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Two winless teams go head-to-head on Friday night as champions Ospreys take on the Glasgow Warriors at Liberty Stadium.
Ospreys followed up their opening weekend loss to Benetton by losing at home to Ulster earlier this month.
The Warriors have not fared any better, suffering back-to-back defeats to Ulster and Scarlets.
The omens are good for Glasgow as they have lost just one of their last nine matches against the Welsh regions.
Left wing Tom Grabham will make his first competitive start for the Ospreys in Friday's PRO12 clash.
The likes of Ryan Jones, Eli Walker, James Goode, Tom Habberfield, Tom Isaacs, James King, Tom Smith, Jonathan Thomas, Adam Jones are all ruled out due to injury.
Ospreys head coach Steve Tandy believes a win is vital for his troops.
"This is an important game for us, against a very good, very powerful and very dangerous Glasgow team. Like us they'll be disappointed at the start they've had, but we know they are a real threat," he said.
"They were in the PRO12 semis last season, as they were two years ago, and just as we haven't become a bad team on the back of two defeats neither have they.
"We aren't that far away from where we want to be, but in reality we need big improvements in application, discipline and accuracy if we are going to turn possession and chances into wins."
There are six changes to Glasgow's starting XV that ran out against the Scarlets.
With Pat MacArthur nursing a fractured foot and Moray Low a calf complaint, Dougie Hall starts at hooker and Mike Cusack at tight-head prop. In the back-row, John Barclay moves to blindside flanker with Chris Fusaro coming in at openside.
The backline switches see Duncan Weir replace Ruaridh Jackson at stand-off, Tommy Semour get the nod over Sean Lamont on the right wing, and Peter Horne (pictured) start at inside centre.
Head coach Gregor Townsend explained: "As a coaching group, we strongly believe this team has the necessary attributes to win Friday's game.
"We're sending out an experienced pack, and are happy with the balance of the combinations in there.
"We know this is going to be another very challenging match, but as a group, we're primed to deliver the result that we and our supporters all want."
Ospreys: 15 Richard Fussell, 14 Hanno Dirksen, 13 Jonathan Spratt, 12 Ashley Beck, 11 Tom Grabham, 10 Dan Biggar, 9 Rhys Webb, 8 Joe Bearman, 7 Justin Tipuric (c), 6 George Stowers, 5 Ian Evans, 4 Ian Gough, 3 Aaron Jarvis, 2 Richard Hibbard, 1 Duncan Jones.
Replacements: 16 Scott Baldwin, 17 Ryan Bevington, 18 Joe Rees, 19 Alun Wyn Jones, 20 Sam Lewis, 21 Kahn Fotuali'i, 22 Matthew Morgan, 23 Andrew Bishop.
Glasgow Warriors:15 Peter Murchie, 14 Tommy Seymour, 13 Alex Dunbar, 12 Peter Horne, 11 DTH van der Merwe, 10 Duncan Weir, 9 Chris Cusiter, 8 Ryan Wilson, 7 Chris Fusaro, 6 John Barclay, 5 Al Kellock (c), 4 Tom Ryder, 3 Mike Cusack, 2 Dougie Hall, 1 Ryan Grant.
Replacements: 16 Finlay Gillies, 17 George Hunter 18 Gordon Reid, 19 James Eddie, 20 Angus Macdonald, 21 Henry Pyrgos, 22 Ruaridh Jackson, 23 Sean Lamont.
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|Friday 20th December|
|19:05||Cardiff Blues vs Ospreys|
|19:05||Ulster vs Zebre|
|19:35||Glasgow vs Benetton Treviso|
|19:35||Edinburgh vs Leinster|
|Saturday 21st December|
|17:00||Connacht vs Newport Gwent D'gons|
|19:15||Munster vs Scarlets|
|Thursday 26th December|
|14:00||Scarlets vs Ospreys|
|15:05||Edinburgh vs Glasgow|
|17:00||Newport Gwent D'gons vs Cardiff Blues|
|Friday 27th December|
|19:15||Munster vs Connacht|
|Saturday 28th December|
|15:00||Benetton Treviso vs Zebre|
|18:45||Leinster vs Ulster|
|Wednesday 1st January|
|14:05||Cardiff Blues vs Newport Gwent D'gons|
|18:05||Glasgow vs Edinburgh|
|Friday 3rd January|
|19:05||Ulster vs Munster|
|Saturday 4th January|
|15:00||Zebre vs Benetton Treviso|
|15:00||Connacht vs Leinster|
|15:00||Ospreys vs Scarlets|
|Saturday 8th February|
|15:00||Benetton Treviso vs Scarlets|
|15:00||Newport Gwent D'gons vs Edinburgh|
|15:00||Glasgow vs Connacht|
|15:00||Zebre vs Leinster|
|15:00||Ulster vs Ospreys|
|15:00||Munster vs Cardiff Blues|
|Saturday 15th February|
|15:00||Connacht vs Edinburgh|
|Saturday 30th November|
|Leinster 36 - 19 Scarlets|
|Benetton Treviso 26 - 26 Cardiff Blues|
|Zebre 11 - 19 Ulster|
|Friday 29th November|
|Edinburgh 43 - 10 Connacht|
|Newport Gwent D'gons 14 - 18 Munster|
|Ospreys 16 - 28 Glasgow|
|Sunday 24th November|
|Benetton Treviso 20 - 21 Leinster|
|Saturday 23rd November|
|Cardiff Blues 10 - 31 Munster|
|Connacht 21 - 24 Scarlets|
|Ospreys 30 - 20 Zebre|
|Friday 22nd November|
|Glasgow 8 - 23 Newport Gwent D'gons|
|Ulster 41 - 17 Edinburgh|
|Saturday 2nd November|
|Munster 12 - 6 Ospreys|
|Scarlets 17 - 9 Ulster|
|Connacht 12 - 19 Glasgow|
|Cardiff Blues 17 - 13 Benetton Treviso|
|Friday 1st November|
|Edinburgh 25 - 23 Zebre|
|Newport Gwent D'gons 19 - 23 Leinster|
|Saturday 26th October|
|Leinster 16 - 13 Connacht|
|Friday 25th October|
|Edinburgh 20 - 13 Benetton Treviso|
|Glasgow 6 - 13 Munster|
|Ulster 39 - 21 Cardiff Blues|
|Ospreys 40 - 17 Newport Gwent D'gons|
|Zebre 16 - 16 Scarlets|
Read the thoughts and opinions of Stuart Barnes with skysports.com