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Full-back Rob Cook and back-rower Sione Kalamafoni will make their first starts for Gloucester when they welcome Wasps to Kingsholm on Saturday afternoon.
Cook and Kalamafoni have both made cameo appearances from the bench this season, but are called into the starting line-up as two of seven changes director of rugby Nigel Davies has made to the side that started at Worcester last weekend.
Lincoln-born Cook is handed the No.15 jersey with Jonny May moving to the right wing in the absence of injured duo Charlie Sharples and Shane Monahan.
Freddie Burns returns at fly-half and, to accommodate him, Billy Twelvetrees moves across to inside centre.
Darren Dawidiuk will start at hooker and Tom Savage moves into the second row from the blind side flank with Tongan international Kalamafoni taking over the number six shirt.
Speaking ahead of the match, Gloucester chief Davies is hoping to take the momentum gathered from a win and a draw in the last two fixtures into the televised clash.
He said: "We've learned a lot about ourselves, we've been able to progress and have had three competitive fixtures now. That's where you really test yourselves.
"We've learned a lot. I believe we've got a clear understanding of where our game needs to be and what it's about and, if we can get anywhere near it, then we're going to play a good brand of rugby come Saturday."
Wasps director of rugby Dai Young has made three changes to his starting XV for Saturday's trip to the West Country.
Tommy Bell gets his first start at full-back in place of skipper Hugo Southwell, who misses out with a hand injury. James Haskell replaces Joe Launchbury, who is also out with injury, while Zak Taulafo starts after this try-scoring impact from the bench against London Irish last weekend.
Marco Wentzel captains the side this weekend as Wasps go in search of a first win on the road this season following a bonus point victory over the Exiles at Adams Park last weekend.
Despite scoring four tries in their win over London Irish last week Young wants an improved showing from his side.
"We are looking for a consistent 80 minute performance, which we haven't put together yet in any of our three games," he said.
"We have a chance of going down there and winning if we do that well, and if we don't they are a physical side with backs who can really punish you."
Gloucester: 15 Rob Cook, 14 Jonny May, 13 Henry Trinder, 12 Billy Twelvetrees, 11 James Simpson-Daniel, 10 Freddie Burns, 9 Dan Robson, 8 Ben Morgan. 7 Andy Hazell, 6 Sione Kalamafoni, 5 Jim Hamilton (c), 4 Tom Savage, 3 Rupert Harden, 2 Darren Dawidiuk, 1 Nick Wood.
Replacements: 16 Huia Edmonds, 17 Dan Murphy, 18 Shaun Knight, 19 Will James, 20 Akapusi Qera, 21 Dave Lewis, 22 Mike Tindall, 23 Martyn Thomas.
London Wasps: 15 Tommy Bell, 14 Tom Varndell, 13 Elliot Daly, 12 Andrea Masi, 11 Christian Wade, 10 Stephen Jones, 9 Joe Simpson, 8 Ashley Johnson, 7 Jonathan Poff, 6 James Haskell, 5 Marco Wentzel (c), 4 Tom Palmer, 3 Zak Taulafo, 2 T Rhys Thomas, 1 Tim Payne.
Replacements: 16 Tom Lindsay, 17 Simon McIntyre, 18 Fabio Staibano, 19 James Cannon, 20 Billy Vunipola, 21 Charlie Davies, 22 Nick Robinson, 23 Jack Wallace.
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|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com