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Zebre will hand a debut to former Waratahs playmaker Daniel Halangahu in Friday's PRO12 clash with Edinburgh at Murrayfield.
Halangahu's first appearance is one of a number of changes made by director of rugby Christian Gajan to the starting XV following the home loss to Connacht last week.
Centre Matteo Pratichetti wins his first ever cap in a Zebre shirt in an all-new midfield, while Alberto Chiesa is handed the fly-half role ahead of Luciano Orquera and Tito Tebaldi features at scrum-half.
On the bench, full-back Paolo Buso and young hooker Andrea Manici are also set for debuts.
Italian international lock Quintin Geldenhuys will be Zebre's skipper for the game in the place of the injured Gonzalo Garcia; veteran second-rower Marco Bortolami is also sidelined.
"This week we worked a lot on the effectiveness of our game: in this is what we're missing,"said Gajan.
"In the first two games we lost too many balls that we had cleverly obtained. For this game we decided to select players who have played less, in order to grow our youngsters"
Meanwhile, Edinburgh have made five changes to the side that started against Cardiff Blues.
Inside centre Matt Scott, who started every match of the Scotland's three-Test June triumph in Australasia, returns for his first match of the new campaign.
The remaining changes come in the pack, with props John Yapp and Willem Nel trading places with Allan Jacobsen and Geoff Cross, who start on the bench.
Scotland's Ross Rennie and Netani Talei of Fiji replace Roddy Grant and the injured David Denton (thigh) in the second row.
Also returning to the squad is Tom Brown, who continues his comeback from a hamstring strain as replacement.
Edinburgh: 15 Greig Tonks, 14 Lee Jones, 13 Nick De Luca, 12 Matt Scott, 11 Tim Visser, 10 Greig Laidlaw (capt), 9 Richie Rees, 8 Netani Talei, 7 Ross Rennie, 6 Stuart McInally, 5 Sean Cox, 4 Grant Gilchrist, 3 Willem Nel, 2 Ross Ford, 1 John Yapp.
Replacements: 16 Andy Titterrell, 17 Allan Jacobsen, 18 Geoff Cross, 19 Perry Parker, 20 Dimitri Basilaia, 21 Chris Leck, 22 John Houston, 23 Tom Brown.
Zebre: 15 Sinoti Sinoti, 14 Giovanbattista Venditti, 13 Matteo Pratichetti, 12 Daniel Halangahu, 11 Ruggero Trevisan, 10 Alberto Chiesa, 9 Tito Tebaldi, 8 Andries van Schalkwyk, 7 Mauro Bergamasco, 6 Emiliano Caffini, 5 Josh Sole, 4 Quintin Geldenhuys, 3 Luciano Leibson, 2 Carlo Festuccia, 1 Andrea De Marchi.
Replacements: 16 Andrea Manici, 17 Matias Aguero, 18 Luca Redolfini, 19 Filippo Cazzola, 20 Filippo Ferrarini, 21 Alberto Chillon, 22 Paolo Buso, 23 Alberto Benettin.
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|Friday 18th April|
|17:00||Leinster vs Benetton Treviso|
|19:35||Glasgow vs Ulster|
|Saturday 19th April|
|14:30||Zebre vs Edinburgh|
|18:15||Connacht vs Munster|
|Sunday 20th April|
|14:00||Cardiff Blues vs Scarlets|
|16:45||Newport Gwent D'gons vs Ospreys|
|Saturday 26th April|
|19:05||Glasgow vs Edinburgh|
|Thursday 1st May|
|17:00||Zebre vs Ospreys|
|Friday 2nd May|
|19:00||Benetton Treviso vs Glasgow|
|19:05||Scarlets vs Newport Gwent D'gons|
|19:30||Ulster vs Leinster|
|Saturday 3rd May|
|17:00||Edinburgh vs Munster|
|17:00||Connacht vs Cardiff Blues|
|Saturday 10th May|
|18:30||Leinster vs Edinburgh|
|18:30||Ospreys vs Connacht|
|18:30||Newport Gwent D'gons vs Benetton Treviso|
|18:30||Munster vs Ulster|
|18:30||Scarlets vs Cardiff Blues|
|18:30||Glasgow vs Zebre|
|Saturday 12th April|
|Munster 5 - 22 Glasgow|
|Scarlets 27 - 20 Zebre|
|Benetton Treviso 45 - 27 Newport Gwent D'gons|
|Friday 11th April|
|Edinburgh 22 - 29 Cardiff Blues|
|Ulster 58 - 12 Connacht|
|Ospreys 25 - 19 Leinster|
|Friday 4th April|
|Glasgow 29 - 10 Benetton Treviso|
|Thursday 3rd April|
|Newport Gwent D'gons 19 - 23 Edinburgh|
|Sunday 30th March|
|Scarlets 32 - 30 Connacht|
|Saturday 29th March|
|Leinster 22 - 18 Munster|
|Cardiff Blues 28 - 23 Ulster|
|Benetton Treviso 20 - 16 Edinburgh|
|Zebre 25 - 25 Newport Gwent D'gons|
|Friday 28th March|
|Glasgow 11 - 9 Ospreys|
|Sunday 23rd March|
|Newport Gwent D'gons 8 - 24 Connacht|
|Saturday 22nd March|
|Munster 14 - 3 Benetton Treviso|
|Glasgow 14 - 6 Scarlets|
|Friday 21st March|
|Edinburgh 3 - 9 Ulster|
|Leinster 27 - 0 Zebre|
|Ospreys 34 - 9 Cardiff Blues|
|Friday 14th March|
|Ulster 26 - 13 Scarlets|
|Saturday 1st March|
|Leinster 28 - 25 Glasgow|
|Scarlets 18 - 13 Munster|
|Connacht 38 - 6 Benetton Treviso|
|Zebre 15 - 10 Cardiff Blues|
Read the thoughts and opinions of Stuart Barnes with skysports.com