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Leicester Tigers welcome back Geordan Murphy, Ben Youngs and Julian Salvi for Saturday's Premiership derby against Northampton Saints.
Skipper Murphy has recovered from a knee injury, while Youngs has been released from the England squad after missing last week's match at Gloucester.
Salvi returns to the back row and is joined by Steve Mafi and summer signing Richard Thorpe.
There are calls for Marcos Ayerza, George Chuter and Martin Castrogiovanni in the front row, and George Ford starts at fly-half.
Dan Bowden returns to the matchday squad and back-rower Michael Noone is included among the replacements for the first time.
Meanwhile, Northampton will be looking to bounce back from home reverse to Saracens last weekend.
Flanker Calum Clarke returns to the starting XV after completing a 32-week suspension imposed for breaking the arm of Leicester hooker Rob Hawkins in last season's LV= Cup final.
Phil Dowson, released by England, captains the side but Lee Dickson, Tom Wood, Courtney Lawes, Dylan Hartley and Stephen Myler are all absent.
Leicester Tigers: 15 Geordan Murphy (c), 14 Scott Hamilton, 13 Matt Smith, 12 Anthony Allen, 11 Niall Morris, 10 George Ford, 9 Ben Youngs, 8 Richard Thorpe, 7 Julian Salvi, 6 Steve Mafi 5 Graham Kitchener, 4 Louis Deacon, 3 Martin Castrogiovanni, 2 George Chuter, 1 Marcos Ayerza.
Replacements: 16 Jimmy Stevens, 17 Boris Stankovich, 18 Fraser Balmain, 19 Ed Slater, 20 Michael Noone, 21 Sam Harrison, 22 Dan Bowden, 23 Vereniki Goneva.
Northampton Saints: 15 Tom May 14 Ken Pisi 13 George Pisi 12 Dom Waldouck 11 Jamie Elliott 10 Ryan Lamb 9 Martin Roberts 8 GJ Van Velze 7 Phil Dowson (capt) 6 Calum Clark 5 Mark Sorenson 4 Samu Manoa 3 Brian Mujati 2 Mike Haywood 1 Soane Tonga'uiha.
Replacements: 16 Ross Mcmillan 17 Alex Waller 18 Paul Doran Jones 19 Ben Nutley 20 Rhys Oakley 21 Alex Day 22 Luther Burrell 23 Vasily Artemyev.
"We've looked at our past performances and there have been bits where we've played well and bits where we haven't. Of course we've worked on those areas and while it's going to be a massive challenge at Welford Road it's one that we're up for."
|Click here for more betting|
|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com