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Defending RaboDirect PRO12 champions Ospreys go in search of their fourth successive victory when they tackle Connacht at the Liberty Stadium on Saturday.
The home side have made two changes to their starting side as blindside flanker Joe Bearman and tighthead prop Aaron Jarvis come in for Ryan Jones and Adam Jones.
The backline remains unchanged as the Welsh region look to bounce back from their disappointing Heineken Cup finish against Leicester at Welford Road last weekend.
Connacht coach Eric Elwood has made seven changes. Two of those changes are positional with George Naoupu moving from his regular number eight position to lock in place of an injured Mike McCarthy while Robbie Henshaw replaces Eoin Griffin.
Mata Fifita replaces Dave McSharry and joins Henshaw in the new centre partnership. Darragh Leader, 19, earns his first competitive start for the province at full-back.
On the bench, former Stormers player Danie Poolman is set to make his first appearance for the province. Rodney Ah You and Dave Gannon also return to the bench as forwards.
Ospreys: 15 Richard Fussell, 14 Hanno Dirksen, 13 Andrew Bishop, 12 Ashley Beck, 11 Eli Walker, 10 Dan Biggar, 9 Kahn Fotuali'i, 8 Jonathan Thomas, 7 Justin Tipuric, 6 Joe Bearman, 5 Ian Evans, 4 Alun Wyn Jones (cpt), 3 Aaron Jarvis, 2 Richard Hibbard, 1 Ryan Bevington.
Replacements: 16 Matthew Dwyer, 17 Duncan Jones, 18 Joe Rees, 19 James King, 20 George Stowers, 21 Rhys Webb, 22 Matthew Morgan, 23 Tom Isaacs.
Connacht: 15 Darragh Leader, 14 Tiernan O'Halloran, 13 Robbie Henshaw, 12 Mata Fifita, 11 Fetu'u Vainikolo, 10 Dan Parks, 9 Kieran Marmion, 8 Eoin McKeon, 7 Willie Faloon, 6 John Muldoon, 5 George Naoupu, 4 Michael Swift, 3 Nathan White (cpt), 2 Jason Harris-Wright, 1 Brett Wilkinson.
Replacements: 16 Adrian Flavin, 17 Ronan Loughney, 18 Rodney Ah You, 19 Dave Gannon, 20 Johnny O'Connor, 21 Dave Moore, 22 Miah Nikora, 23 Danie Poolman.
"Connacht are a very dangerous team, Eric Elwood has taken what was already a tough, physical group and looked to expand their game," said Humphreys.
"We know that we are going to have be well prepared, diligent and focused if we are going to get what we want out of this fixture, and it'll need to be a real team effort on and off the field."
"Over the years, we've had huge physical encounters with the Welsh side and we'll be expecting the same this weekend. It's another big challenge but we take great encouragement from our performances of the last few weeks," he Elwood.
"Last Saturday, we went toe-to-toe with the English champions and competed with them for the 80 minutes. We played some great rugby and we'll be looking to do the same this weekend against the Ospreys.
"We know it's going to be a hugely physical battle but we're very much looking forward to the test. The goal for us is to keep improving and continue on our upward curve."
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|Friday 21st March|
|19:05||Ospreys vs Cardiff Blues|
|19:15||Leinster vs Zebre|
|19:45||Edinburgh vs Ulster|
|Saturday 22nd March|
|18:30||Glasgow vs Scarlets|
|19:15||Munster vs Benetton Treviso|
|Sunday 23rd March|
|15:05||Newport Gwent D'gons vs Connacht|
|Saturday 29th March|
|15:00||Zebre vs Newport Gwent D'gons|
|18:00||Benetton Treviso vs Edinburgh|
|18:30||Cardiff Blues vs Ulster|
|19:00||Leinster vs Munster|
|Sunday 30th March|
|14:05||Scarlets vs Connacht|
|Thursday 3rd April|
|18:30||Newport Gwent D'gons vs Edinburgh|
|Friday 11th April|
|19:05||Ulster vs Connacht|
|19:05||Ospreys vs Leinster|
|19:45||Edinburgh vs Cardiff Blues|
|Saturday 12th April|
|18:00||Benetton Treviso vs Newport Gwent D'gons|
|18:30||Munster vs Glasgow|
|18:30||Scarlets vs Zebre|
|Saturday 19th April|
|15:00||Zebre vs Edinburgh|
|15:00||Glasgow vs Ulster|
|15:00||Leinster vs Benetton Treviso|
|15:00||Connacht vs Munster|
|Sunday 20th April|
|14:00||Cardiff Blues vs Scarlets|
|16:45||Newport Gwent D'gons vs Ospreys|
|Saturday 3rd May|
|15:00||Zebre vs Ospreys|
|Friday 14th March|
|Ulster 26 - 13 Scarlets|
|Saturday 1st March|
|Leinster 28 - 25 Glasgow|
|Scarlets 18 - 13 Munster|
|Connacht 38 - 6 Benetton Treviso|
|Zebre 15 - 10 Cardiff Blues|
|Friday 28th February|
|Edinburgh 31 - 25 Ospreys|
|Ulster 38 - 8 Newport Gwent D'gons|
|Sunday 23rd February|
|Zebre 19 - 27 Connacht|
|Ospreys 11 - 25 Munster|
|Newport Gwent D'gons 24 - 23 Glasgow|
|Benetton Treviso 12 - 14 Ulster|
|Saturday 22nd February|
|Scarlets 25 - 21 Edinburgh|
|Thursday 20th February|
|Cardiff Blues 22 - 34 Leinster|
|Sunday 16th February|
|Ospreys 75 - 7 Benetton Treviso|
|Saturday 15th February|
|Munster 36 - 8 Zebre|
|Cardiff Blues 20 - 27 Glasgow|
|Connacht 11 - 7 Edinburgh|
|Friday 14th February|
|Leinster 31 - 19 Newport Gwent D'gons|
|Sunday 9th February|
|Zebre 8 - 31 Leinster|
|Glasgow 8 - 6 Connacht|
|Saturday 8th February|
|Munster 54 - 13 Cardiff Blues|
|Benetton Treviso 33 - 41 Scarlets|
|Friday 7th February|
|Ulster 10 - 7 Ospreys|
Read the thoughts and opinions of Stuart Barnes with skysports.com