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Gloucester enter Saturday's clash with London Welsh chasing a top-four spot, while the visitors remain rooted at the foot of the table.
The Exiles enter the clash at Kingsholm bottom of the table after being handed a five-point deduction for fielding an ineligible player earlier in the season.
Recent form for London Welsh has been poor with seven successive defeats in all competitions.
Hosts Gloucester have lost two of their last four Aviva Premiership encounters and will look to get back to winning ways as they seek a play-off spot.
Gloucester coach Nigel Davies makes a number of changes to his side as players return from international duty.
Scotland's Jim Hamilton comes straight back into the side as captain following the Six Nations finale, while Billy Twelvetrees starts after featuring in England's campaign.
In a new look pack, Davies names Huia Edmonds and Shaun Knight in the front row while Andy Hazell and Peter Buxton get the nod on the flanks.
Meanwhile the visitors make five changes ahead of the Kingsholm clash with Seb Jewell, Gonzalo Tiesi, Dan George and Daniel Browne all making the starting XV.
Jewell replaces the injured Tom Arscott at inside centre while Tiesi returns to the number 13 jersey after an injury lay-off.
London Welsh coach Lyn Jones has opted for George in the front row with Greg Bateman demoted to the bench, while Browne starts at number eight against his former club with Alfie To'oala missing out.
Gloucester: 15 Rob Cook, 14 Charlie Sharples, 13 Mike Tindall, 12 Billy Twelvetrees, 11 Jonny May, 10 Freddie Burns, 9 Dan Robson, 8 Sione Kalamafoni, 7 Andy Hazell, 6 Peter Buxton, 5 Will James, 4 Jim Hamilton (capt), 3 Shaun Knight, 2 Huia Edmonds, 1 Nick Wood.
Replacements: 16 Koree Britton, 17 Yann Thomas, 18 Dario Chistolini, 19 Tom Savage, 20 Akapusi Qera, 21 Dave Lewis, 22 Henry Trinder, 23 Martyn Thomas.
London Welsh: 15 Seb Jewell, 14 Phil MacKenzie, 13 Gonzalo Tiesi, 12 Sonny Parker, 11 Seb Stegmann, 10 Gavin Henson, 9 Tyson Keats, 8 Daniel Browne, 7 Michael Hills, 6 Julio Cabello Farias, 5 Kirill Kulemin, 4 Jonathan Mills (capt), 3 James Tideswell, 2 Greg Dan George, 1 Tom Bristow.
Replacements: 16 Greg Bateman, 17 Billy Moss, 18 Arthur Joly, 19 Matt Corker, 20 Adam Balding, 21 Alex Davies, 22 Gordon Ross, 23 Nick Scott.
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|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com