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Zebre will make their first-ever home appearance in PRO12 action when they host Connacht on Friday.
The Italian team kicked off the new season with a 37-6 loss at Newport Gwent Dragons while Connacht were defeated at home to the Cardiff Blues.
Stadio XXV Aprile becomes the 36th different ground, and the third in Italy, to host a game in the history of this competition.
French-born coach Christian Gajan has made four changes in the starting line-up following the defeat suffered in Newport in the first round.
21-year-old Alberto Benettin is making his debut for the new Italian franchise starting at outside centre replacing injured team-mate Roberto Quartaroli, while Emerging Italy scrum-half Alberto Chillon wins his first start in place of Tito Tebaldi.
Among the forwards, veteran flanker Mauro Bergamasco - recovered from a muscle injury suffered during summer friendlies - makes his first start for Zebre replacing Nicola Cattina, while former Italian international Josh Sole starts as lock in place of Caffini who drops to the bench.
Tighthead prop David Ryan will once again lock horns with Italian internationals Salvatore Perugini and Carlo Festuccia up front.
Meanwhile, Connacht have named an unchanged starting XV.
There are two changes on the bench with Nathan White taking the place of Finlay Bealham and Frank Murphy stepping in for Dave Moore.
Connacht will be looking to convert last week's possession and opportunities into points this week. Despite crossing the tryline twice in the first half and hour, handling errors denied the home side a try which would have made all the difference playing into the strong wind.
Zebre: 15 Sinoti Sinoti, 14 Giovanbattista Venditti, 13 Alberto Benettin, 12 Gonzalo Garcia (c), 11 Samuele Pace, 10 Luciano Orquera, 9 Alberto Chillon , 8 Andries Van Schalkwyk, 7 Mauro Bergamasco, 6 Filippo Cristiano, 5 Josh Sole, 4 Quintin Geldenhuys, 3 David Ryan, 2 Carlo Festuccia, 1 Salvatore Perugini.
Replacements: 16 Davide Giazzon, 17 Andrea De Marchie, 18 Luca Redolfini, 19 Emiliano Caffini, 20 Nicola Belardo, 21 Tito Tebaldi, 22 Alberto Chiesa, 23 Ruggero Trevisan.
Connacht:15 Gavin Duffy (c), 14 Tiernan O'Halloran, 13 Eoin Griffin, 12 Mata Fifita, 11 Fetu'u Vainikolo, 10 Miah Nikora, 9 Kieran Marmion, 8 George Naoupu, 7 Johnny O'Connor, 6 John Muldoon, 5 Mike McCarthy, 4 Michael Swift, 3 Ronan Loughney, 2 Ethienne Reynecke, 1 Denis Buckley.
Replacements: 16 Adrian Flavin, 17 Rodney Ah You, 18 Nathan White, 19 Dave Gannon, 20 Willie Faloon, 21 Frank Murphy, 22 Matthew Jarvis, 23 Robbie Henshaw.
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|Friday 18th April|
|17:00||Leinster vs Benetton Treviso|
|19:35||Glasgow vs Ulster|
|Saturday 19th April|
|14:30||Zebre vs Edinburgh|
|18:15||Connacht vs Munster|
|Sunday 20th April|
|14:00||Cardiff Blues vs Scarlets|
|16:45||Newport Gwent D'gons vs Ospreys|
|Saturday 26th April|
|19:05||Glasgow vs Edinburgh|
|Thursday 1st May|
|17:00||Zebre vs Ospreys|
|Friday 2nd May|
|19:00||Benetton Treviso vs Glasgow|
|19:05||Scarlets vs Newport Gwent D'gons|
|19:30||Ulster vs Leinster|
|Saturday 3rd May|
|17:00||Edinburgh vs Munster|
|17:00||Connacht vs Cardiff Blues|
|Saturday 10th May|
|18:30||Leinster vs Edinburgh|
|18:30||Ospreys vs Connacht|
|18:30||Newport Gwent D'gons vs Benetton Treviso|
|18:30||Munster vs Ulster|
|18:30||Scarlets vs Cardiff Blues|
|18:30||Glasgow vs Zebre|
|Saturday 12th April|
|Munster 5 - 22 Glasgow|
|Scarlets 27 - 20 Zebre|
|Benetton Treviso 45 - 27 Newport Gwent D'gons|
|Friday 11th April|
|Edinburgh 22 - 29 Cardiff Blues|
|Ulster 58 - 12 Connacht|
|Ospreys 25 - 19 Leinster|
|Friday 4th April|
|Glasgow 29 - 10 Benetton Treviso|
|Thursday 3rd April|
|Newport Gwent D'gons 19 - 23 Edinburgh|
|Sunday 30th March|
|Scarlets 32 - 30 Connacht|
|Saturday 29th March|
|Leinster 22 - 18 Munster|
|Cardiff Blues 28 - 23 Ulster|
|Benetton Treviso 20 - 16 Edinburgh|
|Zebre 25 - 25 Newport Gwent D'gons|
|Friday 28th March|
|Glasgow 11 - 9 Ospreys|
|Sunday 23rd March|
|Newport Gwent D'gons 8 - 24 Connacht|
|Saturday 22nd March|
|Munster 14 - 3 Benetton Treviso|
|Glasgow 14 - 6 Scarlets|
|Friday 21st March|
|Edinburgh 3 - 9 Ulster|
|Leinster 27 - 0 Zebre|
|Ospreys 34 - 9 Cardiff Blues|
|Friday 14th March|
|Ulster 26 - 13 Scarlets|
|Saturday 1st March|
|Leinster 28 - 25 Glasgow|
|Scarlets 18 - 13 Munster|
|Connacht 38 - 6 Benetton Treviso|
|Zebre 15 - 10 Cardiff Blues|
Read the thoughts and opinions of Stuart Barnes with skysports.com