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Leinster and Edinburgh will be looking to pile the pressure on leaders Scarlets when the teams go head-to-head in Dublin.
Both have made decent starts to the new RaboDirect PRO12 season with two victories apiece from their opening three matches.
Leinster come into the game on the back of a 19-18 win at Benetton Treviso while Edinburgh trounced Zebre on home soil last weekend.
Leo Cullen skippers a Leinster side which shows several changes to the one which defeated Treviso.
Up front Sean Cronin comes into the front row in place of Richardt Strauss and he will line up alongside international colleagues Cian Healy (making his 98th Leinster appearance) and Mike Ross.
Cullen partners Tom Denton who will make his home debut for the province, with Jamie Heaslip, Shane Jennings and Kevin McLaughlin continuing in the back row.
Wexford's Gordon D'Arcy makes his first start of the season and he will line up at centre alongside Brian O'Driscoll who scored his 55th career try for the province on what was his 160th appearance. O'Driscoll is now one ahead of D'Arcy in third place and four behind Denis Hickie's tally of 59 tries. Shane Horgan leads the all-time list on 71 tries.
Isa Nacewa returns to the starting line-up and he is named in the back three alongside Fionn Carr and Andrew Conway.
Jonathan Sexton's 14 point haul in Italy pushed him past the 800 point mark for Leinster (808 points) and the St. Mary's College out-half will make his 94thappearance on Saturday, partnering Eoin Reddan at half back.
A formidable adversary in Dublin, Leinster have lost just two games at the Showground last season, with Edinburgh's last win in the Irish capital dating back to 2005.
"Leinster have consistently been the in-form side in northern hemisphere rugby, winning three Heineken Cups and finishing in the top three of the RaboDirect PRO12 for the past eight years, narrowly missing out on the league title at the RDS last season," said Edinburgh head coach Michael Bradley.
"I've been impressed by the willingness to be meticulous in our preparations and go the extra mile this season. We will be well-prepared to face Leinster in Dublin."
Bradley has made three changes to the side that put five tries past Zebre at Murrayfield last weekend, taking the opportunity to rest try-machine Tim Visser with Tom Brown now back to full fitness.
In the pack, the return of prop Geoff Cross and flanker Roddy Grant completes the changes to the front-line, while a quality quartet of youngsters are set for their first competitive outing of the season from the bench: Robin Hislop, Robert McAlpine, Harry Leonard and Dougie Fife.
Leinster: 15 Isa Nacewa, 14 Andrew Conway, 13 Brian O'Driscoll, 12 Gordon D'Arcy, 11 Fionn Carr, 10 Jonathan Sexton, 9 Eoin Reddan, 8 Jamie Heaslip, 7 Shane Jennings, 6 Kevin McLaughlin, 5 Tom Denton, 4 Leo Cullen (c), 3 Mike Ross, 2 Sean Cronin, 1 Cian Healy.
Replacements: 16 Tom Sexton, 17 Heinke van der Merwe, 18 Jamie Hagan, 19 Devin Toner, 20 Jordi Murphy, 21 John Cooney, 22 Ian Madigan, 23 Brendan Macken.
Edinburgh: 15 Greig Tonks, 14 Lee Jones, 13 Nick De Luca, 12 Matt Scott, 11 Tom Brown, 10 Greig Laidlaw (c), 9 Richie Rees, 8 Netani Talei, 7 Roddy Grant, 6 Stuart McInally, 5 Sean Cox, 4 Grant Gilchrist, 3 Geoff Cross, 2 Ross Ford, 1 John Yapp.
Replacements: 16 Andy Titterrell, 17 Robin Hislop, 18 Willem Nel1, 9 Robert McAlpine, 20 Dimitri Basilaia, 21 Chris Leck, 22 Harry Leonard, 23 Dougie Fife.
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|Friday 18th April|
|17:00||Leinster vs Benetton Treviso|
|19:35||Glasgow vs Ulster|
|Saturday 19th April|
|14:30||Zebre vs Edinburgh|
|18:15||Connacht vs Munster|
|Sunday 20th April|
|14:00||Cardiff Blues vs Scarlets|
|16:45||Newport Gwent D'gons vs Ospreys|
|Saturday 26th April|
|19:05||Glasgow vs Edinburgh|
|Thursday 1st May|
|17:00||Zebre vs Ospreys|
|Friday 2nd May|
|19:00||Benetton Treviso vs Glasgow|
|19:05||Scarlets vs Newport Gwent D'gons|
|19:30||Ulster vs Leinster|
|Saturday 3rd May|
|17:00||Edinburgh vs Munster|
|17:00||Connacht vs Cardiff Blues|
|Saturday 10th May|
|18:30||Leinster vs Edinburgh|
|18:30||Ospreys vs Connacht|
|18:30||Newport Gwent D'gons vs Benetton Treviso|
|18:30||Munster vs Ulster|
|18:30||Scarlets vs Cardiff Blues|
|18:30||Glasgow vs Zebre|
|Saturday 12th April|
|Munster 5 - 22 Glasgow|
|Scarlets 27 - 20 Zebre|
|Benetton Treviso 45 - 27 Newport Gwent D'gons|
|Friday 11th April|
|Edinburgh 22 - 29 Cardiff Blues|
|Ulster 58 - 12 Connacht|
|Ospreys 25 - 19 Leinster|
|Friday 4th April|
|Glasgow 29 - 10 Benetton Treviso|
|Thursday 3rd April|
|Newport Gwent D'gons 19 - 23 Edinburgh|
|Sunday 30th March|
|Scarlets 32 - 30 Connacht|
|Saturday 29th March|
|Leinster 22 - 18 Munster|
|Cardiff Blues 28 - 23 Ulster|
|Benetton Treviso 20 - 16 Edinburgh|
|Zebre 25 - 25 Newport Gwent D'gons|
|Friday 28th March|
|Glasgow 11 - 9 Ospreys|
|Sunday 23rd March|
|Newport Gwent D'gons 8 - 24 Connacht|
|Saturday 22nd March|
|Munster 14 - 3 Benetton Treviso|
|Glasgow 14 - 6 Scarlets|
|Friday 21st March|
|Edinburgh 3 - 9 Ulster|
|Leinster 27 - 0 Zebre|
|Ospreys 34 - 9 Cardiff Blues|
|Friday 14th March|
|Ulster 26 - 13 Scarlets|
|Saturday 1st March|
|Leinster 28 - 25 Glasgow|
|Scarlets 18 - 13 Munster|
|Connacht 38 - 6 Benetton Treviso|
|Zebre 15 - 10 Cardiff Blues|
Read the thoughts and opinions of Stuart Barnes with skysports.com