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New Sale director of rugby John Mitchell has made three changes for his first match in charge against Northampton at Salford City Stadium on Friday.
The former New Zealand coach took over first-team affairs earlier in the week and will be looking to lead his new side to their second Aviva Premiership victory of the season when they host the Saints.
Cameron Shepherd comes back in at full-back, while centre Johnny Leota and lock Richie Gray are included in the starting XVafter returning from international duty for Samoa and Scotland respectively.
A position change is also made in the back row, with Andy Powell switching from No. 8 to flanker and Richie Vernon making the opposite move.
Northampton have been given a boost with the return of England internationals Ben Foden and Dylan Hartley to their line-up for the contest.
Foden will play for the first time since September after recovering from an ankle injury while skipper Hartley is back in the fold following a knee problem.
There is further good news for Northampton boss and former Sale player and coach Jim Mallinder as centre George Pisi also returns after returning from international duty with Samoa.
Lee Dickson returns to the bench but Northampton have lost lock Courtney Lawes after his England call-up, meaning Mark Sorenson come back into the second row.
Sale: 15 Cameron Shepherd, 14 Charlie Amesbury, 13 Johnny Leota, 12 Sam Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Dwayne Peel, 8 Richie Vernon 7 David Seymour (c), 6 Andy Powell, 5 Kearnan Myall, 4 Richie Gray, 3 Tony Buckley, 2 Tommy Taylor, 1 Ross Harrison.
Replacements: 16 Joe Ward, 17 Eifion Lewis-Roberts, 18 Vadim Cobilas, 19 Fraser McKenzie, 20 James Gaskell, 21 Will Cliff, 22 Nick Macleod, 23 Rob Miller.
Northampton: 15 Ben Foden, 14 Ken Pisi, 13, George Pisi 12 Dom Waldouck, 11 Jamie Elliott, 10 Ryan Lamb, 9 Martin Roberts, 8 GJ Van Velze, 7 Phil Dowson, 6 Calum Clark 5 Mark Sorenson, 4 Samu Manoa, 3 Brian Mujati, 2 Dylan Hartley (c), 1 Soane Tonga'uiha.
Replacements: 16 Mike Haywood, 17 Alex Waller, 18 Paul Doran Jones, 19 Rhys Oakley, 20, Ben Nutley 21 Lee Dickson, 22 Stephen Myler, 23 Tom May.
"Sale have been getting some disappointing results this season and we're expecting them to be very motivated for tomorrow's game, especially with the return of John Mitchell to the club.
"They have talented players who will no doubt be looking to prove a point, and after having won their last three home matches in all competitions they have developed a winning habit in Salford over the past month.
"We know we will have a big job on our hands, but all our focus this week has been on getting a good result on Friday night. This season the Aviva Premiership is more competitive than ever and every point matters.
"We have had two wins in the past two weeks and now we want to build on that tomorrow."
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|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com