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London Irish face an uphill task if they are to move away from the Aviva Premiership drop zone against the Leicester Tigers at Madejski Stadium.
Irish are second from bottom in the table with two wins from 12 while the Tigers have won on three of their last four trips to Reading.
Geordan Murphy, Toby Flood, Graham Kitchener and Jordan Crane all return for Leicester.
Club captain Murphy will make his 200th Premiership appearance as he is included in the starting line-up for the first time since the win over Northampton Saints in early November.
He becomes the 19th player to reach that top-flight landmark, with club colleague George Chuter holding the all-time record with 258 appearances.
Fly-half Flood has recovered from a toe injury and makes his first club appearance since the end of October.
Kitchener comes into the second row for Tigers, and Crane takes the number eight shirt with Thomas Waldrom ruled out by a calf injury picked up in last Saturday's Heineken Cup win over Treviso in Italy.
Marland Yarde has recovered from injury and will start for Irish while Ian Humphreys starts at fly half and Jebb Sinclair joins Declan Danaher and Chris Hala'ufia in the back row.
London Irish: 15 Tom Homer, 14 Topsy Ojo, 13 Jonathan Joseph, 12 Sailosi Tagicakibau, 11 Marland Yarde, 10 Ian Humphreys, 9 Darren Allinson, 1 Max Lahiff, 2 David Paice, 3 Halani Aulika, 4 Bryn Evans, 5 Matt Garvey, 6 Declan Danaher (c), 7 Jebb Sinclair, 8 Chris Hala'ufia.
Replacements: 16 Scott Lawson, 17 Jerry Yanuyanutawa, 18 Leo Halavatau, 19 Kieran Low, 20 Jamie Gibson, 21 Guy Armitage, 22 Shane Geraghty, 23 Jack Moates.
Leicester: 15 Geordan Murphy, 14 Niall Morris, 13 Manusamoa Tuilagi, 12 Anthony Allen, 11 Adam Thompstone, 10 Toby Flood, 9 Ben Youngs, 8 Jordan Crane, 7 Julian Salvi, 6 Brett Deacon, 5 Graham Kitchener, 4 Louis Deacon (c), 3 Dan Cole, 2 Tom Youngs, 1 Marcos Ayerza.
Replacements: 16 Rob Hawkins, 17 Logovi'i Mulipola, 18 Fraser Balmain, 19 Ed Slater, 20 Geoff Parling, 21 Sam Harrison, 22 George Ford, 23 Matt Smith.
"It will be great to be playing back at the Madejski in front of our home crow.
"Leicester has been the benchmark team in the Aviva Premiership for a long time now and they'll give us a thorough examination. In saying that we don't fear any team in this league and the boys are itching to play the Tigers."
"We have come out on top of some close games down there in recent years and we have to make sure that doesn't change. They have some good open-field runners and we will have to improve from last week against a team that is better than their position in the table."
Don't miss any live and exclusive rugby union coverage this festive season. Click here to visit Sky Sports' Festive Calendar
|Click here for more betting|
|Friday 20th December|
|20:00||Sale Sharks vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:00||Saracens vs Leicester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|15:00||Leicester vs Bath|
|Sunday 5th January|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Bath vs Newcastle|
|15:00||Exeter vs Northampton|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|15:00||Leicester vs Gloucester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
|Sunday 27th October|
|Newcastle 13 - 11 London Irish|
|Wasps 22 - 12 Leicester|
|Saturday 26th October|
|Northampton 41 - 20 Saracens|
|Exeter 40 - 6 Worcester|
|Harlequins 24 - 3 Sale Sharks|
|Friday 25th October|
|Bath 15 - 13 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com