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Saracens have made four changes to their starting XV for the Aviva Premiership clash with Northampton at stadiummk on Sunday.
Ernst Joubert comes in at No 8 to skipper the side as club captain Steve Borthwick is rested and his place in the second row taken by George Kruis, who switches from flanker.
Schalk Brits drops to the bench after the win against Bath last time out, with his place at hooker taken by fellow South African star John Smit.
Richard Wigglesworth and Owen Farrell also have to settle for spots on the bench as their respective places at scrum-half and inside centre are taken by Neil de Kock and Brad Barritt.
Andy Saull, Alex Goode, Jackson Wray, Alistair Hargreaves, Joe Maddock, Adam Powell, Jacques Burger and Justin Melck all miss the match through injury
Northampton also make four changes to their line-up following their 18-9 defeat to league leaders Harlequins, although three of those are made in the process of overhauling the front row.
Captain Dylan Hartley comes back in at hooker after serving a suspension and is joined by props Brian Mujati and Alex Waller. The remaining change sees Tom May replaced by Dom Waldouck at inside centre.
Sarries currently lie one point behind Quins at the Aviva Premiership summit while Northampton are two points outside the top four.
Saracens: 15 Chris Wyles, 14 Chris Ashton, 13 Joel Tomkins, 12 Brad Barritt, 11 David Strettle, 10 Charlie Hodgson, 9 Neil de Kock, 8 Ernst Joubert (c), 7 Will Fraser, 6 Kelly Brown, 5 Mouritz Botha, 4 George Kruis, 3 Matt Stevens, 2 John Smit, 1 Mako Vunipola.
Replacements: 16 Schalk Brits, 17 Rhys Gill, 18 Carlos Nieto, 19 Eoin Sheriff, 20 Jono Ross, 21 Richard Wigglesworth, 22 Owen Farrell, 23 James Short.
Northampton: 15 Ben Foden, 14 Ken Pisi, 13 George Pisi, 12 Dom Waldouck, 11 Jamie Elliott, 10 Stephen Myler, 9 Lee Dickson, 8 GJ Van Velze, 7 Phil Dowson, 6 Tom Wood, 5 Courtney Lawes, 4 Samu Manoa, 3 Brian Mujati, 2 Dylan Hartley (c), 1 Alex Waller.
Replacements: 16 Mike Haywood, 17 Soane Tonga'uiha, 18 Paul Doran Jones, 19 Mark Sorenson, 20 Calum Clark, 21 Martin Roberts, 22 Ryan Lamb, 23 Tom May.
"Things didn't go quite our way against Harlequins so everyone has been focused and determined in training this week.
"We certainly have a point to prove against Saracens, and we have the belief in the players' ability and desire to get a result in Milton Keynes.
"Saracens are one of the top teams in Europe, but we know that when we play at our best we are a match for anyone. So nothing less than a top performance will do as we look to end 2012 in a positive way."
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|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com