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Table-toppers Ulster host Connacht in an inter-pro derby at Ravenhill in what promises to be an emotional occasion.
The clash will mark Ulster's first home game since the passing of centre Nevin Spence, who was killed along with his brother and their father in a farming tragedy.
Mark Anscombe's side will be aiming to make it five RaboDirect PRO12 wins on the bounce this season having made their best-ever start to a campaign.
Anscombe has made four changes to the starting team. Ireland hooker Rory Best has returned to fitness and will play for his province for the first time since the Heineken Cup final in May. Johann Muller (captain), Stephen Ferris and Paddy Wallace are all called into the starting XV.
Prop Declan Fitzpatrick had also been called into the starting XV but has since withdrawn after aggravating a medial ligament injury in training on Thursday morning, with John Afoa starting in his place.
Meanwhile, Connacht head coach Eric Elwood has made four changes to his starting XV following the 34-6 win over Leinster last time.
Up front, Denis Buckley makes way for Brett Wilkinson as loosehead prop while Ronan Loughney, who last week was called up to the Irish training squad, returns at tighthead.
Elsewhere in the pack, Dave Gannon replaces Eoin McKeon as blindside flanker. Gannon is joined in the back-row by former Ulster flanker Willie Faloon, who will captain Connacht.
There are no changes to the backs with Dan Parks making his second appearance for the province as fly-half. Try scorers from last week Tiernan O'Halloran and Fetu'u Vainikolo start again on the wing while the centre partnership is Eoin Griffin and Dave McSharry.
Ulster: 15 Jared Payne, 14 Tommy Bowe, 13 Darren Cave, 12 Paddy Wallace, 11 Andrew Trimble, 10 Paddy Jackson, 9 Paul Marshall, 8 Nick Williams, 7 Chris Henry, 6 Stephen Ferris, 5 Dan Tuohy, 4 Johan Muller (c), 3 John Afoa, 2 Rory Best, 1 Tom Court. Replacements: 16 Rob Herring, 17 Callum Black, 18 Adam Macklin, 19 Lewis Stevenson, 20 Mike McComish, 21 Michael Heaney, 22 Luke Marshall, 23 Craig Gilroy.
Connacht: 15 Robbie Henshaw, 14 Tiernan O'Halloran, 13 Eoin Griffin, 12 Dave McSharry, 11 Fetu'u Vainikolo, 10 Dan Parks, 9 Kieran Marmion, 8 George Naoupu, 7 Willie Faloon (capt), 6 Dave Gannon, 5 Mike McCarthy, 4 Michael Swift, 3 Ronan Loughney, 2 Adrian Flavin, 1 Brett Wilkinson. Replacements: 16 Jason Harris-Wright, 17 Denis Buckley, 18 Nathan White, 19 John Muldoon, 20 Johnny O'Connor, 21 Dave Moore, 22 Miah Nikora, 23 Mata Fifita.
"The first game back at Ravenhill is obviously going to be a fairly emotional match I think for the supporters and for the players and hopefully we'll do Nevin justice."
"We're very proud of the way we played on Friday but the big test now is to ensure we can play like that against Ulster this week and on a regular basis throughout the season."
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|Saturday 25th May|
|16:45||Ulster vs Leinster|
|Saturday 11th May|
|Leinster 17 - 15 Glasgow|
|Friday 10th May|
|Ulster 28 - 17 Scarlets|
|Friday 3rd May|
|Edinburgh 31 - 24 Newport Gwent D'gons|
|Connacht 3 - 20 Glasgow|
|Zebre 25 - 27 Munster|
|Ulster 37 - 13 Cardiff Blues|
|Scarlets 17 - 41 Benetton Treviso|
|Leinster 37 - 19 Ospreys|
|Friday 26th April|
|Benetton Treviso 23 - 23 Connacht|
|Sunday 21st April|
|Zebre 22 - 41 Leinster|
|Saturday 20th April|
|Scarlets 24 - 6 Cardiff Blues|
|Friday 19th April|
|Connacht 18 - 34 Ulster|
|Glasgow 35 - 17 Ospreys|
|Benetton Treviso 30 - 10 Edinburgh|
|Newport Gwent D'gons 30 - 24 Munster|
|Saturday 13th April|
|Ospreys 28 - 3 Benetton Treviso|
|Munster 16 - 22 Leinster|
|Cardiff Blues 28 - 13 Zebre|
|Friday 12th April|
|Edinburgh 24 - 32 Connacht|
|Ulster 31 - 5 Newport Gwent D'gons|
|Scarlets 29 - 6 Glasgow|
|Saturday 30th March|
|Leinster 18 - 22 Ulster|
|Cardiff Blues 16 - 23 Ospreys|
|Newport Gwent D'gons 20 - 28 Scarlets|
Read the thoughts and opinions of Stuart Barnes with skysports.com