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Saracens enter their top-of-the-table clash with Harlequins on the back of three successive Aviva Premiership victories.
Defending champions Quins travel to the Allianz Park on Sunday looking to wipe out the four-point lead Saracens hold at the head of the table.
The hosts have scored twelve tries in their last three outings which have seen them leapfrog Harlequins, who lost to Exeter Chiefs in their last league encounter.
Harlequins do however enter the clash with momentum after lifting the LV Cup last weekend with victory against Sale Sharks, despite their England contingent being unavailable.
The timing of the clash sees both sides ring the changes as a number of key players return from international duty following the culmination of the Six Nations last weekend.
Saracens welcome back Alex Goode, Chris Ashton, Brad Barritt, Owen Farrell and Mako Vunipola from England duty, while Scotland captain Kelly Brown is also named in the starting line-up.
Farrell will start at fly-half which demotes Charlie Hodgson to the bench alongside John Smit, Neil de Kock and Chris Wyles.
Mike Brown, Danny Care, Joe Marler and captain Chris Robshaw all return to the Harlequins starting XV to face the league leaders.
Ugo Monye and Sam Smith begin on the wings for Harlequins with Matt Hopper and Jordan Turner-Hall partnered in the centres.
Joe Gray comes into the side at hooker as Charlie Matthews gets the nod in the second row alongside George Robson.
John Kingston's bench consists of eight players who all featured in the LV Cup final winning side last weekend.
Saracens: 15 Alex Goode, 14 Chris Ashton, 13 Joel Tomkins, 12 Brad Barritt, 11 David Strettle, 10 Owen Farrell, 9 Richard Wigglesworth, 8 Ernst Joubert, 7 Will Fraser, 6 Kelly Brown, 5 Alistair Hargreaves, 4 Steve Borthwick (capt), 3 Matt Stevens, 2 Schalk Brits, 1 Mako Vunipola
Replacements: 16 John Smit, 17 Rhys Gill, 18 Petrus du Plessis, 19 George Kruis, 20 Jackson Wray, 21 Neil de Kock, 22 Charlie Hodgson, 23 Chris Wyles
Harlequins: 15 Mike Brown, 14 Ugo Monye, 13 Matt Hopper, 12 Jordan Turner-Hall, 11 Sam Smith, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw (capt), 6 Tom Guest, 5 George Robson, 4 Charlie Matthews, 3 James Johnston, 2 Joe Gray, 1 Joe Marler
Replacements: 16 Rob Buchanan, 17 Mark Lambert, 18 Will Collier, 19 Maurie Fa'asavalu, 20 Luke Wallace, 21 Karl Dickson, 22 Ben Botica, 23 George Lowe
|Click here for more betting|
|Friday 21st March|
|19:45||Worcester vs Wasps|
|Saturday 22nd March|
|14:00||Sale vs Northampton|
|15:00||Gloucester vs Newcastle|
|15:15||Saracens vs Harlequins|
|17:30||London Irish vs Bath|
|Sunday 23rd March|
|14:00||Leicester vs Exeter|
|Friday 28th March|
|19:45||Bath vs Sale|
|Saturday 29th March|
|15:00||Wasps vs Saracens|
|15:00||Harlequins vs London Irish|
|15:00||Exeter vs Gloucester|
|15:15||Northampton vs Leicester|
|Sunday 30th March|
|14:00||Newcastle vs Worcester|
|Friday 11th April|
|19:45||Sale vs Harlequins|
|Saturday 12th April|
|15:00||Worcester vs Exeter|
|15:00||Leicester vs Wasps|
|15:15||Gloucester vs Bath|
|Sunday 13th April|
|14:00||Saracens vs Northampton|
|15:00||London Irish vs Newcastle|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale Sharks|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
|Sunday 23rd February|
|Saracens 23 - 10 Exeter|
|Newcastle 16 - 22 Northampton|
|London Irish 15 - 20 Leicester|
|Saturday 22nd February|
|Worcester 12 - 24 Sale Sharks|
|Bath 32 - 25 Wasps|
|Gloucester 25 - 20 Harlequins|
|Sunday 16th February|
|Leicester 11 - 8 Gloucester|
|Saturday 15th February|
|Exeter 23 - 27 Bath|
|Wasps 20 - 23 London Irish|
|Northampton 30 - 14 Worcester|
|Harlequins 18 - 14 Newcastle|
|Friday 14th February|
|Sale Sharks 10 - 15 Saracens|
|Sunday 9th February|
|Harlequins 11 - 10 Wasps|
|Saturday 8th February|
|Exeter 16 - 17 Northampton|
|Saracens 13 - 22 London Irish|
|Bath 24 - 6 Newcastle|
|Friday 7th February|
|Sale Sharks 24 - 19 Gloucester|
|Worcester 22 - 23 Leicester|
Read the thoughts and opinions of Stuart Barnes with skysports.com