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Saracens have made four changes to their starting XV for the Aviva Premiership clash with Northampton at stadiummk on Sunday.
Ernst Joubert comes in at No 8 to skipper the side as club captain Steve Borthwick is rested and his place in the second row taken by George Kruis, who switches from flanker.
Schalk Brits drops to the bench after the win against Bath last time out, with his place at hooker taken by fellow South African star John Smit.
Richard Wigglesworth and Owen Farrell also have to settle for spots on the bench as their respective places at scrum-half and inside centre are taken by Neil de Kock and Brad Barritt.
Andy Saull, Alex Goode, Jackson Wray, Alistair Hargreaves, Joe Maddock, Adam Powell, Jacques Burger and Justin Melck all miss the match through injury
Northampton also make four changes to their line-up following their 18-9 defeat to league leaders Harlequins, although three of those are made in the process of overhauling the front row.
Captain Dylan Hartley comes back in at hooker after serving a suspension and is joined by props Brian Mujati and Alex Waller. The remaining change sees Tom May replaced by Dom Waldouck at inside centre.
Sarries currently lie one point behind Quins at the Aviva Premiership summit while Northampton are two points outside the top four.
Saracens: 15 Chris Wyles, 14 Chris Ashton, 13 Joel Tomkins, 12 Brad Barritt, 11 David Strettle, 10 Charlie Hodgson, 9 Neil de Kock, 8 Ernst Joubert (c), 7 Will Fraser, 6 Kelly Brown, 5 Mouritz Botha, 4 George Kruis, 3 Matt Stevens, 2 John Smit, 1 Mako Vunipola.
Replacements: 16 Schalk Brits, 17 Rhys Gill, 18 Carlos Nieto, 19 Eoin Sheriff, 20 Jono Ross, 21 Richard Wigglesworth, 22 Owen Farrell, 23 James Short.
Northampton: 15 Ben Foden, 14 Ken Pisi, 13 George Pisi, 12 Dom Waldouck, 11 Jamie Elliott, 10 Stephen Myler, 9 Lee Dickson, 8 GJ Van Velze, 7 Phil Dowson, 6 Tom Wood, 5 Courtney Lawes, 4 Samu Manoa, 3 Brian Mujati, 2 Dylan Hartley (c), 1 Alex Waller.
Replacements: 16 Mike Haywood, 17 Soane Tonga'uiha, 18 Paul Doran Jones, 19 Mark Sorenson, 20 Calum Clark, 21 Martin Roberts, 22 Ryan Lamb, 23 Tom May.
"Things didn't go quite our way against Harlequins so everyone has been focused and determined in training this week.
"We certainly have a point to prove against Saracens, and we have the belief in the players' ability and desire to get a result in Milton Keynes.
"Saracens are one of the top teams in Europe, but we know that when we play at our best we are a match for anyone. So nothing less than a top performance will do as we look to end 2012 in a positive way."
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|Friday 20th December|
|20:00||Sale Sharks vs London Irish|
|Saturday 21st December|
|15:00||Exeter vs Newcastle|
|15:00||Bath vs Harlequins|
|15:00||Wasps vs Northampton|
|15:00||Saracens vs Leicester|
|Friday 27th December|
|TBC||Newcastle vs Wasps|
|Saturday 28th December|
|15:00||Northampton vs Bath|
|15:00||Worcester vs Saracens|
|15:00||Harlequins vs Exeter|
|15:00||Leicester vs Sale Sharks|
|Friday 3rd January|
|19:45||Newcastle vs Sale Sharks|
|Saturday 4th January|
|15:00||London Irish vs Worcester|
|15:00||Gloucester vs Saracens|
|15:00||Leicester vs Bath|
|Sunday 5th January|
|15:00||Wasps vs Exeter|
|Friday 7th February|
|19:45||Worcester vs Leicester|
|20:00||Sale Sharks vs Gloucester|
|Saturday 8th February|
|15:00||Harlequins vs Wasps|
|15:00||Bath vs Newcastle|
|15:00||Exeter vs Northampton|
|Sunday 9th February|
|15:00||Saracens vs London Irish|
|Friday 14th February|
|20:00||Sale Sharks vs Saracens|
|Saturday 15th February|
|15:00||Wasps vs London Irish|
|15:00||Northampton vs Worcester|
|15:00||Leicester vs Gloucester|
|Sunday 1st December|
|Newcastle 9 - 35 Harlequins|
|Saturday 30th November|
|Bath 21 - 16 Exeter|
|Worcester 10 - 33 Northampton|
|London Irish 12 - 19 Wasps|
|Saracens 24 - 19 Sale Sharks|
|Friday 29th November|
|Gloucester 17 - 22 Leicester|
|Sunday 24th November|
|Wasps 5 - 28 Bath|
|Saturday 23rd November|
|Northampton 18 - 0 Newcastle|
|Harlequins 27 - 19 Gloucester|
|Exeter 9 - 16 Saracens|
|Leicester 20 - 11 London Irish|
|Friday 22nd November|
|Sale Sharks 26 - 10 Worcester|
|Sunday 3rd November|
|Saracens 40 - 3 Newcastle|
|London Irish 14 - 19 Northampton|
|Saturday 2nd November|
|Leicester 16 - 23 Harlequins|
|Gloucester 30 - 32 Wasps|
|Friday 1st November|
|Sale Sharks 16 - 18 Exeter|
|Worcester 6 - 21 Bath|
|Sunday 27th October|
|Newcastle 13 - 11 London Irish|
|Wasps 22 - 12 Leicester|
|Saturday 26th October|
|Northampton 41 - 20 Saracens|
|Exeter 40 - 6 Worcester|
|Harlequins 24 - 3 Sale Sharks|
|Friday 25th October|
|Bath 15 - 13 Gloucester|
Read the thoughts and opinions of Stuart Barnes with skysports.com