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Premiership new boys London Welsh will be hoping secure their first win of the season against Exeter at Kassam Stadium.
Welsh have lost their two opening games since winning promotion while Exeter beat Sale before losing to Northampton.
Sunday will be the sides' first meeting since Exeter's 2009/10 promotion season - the inaugural season of the Championship.
A 13-9 defeat at Sandy Park during the regular season was reversed by the Exiles at Old Deer Park, 12-10, thanks to Guy Mercer's last-gasp try and Gordon Ross' conversion.
Welsh coach Lyn Jones makes one change to his starting line-up for Sunday's clash.
Nick Scott, who scored seven tries in twelve Championship appearances for the Exiles last term after joining the club on loan from Bath, comes in for Joe Ajuwa on the wing, with Scott's place on the bench taken by James Lewis.
The only other change sees Jonah Holmes, a try-scorer against Harlequins in the sides' Aviva A League meeting, return to the London Welsh matchday 23 in place of Nick Runciman.
Meanwhile, the Chiefs head into the game having to make one enforced change to their starting line-up as winger Josh Tatupu has been ruled out through injury.
The Samoan international broke his ankle early in the second half of the game at Franklin's Gardens, so Fijian star Sireli Naqelevuki is promoted from the bench to start in the centre with Irishman Ian Whitten shifting to the wing.
The other change in personnel to the starting XV sees James Hanks come back into the second-row at the expense of Aly Muldowney, who fills the void left by Hanks on the bench. Jack Nowell and Carl Rimmer will make their first-ever Premiership appearances if summoned.
Exeter coach Rob Baxter is keen to reward those who shine, both on the field and in training, and although the Chiefs suffered their first setback of the campaign last weekend, the head coach saw enough encouraging signs from his troops in the heat of battle to stick with a tried-and-trusted formula.
"We've said from the very outset this season that we look to hit every game flat out and take whatever comes from it," said Baxter.
"Looking back at the game, we got a couple of things tactically wrong on the day that hurt us, particularly in the first and last quarter, but for a second game of the season it was a great game to work on and improve the side.
"Sometimes you need those types of game - I know it sounds strange - but say we had scored a try in that last passage of play to win the game, probably a few things would have got papered over that were genuine issues for us. In the end we came up a bit short, but we've dealt with those issues this week and now we will look to improve again."
London Welsh: 15 Tom Arscott, 14 Phil Mackenzie, 13 Sonny Parker, 12 Hudson Tonga'uiha, 11 Nick Scott, 10 Gordon Ross, 9 Tyson Keats, 8 Ed Jackson, 7 Mike Denbee, 6 Daniel Browne, 5 Matt Corker, 4 Jonathan Mills (capt), 3 Paulica Ion, 2 Neil Briggs, 1 Frank Montanella.
Replacements: 16 Dan George, 17 Tom Bristow, 18 Arthur Joly, 19 Kirill Kulemin, 20 Alfie To'oala, 21 Jonah Holmes, 22 James Lewis, 23 Seb Jewell.
Exeter: 15 Luke Arscott, 14 Ian Whitten, 13 Sireli Naqelevuki, 12 Phil Dollman, 11 Matt Jess, 10 Ignacio Mieres, 9 Will Chudley, 8 Richard Baxter, 7 James Scaysbrook, 6 Tom Johnson, 5 James Hanks, 4 Tom Hayes (capt), 3 Craig Mitchell, 2 Chris Whitehead, 1 Brett Sturgess.
Replacements: 16 Simon Alcott, 17 Ben Moon, 18 Carl Rimmer, 19 Aly Muldowney, 20 James Phillips, 21 Kevin Barrett, 22 Gareth Steenson, 23 Jack Nowell.
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|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Saracens vs Worcester|
|15:00||Exeter vs Harlequins|
|15:00||Gloucester vs London Irish|
|15:00||Sale vs Leicester|
|15:00||Wasps vs Newcastle|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Leicester vs Saracens|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
Read the thoughts and opinions of Stuart Barnes with skysports.com