injury in the draw against Saracens at Wembley last weekend.
Scott Hamilton reverts to full-back in place of Murphy, with Niall Morris coming into the backline. Matt Smith is also included.
Boris Stankovich and Martin Castrogiovanni are in the front row alongside hooker Tom Youngs.
Adam Thompstone, a summer signing from London Irish, could make his Tigers debut after being included among the replacements.
Harlequins have made just the one change to their squad for the trip to Leicester.
Matt Hopper starts at outside centre, replacing George Lowe who took a knock during training this week.
In the forwards, Olly Kohn returns to partner George Robson in the second-row while Maurie Fa'asavalu joins Nick Easter and captain, Chris Robshaw in the back-row.
Leicester: 15 Scott Hamilton, 14 Niall Morris, 13 Matt Smith, 12 Anthony Allen, 11 Vereniki Goneva, 10 Toby Flood, 9 Sam Harrison, 8 Jordan Crane (c), 7 Julian Salvi, 6 Steve Mafi, 5 Geoff Parling, 4 Graham Kitchener, 3 Martin Castrogiovanni, 2 Tom Youngs, 1 Boris Stankovich.
Replacements: 16 George Chuter, 17 Dan Cole, 18 Logovi'i Mulipola, 19 Rob Andrew, 20 Thomas Waldrom, 21 Patrick Phibbs, 22 George Ford, 23 Adam Thompstone.
Harlequins: 15 Mike Brown, 14 Tom Williams, 13 Matt Hopper, 12 Jordan Turner Hall, 11 Ugo Monye, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw (c), 6 Maurie Fa'asavalu, 5 George Robson, 4 Olly Kohn, 3 James Johnston, 2 Joe Gray, 1 Joe Marler.
Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Will Collier, 19 Charlie Matthews, 20 Tom Guest, 21 Karl Dickson, 22 Rory Clegg, 23 Ross Chisholm.
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|Saturday 25th May|
|15:00||Leicester vs Northampton|
|Sunday 12th May|
|Saracens 13 - 27 Northampton|
|Saturday 11th May|
|Leicester 33 - 16 Harlequins|
|Saturday 4th May|
|Leicester 32 - 20 London Irish|
|London Welsh 33 - 22 Worcester|
|Harlequins 22 - 19 Northampton|
|Exeter 40 - 39 Gloucester|
|Saracens 23 - 14 Bath|
|Sale 21 - 20 Wasps|
|Sunday 21st April|
|Wasps 24 - 37 Exeter|
|Saturday 20th April|
|Northampton 47 - 7 Sale|
|Gloucester 28 - 23 Saracens|
|London Irish 47 - 28 London Welsh|
|Worcester 26 - 42 Harlequins|
|Bath 27 - 26 Leicester|
|Sunday 14th April|
|Leicester 35 - 16 Wasps|
|Saracens 47 - 17 Worcester|
|London Welsh 14 - 31 Northampton|
|Saturday 13th April|
|Exeter 27 - 6 London Irish|
|Harlequins 23 - 9 Bath|
|Friday 12th April|
|Sale 32 - 9 Gloucester|
|Sunday 31st March|
|London Irish 33 - 33 Sale|
|Saturday 30th March|
|Worcester 18 - 24 Exeter|
|Northampton 8 - 36 Leicester|
|Wasps 13 - 22 Saracens|
|Bath 40 - 25 London Welsh|
Read the thoughts and opinions of Stuart Barnes with skysports.com