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Sale will look to make a giant leap towards safety when they take on Gloucester in Friday's Aviva Premiership encounter.
The Sharks have opened up an eight-point gap between themselves and bottom club London Welsh - that means victory over Gloucester will leave the Exiles needing a minor miracle from their remaining three games.
Sharks boss Steve Diamond has made just the one change to his line-up following the 33-33 draw against London Irish - with Will Addison replacing Charlie Amesbury on the wing.
Gloucester welcome back England No 8 Ben Morgan for their trip to Salford City Stadium.
Morgan has recovered from an ankle injury to take a place among the replacements following the Amlin Challenge Cup loss to Biarritz.
Gloucester director of rugby Nigel Davies has made five changes to his starting XV for the clash.
Australia hooker Huia Edmonds comes into the pack, while in the backs Dan Robson, Shane Monahan, Billy Twelvetrees and Rob Cook all return.
Sale Sharks: 15 Cameron Shepherd, 14 Will Addison, 13 Johnny Leota, 12 Sammy Tuitupou, 11 Mark Cueto, 10 Nick Macleod, 9 Dwayne Peel, 8 James Gaskell, 7 David Seymour (c), 6 Daniel Braid, 5 Andrei Ostrikov, 4 Kearnan Myall, 3 Henry Thomas, 2 Marc Jones, 1 Al Dickinson.
Replacements: 16 Tommy Taylor, 17 Ross Harrison, 18 Tony Buckley, 19 Tom Holmes, 20 Andy Powell, 21 Nathan Fowles, 22 Danny Cipriani, 23 Tom Brady.
Gloucester: 15 Rob Cook, 14 Jonny May, 13 Mike Tindall (c), 12 Billy Twelvetrees, 11 Shane Monahan, 10 Freddie Burns, 9 Dan Robson, 8 Sione Kalamafoni, 7 Akapusi Qera, 6 Tom Savage, 5 Will James, 4 Lua Lokotui, 3 Dario Chistolini, 2 Huia Edmonds, 1 Nick Wood.
Replacements: 16 Koree Britton, 17 Dan Murphy, 18 Yann Thomas, 19 Ben Morgan, 20 Andy Hazell, 21 Dave Lewis, 22 Henry Trinder, 23 Charlie Sharples.
|Click here for more betting|
|Friday 18th April|
|19:45||Harlequins vs Leicester|
|Saturday 19th April|
|15:00||Bath vs Worcester|
|15:00||Exeter vs Sale|
|15:15||Wasps vs Gloucester|
|Sunday 20th April|
|14:00||Northampton vs London Irish|
|15:00||Newcastle vs Saracens|
|Saturday 3rd May|
|15:00||Bath vs Northampton|
|15:00||Saracens vs Worcester|
|15:00||Exeter vs Harlequins|
|15:00||Gloucester vs London Irish|
|15:00||Sale vs Leicester|
|15:00||Wasps vs Newcastle|
|Saturday 10th May|
|15:15||Newcastle vs Exeter|
|15:15||Leicester vs Saracens|
|15:15||Northampton vs Wasps|
|15:15||Worcester vs Gloucester|
|15:15||Harlequins vs Bath|
|15:15||London Irish vs Sale|
|Sunday 13th April|
|London Irish 40 - 12 Newcastle|
|Saracens 28 - 24 Northampton|
|Saturday 12th April|
|Gloucester 17 - 18 Bath|
|Worcester 33 - 38 Exeter|
|Leicester 27 - 15 Wasps|
|Friday 11th April|
|Sale Sharks 12 - 27 Harlequins|
|Sunday 30th March|
|Newcastle 12 - 17 Worcester|
|Saturday 29th March|
|Northampton 16 - 22 Leicester|
|Wasps 20 - 32 Saracens|
|Exeter 13 - 14 Gloucester|
|Harlequins 23 - 9 London Irish|
|Friday 28th March|
|Bath 11 - 12 Sale Sharks|
|Sunday 23rd March|
|Leicester 45 - 15 Exeter|
|Saturday 22nd March|
|London Irish 23 - 44 Bath|
|Saracens 39 - 17 Harlequins|
|Gloucester 40 - 33 Newcastle|
|Sale Sharks 19 - 6 Northampton|
|Friday 21st March|
|Worcester 11 - 13 Wasps|
|Sunday 2nd March|
|Newcastle 18 - 41 Leicester|
|Saturday 1st March|
|Northampton 39 - 13 Gloucester|
|Exeter 18 - 0 London Irish|
|Harlequins 21 - 20 Worcester|
|Wasps 17 - 21 Sale Sharks|
|Friday 28th February|
|Bath 10 - 23 Saracens|
Read the thoughts and opinions of Stuart Barnes with skysports.com