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Zebre will hand a debut to former Waratahs playmaker Daniel Halangahu in Friday's PRO12 clash with Edinburgh at Murrayfield.
Halangahu's first appearance is one of a number of changes made by director of rugby Christian Gajan to the starting XV following the home loss to Connacht last week.
Centre Matteo Pratichetti wins his first ever cap in a Zebre shirt in an all-new midfield, while Alberto Chiesa is handed the fly-half role ahead of Luciano Orquera and Tito Tebaldi features at scrum-half.
On the bench, full-back Paolo Buso and young hooker Andrea Manici are also set for debuts.
Italian international lock Quintin Geldenhuys will be Zebre's skipper for the game in the place of the injured Gonzalo Garcia; veteran second-rower Marco Bortolami is also sidelined.
"This week we worked a lot on the effectiveness of our game: in this is what we're missing,"said Gajan.
"In the first two games we lost too many balls that we had cleverly obtained. For this game we decided to select players who have played less, in order to grow our youngsters"
Meanwhile, Edinburgh have made five changes to the side that started against Cardiff Blues.
Inside centre Matt Scott, who started every match of the Scotland's three-Test June triumph in Australasia, returns for his first match of the new campaign.
The remaining changes come in the pack, with props John Yapp and Willem Nel trading places with Allan Jacobsen and Geoff Cross, who start on the bench.
Scotland's Ross Rennie and Netani Talei of Fiji replace Roddy Grant and the injured David Denton (thigh) in the second row.
Also returning to the squad is Tom Brown, who continues his comeback from a hamstring strain as replacement.
Edinburgh: 15 Greig Tonks, 14 Lee Jones, 13 Nick De Luca, 12 Matt Scott, 11 Tim Visser, 10 Greig Laidlaw (capt), 9 Richie Rees, 8 Netani Talei, 7 Ross Rennie, 6 Stuart McInally, 5 Sean Cox, 4 Grant Gilchrist, 3 Willem Nel, 2 Ross Ford, 1 John Yapp.
Replacements: 16 Andy Titterrell, 17 Allan Jacobsen, 18 Geoff Cross, 19 Perry Parker, 20 Dimitri Basilaia, 21 Chris Leck, 22 John Houston, 23 Tom Brown.
Zebre: 15 Sinoti Sinoti, 14 Giovanbattista Venditti, 13 Matteo Pratichetti, 12 Daniel Halangahu, 11 Ruggero Trevisan, 10 Alberto Chiesa, 9 Tito Tebaldi, 8 Andries van Schalkwyk, 7 Mauro Bergamasco, 6 Emiliano Caffini, 5 Josh Sole, 4 Quintin Geldenhuys, 3 Luciano Leibson, 2 Carlo Festuccia, 1 Andrea De Marchi.
Replacements: 16 Andrea Manici, 17 Matias Aguero, 18 Luca Redolfini, 19 Filippo Cazzola, 20 Filippo Ferrarini, 21 Alberto Chillon, 22 Paolo Buso, 23 Alberto Benettin.
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|Friday 20th December|
|19:05||Cardiff Blues vs Ospreys|
|19:05||Ulster vs Zebre|
|19:35||Glasgow vs Benetton Treviso|
|19:35||Edinburgh vs Leinster|
|Saturday 21st December|
|17:00||Connacht vs Newport Gwent D'gons|
|19:15||Munster vs Scarlets|
|Thursday 26th December|
|14:00||Scarlets vs Ospreys|
|15:05||Edinburgh vs Glasgow|
|17:00||Newport Gwent D'gons vs Cardiff Blues|
|Friday 27th December|
|19:15||Munster vs Connacht|
|Saturday 28th December|
|15:00||Benetton Treviso vs Zebre|
|18:45||Leinster vs Ulster|
|Wednesday 1st January|
|14:05||Cardiff Blues vs Newport Gwent D'gons|
|18:05||Glasgow vs Edinburgh|
|Friday 3rd January|
|19:05||Ulster vs Munster|
|Saturday 4th January|
|15:00||Zebre vs Benetton Treviso|
|15:00||Connacht vs Leinster|
|15:00||Ospreys vs Scarlets|
|Saturday 8th February|
|15:00||Benetton Treviso vs Scarlets|
|15:00||Newport Gwent D'gons vs Edinburgh|
|15:00||Glasgow vs Connacht|
|15:00||Zebre vs Leinster|
|15:00||Ulster vs Ospreys|
|15:00||Munster vs Cardiff Blues|
|Saturday 15th February|
|15:00||Connacht vs Edinburgh|
|Saturday 30th November|
|Leinster 36 - 19 Scarlets|
|Benetton Treviso 26 - 26 Cardiff Blues|
|Zebre 11 - 19 Ulster|
|Friday 29th November|
|Edinburgh 43 - 10 Connacht|
|Newport Gwent D'gons 14 - 18 Munster|
|Ospreys 16 - 28 Glasgow|
|Sunday 24th November|
|Benetton Treviso 20 - 21 Leinster|
|Saturday 23rd November|
|Cardiff Blues 10 - 31 Munster|
|Connacht 21 - 24 Scarlets|
|Ospreys 30 - 20 Zebre|
|Friday 22nd November|
|Glasgow 8 - 23 Newport Gwent D'gons|
|Ulster 41 - 17 Edinburgh|
|Saturday 2nd November|
|Munster 12 - 6 Ospreys|
|Scarlets 17 - 9 Ulster|
|Connacht 12 - 19 Glasgow|
|Cardiff Blues 17 - 13 Benetton Treviso|
|Friday 1st November|
|Edinburgh 25 - 23 Zebre|
|Newport Gwent D'gons 19 - 23 Leinster|
|Saturday 26th October|
|Leinster 16 - 13 Connacht|
|Friday 25th October|
|Edinburgh 20 - 13 Benetton Treviso|
|Glasgow 6 - 13 Munster|
|Ulster 39 - 21 Cardiff Blues|
|Ospreys 40 - 17 Newport Gwent D'gons|
|Zebre 16 - 16 Scarlets|
Read the thoughts and opinions of Stuart Barnes with skysports.com