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Harlequins have recalled a number of first-choice players for their Aviva Premiership clash with Wasps at Twickenham Stoop on Saturday.
Joe Gray, George Robson, Ugo Monye, George Lowe, Jordan Turner-Hall and Rob Buchanan all return to the side following international duty with the England Saxons
After missing the recent LV= Cup double-header, winger Tom Williams, fly-half Nick Evans and captain Nick Easter all return for the league clash.
The defending champions currently sit two points clear at the top of the table and are on a 12-match winning streak in all competitions going back to November.
Wasps have named Billy Vunipola in the starting line-up at No 8 after he was released back from the England squad.
The visitors have also made a host of changes following their LV= Cup defeat to Sale, with their ranks boosted by England Saxons returnees.
Joe Simpson and Nick Robinson are named in the halves, while the back-three of Tom Varndell, Christian Wade and skipper Hugo Southwell is re-united.
They were also forced into a late change on the bench with Matt Everard taking over from Tinus DuPlessis.
Harlequins: 15 Ross Chisholm, 14 Tom Williams, 13 George Lowe, 12 Matt Hopper, 11 Ugo Monye, 10 Nick Evans, 9 Karl Dickson, 8 Nick Easter (c), 7 Luke Wallace, 6 Tom Guest, 5 George Robson, 4 Charlie Matthews, 3 James Johnston, 2 Joe Gray, 1 Mark Lambert.
Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Will Collier, 19 Sam Twomey, 20 Maurie Fa'asavalu, 21 Ollie Lindsay-Hague, 22 Rory Clegg, 23 Jordan Turner-Hall.
Wasps: 15 Hugo Southwell (c), 14 Christian Wade, 13 Elliot Daly, 12 Chris Bell, 11 Tom Varndell, 10 Nick Robinson, 9 Joe Simpson, 8 Billy Vunipola, 7 Sam Jones, 6 Ashley Johnson, 5 Marco Wentzel, 4 James Cannon, 3 Phil Swainston, 2 T Rhys Thomas, 1 Zak Taulafo.
Replacements: 16 Tom Lindsay, 17 Tim Payne, 18 Will Taylor, 19 Alex Rae, 20 Matt Everard, 21 Charlie Davies, 22 Stephen Jones, 23 Charlie Hayter.
"There has been a good atmosphere around the place this week in leading up to the first Aviva Premiership game in over a month.
"Harlequins are a side who tend to negotiate the international periods very well so we know how tough a task we will have on Saturday night.
"They showed us how quickly they can change a game on the opening day of the season and we will have to be at our best to get a result this weekend."
|Click here for more betting|
|Saturday 25th May|
|15:00||Leicester vs Northampton|
|Sunday 12th May|
|Saracens 13 - 27 Northampton|
|Saturday 11th May|
|Leicester 33 - 16 Harlequins|
|Saturday 4th May|
|Leicester 32 - 20 London Irish|
|London Welsh 33 - 22 Worcester|
|Harlequins 22 - 19 Northampton|
|Sale 21 - 20 Wasps|
|Exeter 40 - 39 Gloucester|
|Saracens 23 - 14 Bath|
|Sunday 21st April|
|Wasps 24 - 37 Exeter|
|Saturday 20th April|
|Northampton 47 - 7 Sale|
|Gloucester 28 - 23 Saracens|
|London Irish 47 - 28 London Welsh|
|Worcester 26 - 42 Harlequins|
|Bath 27 - 26 Leicester|
|Sunday 14th April|
|Leicester 35 - 16 Wasps|
|Saracens 47 - 17 Worcester|
|London Welsh 14 - 31 Northampton|
|Saturday 13th April|
|Exeter 27 - 6 London Irish|
|Harlequins 23 - 9 Bath|
|Friday 12th April|
|Sale 32 - 9 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com