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Leicester Tigers will be hoping to stop the Harlequins juggernaut in Aviva Premiership action at Welford Road on Saturday.
Quins have a 100 per cent record from their top-flight games this season while the Tigers have 12 points from three outings.
The Tigers have not lost in the regular Premiership season since February, a 19-11 defeat to Exeter - although Quins did pip them to the Premiership title at Twickenham.
Jordan Crane will captain Leicester Tigers on the return to Welford Road for the visit of the champions.
The No.8 runs out at the head of the team in the absence of Geordan Murphy, who suffered a knee injury in the draw against Saracens at Wembley last weekend.
Scott Hamilton reverts to full-back in place of Murphy, with Niall Morris coming into the backline. Matt Smith is also included.
Boris Stankovich and Martin Castrogiovanni are in the front row alongside hooker Tom Youngs.
Adam Thompstone, a summer signing from London Irish, could make his Tigers debut after being included among the replacements.
Harlequins have made just the one change to their squad for the trip to Leicester.
Matt Hopper starts at outside centre, replacing George Lowe who took a knock during training this week.
In the forwards, Olly Kohn returns to partner George Robson in the second-row while Maurie Fa'asavalu joins Nick Easter and captain, Chris Robshaw in the back-row.
Leicester: 15 Scott Hamilton, 14 Niall Morris, 13 Matt Smith, 12 Anthony Allen, 11 Vereniki Goneva, 10 Toby Flood, 9 Sam Harrison, 8 Jordan Crane (c), 7 Julian Salvi, 6 Steve Mafi, 5 Geoff Parling, 4 Graham Kitchener, 3 Martin Castrogiovanni, 2 Tom Youngs, 1 Boris Stankovich.
Replacements: 16 George Chuter, 17 Dan Cole, 18 Logovi'i Mulipola, 19 Rob Andrew, 20 Thomas Waldrom, 21 Patrick Phibbs, 22 George Ford, 23 Adam Thompstone.
Harlequins: 15 Mike Brown, 14 Tom Williams, 13 Matt Hopper, 12 Jordan Turner Hall, 11 Ugo Monye, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw (c), 6 Maurie Fa'asavalu, 5 George Robson, 4 Olly Kohn, 3 James Johnston, 2 Joe Gray, 1 Joe Marler.
Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Will Collier, 19 Charlie Matthews, 20 Tom Guest, 21 Karl Dickson, 22 Rory Clegg, 23 Ross Chisholm.
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|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com