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Defending RaboDirect PRO12 champions Ospreys go in search of their fourth successive victory when they tackle Connacht at the Liberty Stadium on Saturday.
The home side have made two changes to their starting side as blindside flanker Joe Bearman and tighthead prop Aaron Jarvis come in for Ryan Jones and Adam Jones.
The backline remains unchanged as the Welsh region look to bounce back from their disappointing Heineken Cup finish against Leicester at Welford Road last weekend.
Connacht coach Eric Elwood has made seven changes. Two of those changes are positional with George Naoupu moving from his regular number eight position to lock in place of an injured Mike McCarthy while Robbie Henshaw replaces Eoin Griffin.
Mata Fifita replaces Dave McSharry and joins Henshaw in the new centre partnership. Darragh Leader, 19, earns his first competitive start for the province at full-back.
On the bench, former Stormers player Danie Poolman is set to make his first appearance for the province. Rodney Ah You and Dave Gannon also return to the bench as forwards.
Ospreys: 15 Richard Fussell, 14 Hanno Dirksen, 13 Andrew Bishop, 12 Ashley Beck, 11 Eli Walker, 10 Dan Biggar, 9 Kahn Fotuali'i, 8 Jonathan Thomas, 7 Justin Tipuric, 6 Joe Bearman, 5 Ian Evans, 4 Alun Wyn Jones (cpt), 3 Aaron Jarvis, 2 Richard Hibbard, 1 Ryan Bevington.
Replacements: 16 Matthew Dwyer, 17 Duncan Jones, 18 Joe Rees, 19 James King, 20 George Stowers, 21 Rhys Webb, 22 Matthew Morgan, 23 Tom Isaacs.
Connacht: 15 Darragh Leader, 14 Tiernan O'Halloran, 13 Robbie Henshaw, 12 Mata Fifita, 11 Fetu'u Vainikolo, 10 Dan Parks, 9 Kieran Marmion, 8 Eoin McKeon, 7 Willie Faloon, 6 John Muldoon, 5 George Naoupu, 4 Michael Swift, 3 Nathan White (cpt), 2 Jason Harris-Wright, 1 Brett Wilkinson.
Replacements: 16 Adrian Flavin, 17 Ronan Loughney, 18 Rodney Ah You, 19 Dave Gannon, 20 Johnny O'Connor, 21 Dave Moore, 22 Miah Nikora, 23 Danie Poolman.
"Connacht are a very dangerous team, Eric Elwood has taken what was already a tough, physical group and looked to expand their game," said Humphreys.
"We know that we are going to have be well prepared, diligent and focused if we are going to get what we want out of this fixture, and it'll need to be a real team effort on and off the field."
"Over the years, we've had huge physical encounters with the Welsh side and we'll be expecting the same this weekend. It's another big challenge but we take great encouragement from our performances of the last few weeks," he Elwood.
"Last Saturday, we went toe-to-toe with the English champions and competed with them for the 80 minutes. We played some great rugby and we'll be looking to do the same this weekend against the Ospreys.
"We know it's going to be a hugely physical battle but we're very much looking forward to the test. The goal for us is to keep improving and continue on our upward curve."
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|Friday 20th December|
|19:05||Cardiff Blues vs Ospreys|
|19:05||Ulster vs Zebre|
|19:35||Glasgow vs Benetton Treviso|
|19:35||Edinburgh vs Leinster|
|Saturday 21st December|
|17:00||Connacht vs Newport Gwent D'gons|
|19:15||Munster vs Scarlets|
|Thursday 26th December|
|14:00||Scarlets vs Ospreys|
|15:05||Edinburgh vs Glasgow|
|17:00||Newport Gwent D'gons vs Cardiff Blues|
|Friday 27th December|
|19:15||Munster vs Connacht|
|Saturday 28th December|
|15:00||Benetton Treviso vs Zebre|
|18:45||Leinster vs Ulster|
|Wednesday 1st January|
|14:05||Cardiff Blues vs Newport Gwent D'gons|
|18:05||Glasgow vs Edinburgh|
|Friday 3rd January|
|19:05||Ulster vs Munster|
|Saturday 4th January|
|15:00||Zebre vs Benetton Treviso|
|15:00||Connacht vs Leinster|
|15:00||Ospreys vs Scarlets|
|Saturday 8th February|
|15:00||Benetton Treviso vs Scarlets|
|15:00||Newport Gwent D'gons vs Edinburgh|
|15:00||Glasgow vs Connacht|
|15:00||Zebre vs Leinster|
|15:00||Ulster vs Ospreys|
|15:00||Munster vs Cardiff Blues|
|Saturday 15th February|
|15:00||Connacht vs Edinburgh|
|Saturday 30th November|
|Leinster 36 - 19 Scarlets|
|Benetton Treviso 26 - 26 Cardiff Blues|
|Zebre 11 - 19 Ulster|
|Friday 29th November|
|Edinburgh 43 - 10 Connacht|
|Newport Gwent D'gons 14 - 18 Munster|
|Ospreys 16 - 28 Glasgow|
|Sunday 24th November|
|Benetton Treviso 20 - 21 Leinster|
|Saturday 23rd November|
|Cardiff Blues 10 - 31 Munster|
|Connacht 21 - 24 Scarlets|
|Ospreys 30 - 20 Zebre|
|Friday 22nd November|
|Glasgow 8 - 23 Newport Gwent D'gons|
|Ulster 41 - 17 Edinburgh|
|Saturday 2nd November|
|Munster 12 - 6 Ospreys|
|Scarlets 17 - 9 Ulster|
|Connacht 12 - 19 Glasgow|
|Cardiff Blues 17 - 13 Benetton Treviso|
|Friday 1st November|
|Edinburgh 25 - 23 Zebre|
|Newport Gwent D'gons 19 - 23 Leinster|
|Saturday 26th October|
|Leinster 16 - 13 Connacht|
|Friday 25th October|
|Edinburgh 20 - 13 Benetton Treviso|
|Glasgow 6 - 13 Munster|
|Ulster 39 - 21 Cardiff Blues|
|Ospreys 40 - 17 Newport Gwent D'gons|
|Zebre 16 - 16 Scarlets|
Read the thoughts and opinions of Stuart Barnes with skysports.com