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Former Western Province lock Quinn Roux will make his home debut for Leinster in Saturday's PRO12 clash with the Dragons in Dublin.
Roux partners skipper Leo Cullen in the second row while another home debut is handed to Leinster Academy flanker Ben Marshall.
Marshall, who made his first appearance for the province away to Ulster in December 2010, comes into the back-row alongside Shane Jennings and number eight Leo Auva'a.
Ireland hooker Sean Cronin is included in the front row alongside Jamie Hagan and Jack McGrath, while John Cooney will link up with Ian Madigan at half-back in the absence of the injured Isaac Boss.
The rest of Leinster's largely fledgling back-line that started last weekend's game in Llanelli remains the same, aside from the experienced Isa Nacewa who will make his 104th appearance.
Devin Toner is named on the replacements bench alongside prop Heinke van der Merwe.
Meanwhile, Dragons back row Jevon Groves will lead the men of Gwent for the first time after being named as skipper.
Although this is his first outing as Dragons captain, he is no stranger to the position, having captained the Wales Sevens team to the plate semi-finals during the 2010 Commonwealth Games.
Fellow back-row and regional captain Lewis Evans makes his return from injury from the bench whilst prop Tim Ryan starts his competitive career at the Dragons as a replacement.
With an unchanged back-line from the 37-6 victory over the Zebre last week, head coach Darren Edwards has rung the changes in the forwards with Groves, Ian Nimmo and Toby Faletau the only survivors from last weekend's starting line-up.
Leinster: 15 Isa Nacewa, 14 Andrew Conway, 13 Brendan Macken, 12 Noel Reid, 11 Fionn Carr, 10 Ian Madigan, 9 John Cooney, 8 Leo Auva'a, 7 Shane Jennings, 6 Ben Marshall, 5 Quinn Roux, 4 Leo Cullen (c), 3 Jamie Hagan, 2 Sean Cronin, 1 Jack McGrath.
Replacements: 16 Tom Sexton 17 Heinke van der Merwe 18 Martin Moore 19 Devin Toner 20 Jordi Murphy 21 Luke McGrath 22 Colm O'Shea 23 Darren Hudson.
Newport Gwent Dragons: 15 Dan Evans, 14 Will Harries, 13 Pat Leach, 12 Andy Tuilagi, 11 Tom Prydie, 10 Steffan Jones, 9 Jonathan Evans, 8 Toby Faletau, 7 Jevon Groves (c), 6 Hywel Stoddart, 5 Adam Jones, 4 Ian Nimmo, 3 Nathan Buck, 2 Sam Parry, 1 Nathan Williams.
Replacements: 16 Hugh Gustafson, 17 Aaron Coundley, 18 Tim Ryan, 19 Lewis Evans, 20 Tom Brown, 21 Liam Davies (Bedwas), 22 Ashley Smith, 23 Hallam Amos.
Date: Saturday, September 8
Venue: RDS, Dublin
Kick-off: 18.15 BST (17.15 GMT)
Referee: Marius Mitrea
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|Friday 14th March|
|19:05||Ulster vs Scarlets|
|Friday 21st March|
|19:05||Ospreys vs Cardiff Blues|
|19:15||Leinster vs Zebre|
|19:45||Edinburgh vs Ulster|
|Saturday 22nd March|
|15:00||Glasgow vs Scarlets|
|19:15||Munster vs Benetton Treviso|
|Sunday 23rd March|
|15:05||Newport Gwent D'gons vs Connacht|
|Saturday 29th March|
|15:00||Zebre vs Newport Gwent D'gons|
|18:00||Benetton Treviso vs Edinburgh|
|18:30||Cardiff Blues vs Ulster|
|19:00||Leinster vs Munster|
|Sunday 30th March|
|14:05||Scarlets vs Connacht|
|Thursday 3rd April|
|18:30||Newport Gwent D'gons vs Edinburgh|
|Friday 11th April|
|19:05||Ulster vs Connacht|
|19:05||Ospreys vs Leinster|
|19:45||Edinburgh vs Cardiff Blues|
|Saturday 12th April|
|18:00||Benetton Treviso vs Newport Gwent D'gons|
|18:30||Munster vs Glasgow|
|18:30||Scarlets vs Zebre|
|Saturday 19th April|
|15:00||Zebre vs Edinburgh|
|15:00||Glasgow vs Ulster|
|15:00||Leinster vs Benetton Treviso|
|15:00||Connacht vs Munster|
|Sunday 20th April|
|14:00||Cardiff Blues vs Scarlets|
|16:45||Newport Gwent D'gons vs Ospreys|
|Saturday 1st March|
|Leinster 28 - 25 Glasgow|
|Scarlets 18 - 13 Munster|
|Connacht 38 - 6 Benetton Treviso|
|Zebre 15 - 10 Cardiff Blues|
|Friday 28th February|
|Edinburgh 31 - 25 Ospreys|
|Ulster 38 - 8 Newport Gwent D'gons|
|Sunday 23rd February|
|Zebre 19 - 27 Connacht|
|Ospreys 11 - 25 Munster|
|Newport Gwent D'gons 24 - 23 Glasgow|
|Benetton Treviso 12 - 14 Ulster|
|Saturday 22nd February|
|Scarlets 25 - 21 Edinburgh|
|Thursday 20th February|
|Cardiff Blues 22 - 34 Leinster|
|Sunday 16th February|
|Ospreys 75 - 7 Benetton Treviso|
|Saturday 15th February|
|Munster 36 - 8 Zebre|
|Cardiff Blues 20 - 27 Glasgow|
|Connacht 11 - 7 Edinburgh|
|Friday 14th February|
|Leinster 31 - 19 Newport Gwent D'gons|
|Sunday 9th February|
|Zebre 8 - 31 Leinster|
|Glasgow 8 - 6 Connacht|
|Saturday 8th February|
|Munster 54 - 13 Cardiff Blues|
|Benetton Treviso 33 - 41 Scarlets|
|Friday 7th February|
|Ulster 10 - 7 Ospreys|
Read the thoughts and opinions of Stuart Barnes with skysports.com