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Connacht will be hoping to halt Scarlets' blistering start to the new RaboDirect PRO12 season at the Sportsground.
The Welshmen have won their opening two fixtures and lead the way while Connacht gained a first win against Zebre last Friday.
The Scarlets have made eight changes to their starting XV for Saturday's PRO12 clash in Galway. Scarlets head coach Simon Easterby brings in a few new faces to his matchday squad and mixes up experience and youth with a number of player rotations for the contest.
Young Scarlets talent Jordan Williams gets his senior Scarlets debut at full-back where he replaces his namesake Liam Williams while new signing Australian Welsh-qualified second row Jake Ball is on the bench and gets his first opportunity to appear in his regional colours.
Wales international centre Jon Davies takes the captain's armband for the first time in his Scarlets rugby career.
Other changes to the back-line from last weekend's run-on side against Glasgow sees Gareth Davies replacing Tavis Knoyle at scrum-half, while Nick Reynolds comes in for Andy Fenby on the wing.
Amongst the forwards, Samson Lee starts at tight-head in his first competitive start and Phil John at loose-head prop, Sione Timani joins Richard Kelly in the second row. Lee takes over from Fiji international Deacon Manu while John and Timani come in for Rhodri Jones and George Earle respectively.
In the back row, Kieran Murphy starts at number eight with Scarlets skipper Rob McCusker on the bench and Josh Turnbull replaces Aaron Shingler on the flank.
Scarlets attack coach Mark Jones expects a tough assignment, commenting: "We haven't had a great record at the Sportsground and have tripped up on our last two visits with narrow losses, so we don't put ourselves in a position where we are fighting a tight margin at the end of the game.
"We will need to be ruthless and get ahead and then protect that lead. There is certainly no complacency in this side and absolutely no expectation on winning."
Connacht head coach Eric Elwood has made six changes to his run-on side for the encounter. Injury has forced an entire new back row and sees Andrew Browne named as blindside flanker.
This is Browne's first game back since he was injured during the 2011 pre-season. Willie Faloon and Eoin McKeon complete the all new back row and replace Johnny O'Connor and George Naopu respectively.
Brett Wilkinson will start in the loosehead prop position while new signing Nathan White gets his first start as tighthead prop. In the backs, Dave McSharry has been promoted to a starting berth, replacing Mata Fifita in the centre.
Elwood was very pleased with his team's performance in their 30-17 win over Zebre in Parma last week but knows there is a lot of work to do this weekend.
"We played well in Zebre scoring three tries away from home and securing our first win of the season," said Elwood. "The lads showed huge character in Italy, especially when we were forced into making so many changes in the second half.
"Tomorrow poses another challenge as Scarlets are top of the league and are playing very well. They've had a great start to the season, scoring 10 tries in the process."
Connacht: 15 Gavin Duffy (c), 14 Tiernan O'Halloran, 13 Eoin Griffin, 12 Dave McSharry, 11 Fetu'u Vainikolo, 10 Miah Nikora, 9 Kieran Marmion, 8 Eoin McKeon, 7 Willie Faloon, 6 Andrew Browne, 5 Mike McCarthy, 4 Michael Swift, 3 Nathan White, 2 Ethienne Reynecke, 1 Brett Wilkinson.
Replacements: 16 Adrian Flavin, 17 Dennis Buckley, 18 Rodney Ah You, 19 David Gannon, 20 Johnny O'Connor, 21 Dave Moore, 22 Matthew Jarvis, 23 Robbie Henshaw.
Scarlets: 15 Jordan Williams, 14 George North, 13 Jonathan Davies (c), 12 Scott Williams, 11 Nick Reynolds 10 Rhys Priestland, 9 Gareth Davies, 8 Kieran Murphy. 7 Johnathan Edwards, 6 Josh Turnbull, 5 Richard Kelly, 4 Sione Timani, 3 Samson Lee, 2 Matthew Rees, 1 Phil John.
Replacements: 16 Ken Owens, 17 Peter Edwards, 18 Deacon Manu, 19 Jake Ball, 20 Rob McCusker, 21 Aled Davies, 22 Aled Thomas, 23 Gareth Maule.
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|Friday 14th March|
|19:05||Ulster vs Scarlets|
|Friday 21st March|
|19:05||Ospreys vs Cardiff Blues|
|19:15||Leinster vs Zebre|
|19:45||Edinburgh vs Ulster|
|Saturday 22nd March|
|15:00||Glasgow vs Scarlets|
|19:15||Munster vs Benetton Treviso|
|Sunday 23rd March|
|15:05||Newport Gwent D'gons vs Connacht|
|Saturday 29th March|
|15:00||Zebre vs Newport Gwent D'gons|
|18:00||Benetton Treviso vs Edinburgh|
|18:30||Cardiff Blues vs Ulster|
|19:00||Leinster vs Munster|
|Sunday 30th March|
|14:05||Scarlets vs Connacht|
|Thursday 3rd April|
|18:30||Newport Gwent D'gons vs Edinburgh|
|Friday 11th April|
|19:05||Ulster vs Connacht|
|19:05||Ospreys vs Leinster|
|19:45||Edinburgh vs Cardiff Blues|
|Saturday 12th April|
|18:00||Benetton Treviso vs Newport Gwent D'gons|
|18:30||Munster vs Glasgow|
|18:30||Scarlets vs Zebre|
|Saturday 19th April|
|15:00||Zebre vs Edinburgh|
|15:00||Glasgow vs Ulster|
|15:00||Leinster vs Benetton Treviso|
|15:00||Connacht vs Munster|
|Sunday 20th April|
|14:00||Cardiff Blues vs Scarlets|
|16:45||Newport Gwent D'gons vs Ospreys|
|Saturday 1st March|
|Leinster 28 - 25 Glasgow|
|Scarlets 18 - 13 Munster|
|Connacht 38 - 6 Benetton Treviso|
|Zebre 15 - 10 Cardiff Blues|
|Friday 28th February|
|Edinburgh 31 - 25 Ospreys|
|Ulster 38 - 8 Newport Gwent D'gons|
|Sunday 23rd February|
|Zebre 19 - 27 Connacht|
|Ospreys 11 - 25 Munster|
|Newport Gwent D'gons 24 - 23 Glasgow|
|Benetton Treviso 12 - 14 Ulster|
|Saturday 22nd February|
|Scarlets 25 - 21 Edinburgh|
|Thursday 20th February|
|Cardiff Blues 22 - 34 Leinster|
|Sunday 16th February|
|Ospreys 75 - 7 Benetton Treviso|
|Saturday 15th February|
|Munster 36 - 8 Zebre|
|Cardiff Blues 20 - 27 Glasgow|
|Connacht 11 - 7 Edinburgh|
|Friday 14th February|
|Leinster 31 - 19 Newport Gwent D'gons|
|Sunday 9th February|
|Zebre 8 - 31 Leinster|
|Glasgow 8 - 6 Connacht|
|Saturday 8th February|
|Munster 54 - 13 Cardiff Blues|
|Benetton Treviso 33 - 41 Scarlets|
|Friday 7th February|
|Ulster 10 - 7 Ospreys|
Read the thoughts and opinions of Stuart Barnes with skysports.com