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England winger Ugo Monye will return to the Harlequins line-up to face London Welsh at the Stoop on Friday.
Monye missed the opening win over Wasps through injury, but his return means George Lowe can slot back into the centres alongside Jordan Turner-Hall.
Karl Dickson also comes into the backs after impressing off the bench, while Tom Guest is named in the back-row.
Ben Botica is poised for his debut off the bench after he landed 17 points for the A team against Saracens on Monday.
Welsh boss Lyn Jones has made five changes to his starting XV - including a debut for Tyson Keats.
The New Zealand scrum-half starts after joining from the now-defunct Aironi, with Nick Runciman retaining his place on the bench.
Matt Corker, Mike Denbee and Ed Jackson also start, while a positional switch sees Daniel Browne moving from No.8 to blindside flanker.
Harlequins: 15 Mike Brown, 14 Tom Williams, 13 George Lowe, 12 Jordan Turner-Hall, 11 UgoMonye, 10 Nick Evans, 9 Karl Dickson, 8 Tom Guest, 7 Chris Robshaw (c), 6 Maurie Fa'asavalu, 5 George Robson, 4 Olly Kohn, 3 James Johnston, 2 Joe Gray, 1 Joe Marler. Replacements: 16 Rob Buchanan, 17 Darryl Marfo, 18 Kyle Sinckler, 19 Charlie Matthews, 20 Nick Easter, 21 Danny Care, 22 Ben Botica, 23 Matt Hopper.
London Welsh: 15 Tom Arscott, 14 Phil Mackenzie, 13 Sonny Parker, 12 Hudson Tonga'uiha, 11 Joe Ajuwa, 10 Gordon Ross, 9 Tyson Keats, 1 Frank Montanella, 2 Neil Briggs, 3 Paulica Ion, 4 Jonathan Mills (capt), 5 Matt Corker, 6 Daniel Browne, 7 Mike Denbee, 8 Ed Jackson. Replacements: 16 Dan George, 17 Tom Bristow, 18 Arthur Joly, 19 Kirill Kulemin, 20 Alfie To'oala, 21 Nick Runciman, 22 Seb Jewell, 23 Nick Scott.
|Click here for more betting|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Saracens vs Worcester|
|15:00||Exeter vs Harlequins|
|15:00||Gloucester vs London Irish|
|15:00||Sale vs Leicester|
|15:00||Wasps vs Newcastle|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Leicester vs Saracens|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
Read the thoughts and opinions of Stuart Barnes with skysports.com