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Northampton show two changes from the side that defeated Worcester five days ago for the Aviva Premiership clash with Wasps on Friday.
Centre Dom Waldouck replaces George Pisi alongside Luther Burrell in midfield and England flanker Tom Wood features at openside instead of Phil Dowson, who is on bench duty.
Saints are one of only two unbeaten teams in the Aviva Premiership but their director of rugby Jim Mallinder expects a tough test from Wasps.
"They have been very competitive in every game and shown their willingness to play as a team for the full 80 minutes. They soundly beat London Irish two weeks ago and put over 40 points past Harlequins in Round 1 as well," he said.
Prop Tim Payne will make his 250th appearance for Wasps as the Londoners look to bounce back from last weekend's defeat at Gloucester.
Winger James Bailey makes a first-team debut, replacing Tom Varndell, while there are also starts for fly-half Nicky Robinson, flanker Joe Launchbury and No 8 Billy Vunipola.
Stephen Jones has not recovered from stomach illness and his place on the bench has been taken by Lee Thomas.
Northampton: Wilson, K Pisi, Waldouck, Burrell, Artemyev, Myler, Dickson; Tonga'uiha, Hartley (capt), Doran Jones, Manoa, Day, Lawes, Wood, Oakley. Replacements: Haywood, Mujati, Waller, Sorenson, Dowson, Roberts, Lamb, May.
Wasps: T Bell, Wade, Masi, C Bell, Bailey, Robinson, Simpson; Payne, Lindsay, Taufalo, Palmer, Wentzel (capt), Launchbury, Haskell, Vunipola. Replacements: Rhys Thomas, McIntyre, Staibano, Sam Jones, Cannon, Davies, Lee Thomas, Daly.
|Click here for more betting|
|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com