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Harlequins are gunning for a fifth straight win in all competitions on Saturday against a London Irish side who are at the wrong end of the table.
League leaders Quins are unchanged from the side which beat Northampton Saints 18-9 last weekend.
Among the replacements, Rob Buchanan comes in to provide cover at hooker, while George Lowe returns from injury and will look to make his first appearance since November 16.
Meanwhile, Irish have also announced an unchanged starting XV .
Director of rugby Brian Smith retains the starting line-up that played Leicester Tigers at Madejski Stadium last weekend.
There are three changes among the replacements where George Skivington returns from injury to cover the second row. Steven Shingler and new signing Patrick Phibbs provide half-back cover.
Harlequins: 15 Mike Brown, 14 Tom Williams, 13 Matt Hopper, 12 Tom Casson, 11 Ugo Monye, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw (c), 6 Maurie Fa'asavalu, 5 George Robson, 4 Olly Kohn, 3 James Johnston, 2 Joe Gray, 1 Joe Marler.
Replacements: 16 Rob Buchanan, 17 Mark Lambert, 18 Will Collier, 19 Charlie Matthews, 20 Tom Guest, 21 Karl Dickson, 22 Ben Botica, 23 George Lowe.
London Irish: 15 Tom Homer, 14 Topsy Ojo, 13 Jonathan Joseph, 12 Sailosi Tagicakibau, 11 Marland Yarde, 10 Ian Humphreys, 9 Darren Allinson ,8 Chris Hala'ufia, 7 Jebb Sinclair, 6 Declan Danaher (c), 5 Matt Garvey, 4 Bryn Evans, 3 Halani Aulika, 2 David Paice, 1 Max Lahiff.
Replacements: 16 Scott Lawson, 17 Jerry Yanuyanutawa, 18 Leo Halavatau, 19 George Skivington, 20 Jamie Gibson, 21 Guy Armitage, 22 Steven Shingler, 23 Pat Phibbs.
"We feel like we owe them [Harlequins] one," Paice told the Reading Chronicle.
"They won't intimidate us, they are a very good team but we should have beaten them at home and we have the belief we can beat them again.
"Playing at Twickenham it's almost like a final, a one-off game, we were happy with how we performed against them at our home ground and we are playing well."
|Click here for more betting|
|Saturday 25th May|
|15:00||Leicester vs Northampton|
|Sunday 12th May|
|Saracens 13 - 27 Northampton|
|Saturday 11th May|
|Leicester 33 - 16 Harlequins|
|Saturday 4th May|
|Leicester 32 - 20 London Irish|
|London Welsh 33 - 22 Worcester|
|Harlequins 22 - 19 Northampton|
|Sale 21 - 20 Wasps|
|Exeter 40 - 39 Gloucester|
|Saracens 23 - 14 Bath|
|Sunday 21st April|
|Wasps 24 - 37 Exeter|
|Saturday 20th April|
|Northampton 47 - 7 Sale|
|Gloucester 28 - 23 Saracens|
|London Irish 47 - 28 London Welsh|
|Worcester 26 - 42 Harlequins|
|Bath 27 - 26 Leicester|
|Sunday 14th April|
|Leicester 35 - 16 Wasps|
|Saracens 47 - 17 Worcester|
|London Welsh 14 - 31 Northampton|
|Saturday 13th April|
|Exeter 27 - 6 London Irish|
|Harlequins 23 - 9 Bath|
|Friday 12th April|
|Sale 32 - 9 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com