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Gloucester enter Saturday's clash with London Welsh chasing a top-four spot, while the visitors remain rooted at the foot of the table.
The Exiles enter the clash at Kingsholm bottom of the table after being handed a five-point deduction for fielding an ineligible player earlier in the season.
Recent form for London Welsh has been poor with seven successive defeats in all competitions.
Hosts Gloucester have lost two of their last four Aviva Premiership encounters and will look to get back to winning ways as they seek a play-off spot.
Gloucester coach Nigel Davies makes a number of changes to his side as players return from international duty.
Scotland's Jim Hamilton comes straight back into the side as captain following the Six Nations finale, while Billy Twelvetrees starts after featuring in England's campaign.
In a new look pack, Davies names Huia Edmonds and Shaun Knight in the front row while Andy Hazell and Peter Buxton get the nod on the flanks.
Meanwhile the visitors make five changes ahead of the Kingsholm clash with Seb Jewell, Gonzalo Tiesi, Dan George and Daniel Browne all making the starting XV.
Jewell replaces the injured Tom Arscott at inside centre while Tiesi returns to the number 13 jersey after an injury lay-off.
London Welsh coach Lyn Jones has opted for George in the front row with Greg Bateman demoted to the bench, while Browne starts at number eight against his former club with Alfie To'oala missing out.
Gloucester: 15 Rob Cook, 14 Charlie Sharples, 13 Mike Tindall, 12 Billy Twelvetrees, 11 Jonny May, 10 Freddie Burns, 9 Dan Robson, 8 Sione Kalamafoni, 7 Andy Hazell, 6 Peter Buxton, 5 Will James, 4 Jim Hamilton (capt), 3 Shaun Knight, 2 Huia Edmonds, 1 Nick Wood.
Replacements: 16 Koree Britton, 17 Yann Thomas, 18 Dario Chistolini, 19 Tom Savage, 20 Akapusi Qera, 21 Dave Lewis, 22 Henry Trinder, 23 Martyn Thomas.
London Welsh: 15 Seb Jewell, 14 Phil MacKenzie, 13 Gonzalo Tiesi, 12 Sonny Parker, 11 Seb Stegmann, 10 Gavin Henson, 9 Tyson Keats, 8 Daniel Browne, 7 Michael Hills, 6 Julio Cabello Farias, 5 Kirill Kulemin, 4 Jonathan Mills (capt), 3 James Tideswell, 2 Greg Dan George, 1 Tom Bristow.
Replacements: 16 Greg Bateman, 17 Billy Moss, 18 Arthur Joly, 19 Matt Corker, 20 Adam Balding, 21 Alex Davies, 22 Gordon Ross, 23 Nick Scott.
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|Saturday 25th May|
|15:00||Leicester vs Northampton|
|Sunday 12th May|
|Saracens 13 - 27 Northampton|
|Saturday 11th May|
|Leicester 33 - 16 Harlequins|
|Saturday 4th May|
|Leicester 32 - 20 London Irish|
|London Welsh 33 - 22 Worcester|
|Harlequins 22 - 19 Northampton|
|Sale 21 - 20 Wasps|
|Exeter 40 - 39 Gloucester|
|Saracens 23 - 14 Bath|
|Sunday 21st April|
|Wasps 24 - 37 Exeter|
|Saturday 20th April|
|Northampton 47 - 7 Sale|
|Gloucester 28 - 23 Saracens|
|London Irish 47 - 28 London Welsh|
|Worcester 26 - 42 Harlequins|
|Bath 27 - 26 Leicester|
|Sunday 14th April|
|Leicester 35 - 16 Wasps|
|Saracens 47 - 17 Worcester|
|London Welsh 14 - 31 Northampton|
|Saturday 13th April|
|Exeter 27 - 6 London Irish|
|Harlequins 23 - 9 Bath|
|Friday 12th April|
|Sale 32 - 9 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com