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Newport Gwent Dragons have made wholesale changes to their side ahead of Saturday's encounter with Scarlets at the Millennium Stadium.
Welsh team officials have championed this weekend's RaboDirect PRO12 fixtures with two derbies on offer.
First up the Dragons take on Scarlets, before Cardiff Blues face the Ospreys in a double-header at the national stadium.
Wales internationals Toby Faletau and Dan Lydiate are named in the Dragons back row alongside Nic Cudd who retains his place at openside flanker.
But they are without loosehead prop Phil Price, who will undergo knee surgery next week, although Aaron Coundley, Hugh Gustafson and Dan Way all return to the front row.
Following a successful Six Nations campaign with Wales Andrew Coombs leads the Dragons out as they make their first appearance at the national stadium.
Meanwhile, the Scarlets welcome their Wales international contingent back to the starting line-up as coach Simon Easterby seeks a third successive victory.
Centres Jonathan Davies and Scott Williams return to the side with Gareth Maule dropping to the bench and Adam Warren left out of the squad.
On the wings George North and Liam Williams get the nod leaving Andy Fenby out of side while Matthew Rees starts at hooker.
Dragons: 15 Tom Prydie, 14 Will Harries, 13 Pat Leach, 12 Jack Dixon, 11 Ross Wardle, 10 Dan Evans, 9 Jonathan Evans, 8 Toby Faletau 7 Nic Cudd, 6 Dan Lydiate, 5 Rob Sidoli, 4 Andrew Coombs (capt), 3 Dan Way, 2 Hugh Gustafson, 1 Aaron Coundley. Replacements: 16 Sam Parry, 17 Owen Evans, 18 Nathan Buck, 19 Jevon Groves, 20 Ieuan Jones, 21 Wayne Evans, 22 Steffan Jones, 23 Adam Hughes.
Scarlets: 15 Gareth Owen, 14 George North, 13 Jonathan Davies, 12 Scott Williams, 11 Liam Williams, 10 Owen Williams, 9 Aled Davies, 8 Rob McCusker (capt), 7 Johnathan Edwards, 6 Aaron Shingler, 5 Johan Synman, 4 George Earle, 3 Samson Lee, 2 Matthew Rees, 1 Phil John.
Replacements: 16 Ken Owens, 17 Rhodri Jones, 18 Deacon Manu, 19 Sione Timani, 20 Josh Turnbull, 21 Rhodri Williams, 22 Aled Thomas, 23 Gareth Maule.
"The boys have prepared well - it's been an intense training week at Parc y Scarlets with plenty of competition to get into the starting XV which has really added an edge," he told the club's official website.
"The Millennium Stadium is a special place for both the players and the fans and it's a great concept to have these two derby matches here on the same day the atmosphere will be amazing," he told the club's official website.
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|Friday 20th December|
|19:05||Cardiff Blues vs Ospreys|
|19:05||Ulster vs Zebre|
|19:35||Glasgow vs Benetton Treviso|
|19:35||Edinburgh vs Leinster|
|Saturday 21st December|
|17:00||Connacht vs Newport Gwent D'gons|
|19:15||Munster vs Scarlets|
|Thursday 26th December|
|14:00||Scarlets vs Ospreys|
|15:05||Edinburgh vs Glasgow|
|17:00||Newport Gwent D'gons vs Cardiff Blues|
|Friday 27th December|
|19:15||Munster vs Connacht|
|Saturday 28th December|
|15:00||Benetton Treviso vs Zebre|
|18:45||Leinster vs Ulster|
|Wednesday 1st January|
|14:05||Cardiff Blues vs Newport Gwent D'gons|
|18:05||Glasgow vs Edinburgh|
|Friday 3rd January|
|19:05||Ulster vs Munster|
|Saturday 4th January|
|15:00||Zebre vs Benetton Treviso|
|15:00||Connacht vs Leinster|
|15:00||Ospreys vs Scarlets|
|Saturday 8th February|
|15:00||Benetton Treviso vs Scarlets|
|15:00||Newport Gwent D'gons vs Edinburgh|
|15:00||Glasgow vs Connacht|
|15:00||Zebre vs Leinster|
|15:00||Ulster vs Ospreys|
|15:00||Munster vs Cardiff Blues|
|Saturday 15th February|
|15:00||Connacht vs Edinburgh|
|Saturday 30th November|
|Leinster 36 - 19 Scarlets|
|Benetton Treviso 26 - 26 Cardiff Blues|
|Zebre 11 - 19 Ulster|
|Friday 29th November|
|Edinburgh 43 - 10 Connacht|
|Newport Gwent D'gons 14 - 18 Munster|
|Ospreys 16 - 28 Glasgow|
|Sunday 24th November|
|Benetton Treviso 20 - 21 Leinster|
|Saturday 23rd November|
|Cardiff Blues 10 - 31 Munster|
|Connacht 21 - 24 Scarlets|
|Ospreys 30 - 20 Zebre|
|Friday 22nd November|
|Glasgow 8 - 23 Newport Gwent D'gons|
|Ulster 41 - 17 Edinburgh|
|Saturday 2nd November|
|Munster 12 - 6 Ospreys|
|Scarlets 17 - 9 Ulster|
|Connacht 12 - 19 Glasgow|
|Cardiff Blues 17 - 13 Benetton Treviso|
|Friday 1st November|
|Edinburgh 25 - 23 Zebre|
|Newport Gwent D'gons 19 - 23 Leinster|
|Saturday 26th October|
|Leinster 16 - 13 Connacht|
|Friday 25th October|
|Edinburgh 20 - 13 Benetton Treviso|
|Glasgow 6 - 13 Munster|
|Ulster 39 - 21 Cardiff Blues|
|Ospreys 40 - 17 Newport Gwent D'gons|
|Zebre 16 - 16 Scarlets|
Read the thoughts and opinions of Stuart Barnes with skysports.com