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Former Western Province lock Quinn Roux will make his home debut for Leinster in Saturday's PRO12 clash with the Dragons in Dublin.
Roux partners skipper Leo Cullen in the second row while another home debut is handed to Leinster Academy flanker Ben Marshall.
Marshall, who made his first appearance for the province away to Ulster in December 2010, comes into the back-row alongside Shane Jennings and number eight Leo Auva'a.
Ireland hooker Sean Cronin is included in the front row alongside Jamie Hagan and Jack McGrath, while John Cooney will link up with Ian Madigan at half-back in the absence of the injured Isaac Boss.
The rest of Leinster's largely fledgling back-line that started last weekend's game in Llanelli remains the same, aside from the experienced Isa Nacewa who will make his 104th appearance.
Devin Toner is named on the replacements bench alongside prop Heinke van der Merwe.
Meanwhile, Dragons back row Jevon Groves will lead the men of Gwent for the first time after being named as skipper.
Although this is his first outing as Dragons captain, he is no stranger to the position, having captained the Wales Sevens team to the plate semi-finals during the 2010 Commonwealth Games.
Fellow back-row and regional captain Lewis Evans makes his return from injury from the bench whilst prop Tim Ryan starts his competitive career at the Dragons as a replacement.
With an unchanged back-line from the 37-6 victory over the Zebre last week, head coach Darren Edwards has rung the changes in the forwards with Groves, Ian Nimmo and Toby Faletau the only survivors from last weekend's starting line-up.
Leinster: 15 Isa Nacewa, 14 Andrew Conway, 13 Brendan Macken, 12 Noel Reid, 11 Fionn Carr, 10 Ian Madigan, 9 John Cooney, 8 Leo Auva'a, 7 Shane Jennings, 6 Ben Marshall, 5 Quinn Roux, 4 Leo Cullen (c), 3 Jamie Hagan, 2 Sean Cronin, 1 Jack McGrath.
Replacements: 16 Tom Sexton 17 Heinke van der Merwe 18 Martin Moore 19 Devin Toner 20 Jordi Murphy 21 Luke McGrath 22 Colm O'Shea 23 Darren Hudson.
Newport Gwent Dragons: 15 Dan Evans, 14 Will Harries, 13 Pat Leach, 12 Andy Tuilagi, 11 Tom Prydie, 10 Steffan Jones, 9 Jonathan Evans, 8 Toby Faletau, 7 Jevon Groves (c), 6 Hywel Stoddart, 5 Adam Jones, 4 Ian Nimmo, 3 Nathan Buck, 2 Sam Parry, 1 Nathan Williams.
Replacements: 16 Hugh Gustafson, 17 Aaron Coundley, 18 Tim Ryan, 19 Lewis Evans, 20 Tom Brown, 21 Liam Davies (Bedwas), 22 Ashley Smith, 23 Hallam Amos.
Date: Saturday, September 8
Venue: RDS, Dublin
Kick-off: 18.15 BST (17.15 GMT)
Referee: Marius Mitrea
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|Saturday 25th May|
|16:45||Ulster vs Leinster|
|Saturday 11th May|
|Leinster 17 - 15 Glasgow|
|Friday 10th May|
|Ulster 28 - 17 Scarlets|
|Friday 3rd May|
|Edinburgh 31 - 24 Newport Gwent D'gons|
|Connacht 3 - 20 Glasgow|
|Zebre 25 - 27 Munster|
|Scarlets 17 - 41 Benetton Treviso|
|Leinster 37 - 19 Ospreys|
|Ulster 37 - 13 Cardiff Blues|
|Friday 26th April|
|Benetton Treviso 23 - 23 Connacht|
|Sunday 21st April|
|Zebre 22 - 41 Leinster|
|Saturday 20th April|
|Scarlets 24 - 6 Cardiff Blues|
|Friday 19th April|
|Connacht 18 - 34 Ulster|
|Glasgow 35 - 17 Ospreys|
|Benetton Treviso 30 - 10 Edinburgh|
|Newport Gwent D'gons 30 - 24 Munster|
|Saturday 13th April|
|Ospreys 28 - 3 Benetton Treviso|
|Munster 16 - 22 Leinster|
|Cardiff Blues 28 - 13 Zebre|
|Friday 12th April|
|Edinburgh 24 - 32 Connacht|
|Ulster 31 - 5 Newport Gwent D'gons|
|Scarlets 29 - 6 Glasgow|
Read the thoughts and opinions of Stuart Barnes with skysports.com