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Edinburgh have made six changes to their line-up for Friday's RaboDirect PRO12 clash with defending champions Ospreys.
Crucially the Murrayfield-based side will welcome back British and Irish Lions hooker Ross Ford to their line-up.
Izak van der Westhuizen and Perry Parker also come into the pack, while Sep Visser, Dougie Fife and Richie Rees added to the back division.
Head coach Michael Bradley, though, is without a number of players with Geoff Cross, Nick De Luca, David Denton, Grant Gilchrist, Greig Laidlaw, Matt Scott, Tim Visser all on international duty.
Andrew Bishop will set a new appearance record for the Ospreys when he lines up in the centres.
Bishop, whose debut came against the Borders in 2005, will be making his 181st appearance for the region, moving ahead of Paul James at the top of the list.
At the other end of the spectrum, Owen Williams makes his RaboDirect PRO12 debut - with Nicky Thomas set for his first domestic appearance if he comes off the bench.
Edinburgh: 15 Greig Tonks, 14 Sep Visser, 13 Dougie Fife, 12 James King, 11 Tom Brown, 10 Gregor Hunter, 9 Richie Rees, 1 John Yapp, 2 Ross Ford, 3 Willem Nel, 4 Perry Parker, 5 Izak van der Westhuizen, 6 Sean Cox (capt), 7 Roddy Grant, 8 Stuart McInally.
Replacements: 16 Alun Walker, 17 Allan Jacobsen, 18 Lewis Niven, 19 Robert McAlpine, 20 Hamish Watson, 21 Chris Leck, 22 John Houston, 23 Mike Penn
Ospreys: 15 Richard Fussell, 14 Tom Isaacs, 13 Andrew Bishop, 12 Jonathan Spratt, 11 Eli Walker, 10 Matthew Morgan, 9 Rhys Webb, 1 Ryan Bevington, 2 Scott Baldwin, 3 Owen Williams, 4 Lloyd Peers, 5 James King, 6 George Stowers, 7 Sam Lewis, 8 Joe Bearman (capt).
Replacements: 16 Duncan Jones, 17 Matthew Dwyer, 18 Nicky Thomas, 19 Ian Gough, 20 Morgan Allen, 21 Tom Habberfield, 22 Matthew Morgan, 23 Ross Jones
"We return for the first match in the 'second phase' of the season and look to get moving against a formidable opponent in the shape of the PRO12 champions.
"They come here full of confidence having won five on the bounce in the league and will be keen to maintain their run and underline their championship credentials.
"Both matches last season were close affairs; at Liberty Stadium they cleared their lines and ran the full length to score in the last minute and here, at Murrayfield, they edged us by a single point, thanks to the converted try-of-the-season from [Hanno] Dirksen."
"This is the first of two big PRO12 games over the next couple of weeks that will really test us. Edinburgh away and then Cardiff Blues home are always tough games, and there's no doubt that we are going to have to show plenty of spirit, commitment and desire on and off the pitch if we are going to get what we want from these matches.
"There's a lot of responsibility on some young shoulders during international periods and it's been pleasing to see players stepping up to the mark and really taking their chances.
"What equally important to us is the input of senior guys like Duncan, Bearman, Gough and Fussell. We've kept hold of a group of experienced players who have the right attitude, knowing that we can mould younger players around them."
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|Sunday 20th April|
|14:00||Cardiff Blues vs Scarlets|
|16:45||Newport Gwent D'gons vs Ospreys|
|Saturday 26th April|
|19:05||Glasgow vs Edinburgh|
|Thursday 1st May|
|17:00||Zebre vs Ospreys|
|Friday 2nd May|
|19:00||Benetton Treviso vs Glasgow|
|19:05||Scarlets vs Newport Gwent D'gons|
|19:30||Ulster vs Leinster|
|Saturday 3rd May|
|17:00||Edinburgh vs Munster|
|17:00||Connacht vs Cardiff Blues|
|Saturday 10th May|
|18:30||Leinster vs Edinburgh|
|18:30||Scarlets vs Cardiff Blues|
|18:30||Ospreys vs Connacht|
|18:30||Newport Gwent D'gons vs Benetton Treviso|
|18:30||Munster vs Ulster|
|18:30||Glasgow vs Zebre|
|Saturday 19th April|
|Connacht 23 - 32 Munster|
|Zebre 26 - 13 Edinburgh|
|Friday 18th April|
|Glasgow 27 - 9 Ulster|
|Leinster 62 - 7 Benetton Treviso|
|Saturday 12th April|
|Munster 5 - 22 Glasgow|
|Scarlets 27 - 20 Zebre|
|Benetton Treviso 45 - 27 Newport Gwent D'gons|
|Friday 11th April|
|Edinburgh 22 - 29 Cardiff Blues|
|Ulster 58 - 12 Connacht|
|Ospreys 25 - 19 Leinster|
|Friday 4th April|
|Glasgow 29 - 10 Benetton Treviso|
|Thursday 3rd April|
|Newport Gwent D'gons 19 - 23 Edinburgh|
|Sunday 30th March|
|Scarlets 32 - 30 Connacht|
|Saturday 29th March|
|Leinster 22 - 18 Munster|
|Cardiff Blues 28 - 23 Ulster|
|Benetton Treviso 20 - 16 Edinburgh|
|Zebre 25 - 25 Newport Gwent D'gons|
|Friday 28th March|
|Glasgow 11 - 9 Ospreys|
|Sunday 23rd March|
|Newport Gwent D'gons 8 - 24 Connacht|
|Saturday 22nd March|
|Munster 14 - 3 Benetton Treviso|
|Glasgow 14 - 6 Scarlets|
|Friday 21st March|
|Edinburgh 3 - 9 Ulster|
|Leinster 27 - 0 Zebre|
|Ospreys 34 - 9 Cardiff Blues|
|Friday 14th March|
|Ulster 26 - 13 Scarlets|
Read the thoughts and opinions of Stuart Barnes with skysports.com